Importance of CGRP alpha in pain processing from the large intestine

CGRP α 在大肠疼痛处理中的重要性

• 批准号: nhmrc : 1105277
• 负责人: Prof Nicholas Spencer
• 金额: $ 37.68万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/importance-cgrp-alpha-large-intestine/662814
• 关键词: Importance; CGRP; alpha; pain; processing

This project will determine the mechanisms by which sensory nerve endings detect painful stimuli in the large intestine. The project will use a novel genetically modified mouse (that is only available in our laboratory) which allows us, for the first time, to visualize and record directly from the sensory nerve endings that detect painful stimuli and work out how this process occurs. We also identify a specific gene that is essential for detecting painful stimuli from this organ.

这个项目将确定感觉神经末梢检测大肠疼痛刺激的机制。该项目将使用一种新的转基因小鼠（仅在我们的实验室中可用），这使我们能够首次直接从感觉神经末梢观察和记录，这些感觉神经末梢检测到疼痛刺激，并找出这一过程是如何发生的。我们还确定了一个特定的基因，这是必不可少的检测疼痛刺激从这个器官。