Mapping the genes for IBD by admixture linkage disequilibrium in Puerto Ricans

通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱

• 批准号: 8146125
• 负责人: Dermot Patrick McGovern
• 金额: $ 38.43万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146125
• 关键词: 13q; Admixture; African; African American; Algorithms; Antibodies; Area; Behavior; Bioinformatics; Biological Markers; Candidate Disease Gene; Caucasians; Caucasoid Race; Characteristics; Childhood; Chromosome Mapping; Classification; Classification Scheme; Clinical; Clinical Data; Clinical Management; Collection; Communication; Complex; Crohn' s disease; DNA; Data; Data Collection; Development; Disease; Disease Association; Environment; Environmental Risk Factor; European; Exposure to; Future; Genes; Genetic; Genetic Markers; Genetic Research; Genetic Variation; Genetic screening method; Genome; Genotype; Haplotypes; Heterogeneity; Human Genome; Hygiene; Infection; Infectious Agent; Inflammation; Inflammatory Bowel Diseases; Joints; Lead; Linkage Disequilibrium; Location; Maps; Measurement; Measures; Medical center; Methods; Microbe; Modeling; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Native Americans; Onset of illness; Pathogenesis; Patients; Phenotype; Pilot Projects; Population; Predisposition; Puerto Rican; Puerto Rico; Quality Control; Questionnaires; Recruitment Activity; Research Design; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Serum; Severities; Severity of illness; Statistical Models; Susceptibility Gene; Symptoms; Testing; Time; Ulcerative Colitis; Universities; Variant; base; clinical Diagnosis; clinical phenotype; clinically relevant; cohort; disorder subtype; follow-up; genetic analysis; genetic variant; genome wide association study; lymphoblastoid cell line; microorganism antigen; non-genetic; programs; response; trait

DESCRIPTION (provided by applicant): This proposal is submitted in response to the RFA DK-06-504 for continuing our role as a Genetic Research Center (GRC) of the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). Cedars-Sinai Medical Center will collaborate with the University of Puerto Rico for this project; UPR will be responsible for recruiting IBD patients, and CSMC will be responsible for performing genetic tests (genotyping) and analyzing the results, looking for regions of the human genome that contain genes that increase the risk for IBD. The Puerto Rican population is particularly suited for this type of study; the population is a composite of Native-American, African, and Caucasian-European peoples that have mixed together genetically since the time of Columbus. This type of genetic analysis is termed "Mapping by Admixture Linkage Disequilibrium."

描述（由申请人提供）：该提案是针对RFA DK-06-504提交的，以继续我们作为NIDDK炎症性肠病遗传学联盟（IBDGC）的遗传研究中心（GRC）的作用。 Cedars-Sinai医疗中心将与波多黎各大学合作为该项目合作； UPR将负责招募IBD患者，CSMC将负责进行基因检测（基因分型）并分析结果，寻找人类基因组的区域，这些区域包含增加IBD风险的基因。波多黎各人的人口特别适合这类研究。人口是自哥伦布时代以来遗传上混合在一起的裔美国人，非洲和高加索欧洲人民的综合。这种类型的遗传分析称为“通过混合连接不平衡的映射”。