通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱-猫眼课题宝

通过混合连锁不平衡绘制波多黎各人 IBD 基因图谱

批准号：

8330559

负责人：

Dermot Patrick McGovern

金额：

$26.93万

依托单位：

CEDARS-SINAI MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-09-30 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/8330559

关键词：

13q Admixture African African American Algorithms Antibodies Area Behavior Bioinformatics Biological Markers Candidate Disease Gene Caucasians Caucasoid Race Characteristics Childhood Chromosome Mapping Classification Classification Scheme Clinical Clinical Data Clinical Management Collection Communication Complex Crohn&apos s disease DNA Data Data Collection Development Disease Disease Association Environment Environmental Risk Factor European Exposure to Future Genes Genetic Genetic Markers Genetic Research Genetic Variation Genetic screening method Genome Genotype Haplotypes Heterogeneity Human Genome Hygiene Infection Infectious Agent Inflammation Inflammatory Bowel Diseases Joints Lead Linkage Disequilibrium Location Maps Measurement Measures Medical center Methods Microbe Modeling Molecular National Institute of Diabetes and Digestive and Kidney Diseases Native Americans Onset of illness Pathogenesis Patients Phenotype Pilot Projects Population Predisposition Puerto Rican Puerto Rico Quality Control Questionnaires Recruitment Activity Research Design Research Personnel Resources Risk Role Sample Size Sampling Serum Severities Severity of illness Statistical Models Susceptibility Gene Symptoms Testing Time Ulcerative Colitis Universities Variant base clinical Diagnosis clinical phenotype clinically relevant cohort disorder subtype follow-up genetic analysis genetic variant genome wide association study lymphoblastoid cell line microorganism antigen non-genetic programs response trait

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DESCRIPTION (provided by applicant): This proposal is submitted in response to the RFA DK-06-504 for continuing our role as a Genetic Research Center (GRC) of the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC). Cedars-Sinai Medical Center will collaborate with the University of Puerto Rico for this project; UPR will be responsible for recruiting IBD patients, and CSMC will be responsible for performing genetic tests (genotyping) and analyzing the results, looking for regions of the human genome that contain genes that increase the risk for IBD. The Puerto Rican population is particularly suited for this type of study; the population is a composite of Native-American, African, and Caucasian-European peoples that have mixed together genetically since the time of Columbus. This type of genetic analysis is termed "Mapping by Admixture Linkage Disequilibrium."

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