Mapping the genes for IBD by admixture linkage disequilibrium in Puerto Ricans

通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱

• 批准号: 8146125
• 负责人: Dermot Patrick McGovern
• 金额: $ 38.43万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146125
• 关键词: 13q; Admixture; African; African American; Algorithms; Antibodies; Area; Behavior; Bioinformatics; Biological Markers; Candidate Disease Gene; Caucasians; Caucasoid Race; Characteristics; Childhood; Chromosome Mapping; Classification; Classification Scheme; Clinical; Clinical Data; Clinical Management; Collection; Communication; Complex; Crohn' s disease; DNA; Data; Data Collection; Development; Disease; Disease Association; Environment; Environmental Risk Factor; European; Exposure to; Future; Genes; Genetic; Genetic Markers; Genetic Research; Genetic Variation; Genetic screening method; Genome; Genotype; Haplotypes; Heterogeneity; Human Genome; Hygiene; Infection; Infectious Agent; Inflammation; Inflammatory Bowel Diseases; Joints; Lead; Linkage Disequilibrium; Location; Maps; Measurement; Measures; Medical center; Methods; Microbe; Modeling; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Native Americans; Onset of illness; Pathogenesis; Patients; Phenotype; Pilot Projects; Population; Predisposition; Puerto Rican; Puerto Rico; Quality Control; Questionnaires; Recruitment Activity; Research Design; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Serum; Severities; Severity of illness; Statistical Models; Susceptibility Gene; Symptoms; Testing; Time; Ulcerative Colitis; Universities; Variant; base; clinical Diagnosis; clinical phenotype; clinically relevant; cohort; disorder subtype; follow-up; genetic analysis; genetic variant; genome wide association study; lymphoblastoid cell line; microorganism antigen; non-genetic; programs; response; trait

DESCRIPTION (provided by applicant): This proposal is submitted in response to the RFA DK-06-504 for continuing our role as a Genetic Research Center (GRC) of the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). Cedars-Sinai Medical Center will collaborate with the University of Puerto Rico for this project; UPR will be responsible for recruiting IBD patients, and CSMC will be responsible for performing genetic tests (genotyping) and analyzing the results, looking for regions of the human genome that contain genes that increase the risk for IBD. The Puerto Rican population is particularly suited for this type of study; the population is a composite of Native-American, African, and Caucasian-European peoples that have mixed together genetically since the time of Columbus. This type of genetic analysis is termed "Mapping by Admixture Linkage Disequilibrium."

描述（由申请人提供）：本提案是为了回应RFA DK-06-504，以继续发挥我们作为NIDDK炎症性肠病遗传学联盟（IBDGC）遗传研究中心（GRC）的作用。Cedars-Sinai医学中心将与波多黎各大学合作开展该项目; UPR将负责招募IBD患者，CSMC将负责进行基因检测（基因分型）并分析结果，寻找人类基因组中含有增加IBD风险的基因的区域。波多黎各人口特别适合这种类型的研究;人口是一个混合的美洲原住民，非洲人和高加索-欧洲人的人，混合在一起的遗传自哥伦布的时间。这种类型的遗传分析被称为“混合连锁不平衡作图”。"