Function of miR-451 in angiogenesis, hematopoiesis and cardiogenesis

miR-451在血管生成、造血和心脏发生中的功能

基本信息

  • 批准号:
    8320278
  • 负责人:
  • 金额:
    $ 5.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-15 至 2013-09-14
  • 项目状态:
    已结题

项目摘要

MicroRNAs (miRs) are small non-coding RNAs that post-transcriptionally repress gene expression and play important roles in a wide range of biological processes, including cell fate determination and organogenesis during embryonic development. Several miRs that function in cardiovascular development have been studied revealing their importance in the delicate regulation of this developmental process. More miRs involved in this process are being studied and the overall results will broaden our understanding of the formation of cardiovascular system and eventually benefit the diagnosis, prevention and therapy of human cardiovascular diseases. Our long-term objective is to identify these miRs and elucidate the underlying mechanism of how these miRs regulate cardiovascular development. Our preliminary studies have demonstrated that miR-451, a highly conserved miR identified from a screen for cardiogenic miRs, is expressed extensively in endothelial and blood cell lineages during embryogenesis and has distinct functions during in vitro embryonic stem cell differentiation by promoting the differentiation of endothelial and blood cells while blocking the differentiation of cardiomyocytes. This function is achieved at least partially through the downregulation of target Acvr2a and upregulation of Wnt signaling. However, the in vivo function of miR-451 in cardiovascular development has not been investigated. Therefore, the hypothesis of this project is that miR-451 functions in angiogenesis, hematopoiesis and cardiogenesis during embryogenesis by regulating the specification of respective cell lineages. To test this hypothesis, three specific aims are proposed: 1. To identify the cardiovascular phenotype of miR-451 knockout mice. 2. To investigate the role of miR-451 in the specification of endothelial, blood and cardiac cell lineages during development. 3. To elucidate molecular mechanism underlying miR-451's function in cardiovascular developmental. The proposed studies should not only gain insights into the mechanisms of miR-451 functions in cardiovascular development, but also provide valuable information on the cell lineage determination regulated by miRs during early development.
MicroRNAs (miRs)是一种小的非编码rna,在转录后抑制基因表达,并在广泛的生物学过程中发挥重要作用,包括胚胎发育过程中细胞命运的决定和器官发生。一些在心血管发育中起作用的miRs已经被研究,揭示了它们在这一发育过程的微妙调节中的重要性。更多参与这一过程的miRs正在研究中,总体结果将拓宽我们对心血管系统形成的理解,最终有利于人类心血管疾病的诊断、预防和治疗。我们的长期目标是鉴定这些miRs并阐明这些miRs如何调节心血管发展的潜在机制。

项目成果

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Ye Tao其他文献

Ye Tao的其他文献

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{{ truncateString('Ye Tao', 18)}}的其他基金

Function of miR-451 in angiogenesis, hematopoiesis and cardiogenesis
miR-451在血管生成、造血和心脏发生中的功能
  • 批准号:
    8265197
  • 财政年份:
    2010
  • 资助金额:
    $ 5.77万
  • 项目类别:
Function of miR-451 in angiogenesis, hematopoiesis and cardiogenesis
miR-451在血管生成、造血和心脏发生中的功能
  • 批准号:
    8151049
  • 财政年份:
    2010
  • 资助金额:
    $ 5.77万
  • 项目类别:
Function of miR-451 in angiogenesis, hematopoiesis and cardiogenesis
miR-451在血管生成、造血和心脏发生中的功能
  • 批准号:
    8002713
  • 财政年份:
    2010
  • 资助金额:
    $ 5.77万
  • 项目类别:

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