A novel technique for prolonged silencing of visceral pain without opiates

一种无需阿片类药物即可长时间抑制内脏疼痛的新技术

• 批准号: nhmrc : GNT1127140
• 负责人: Prof Nicholas Spencer
• 金额: $ 63.74万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-technique-prolonged-pain-opiates/1347600
• 关键词: novel; technique; prolonged; silencing; visceral

There has been substantial interest in the community for pain relief without opiates. This project demonstrates a new strategy to suppress pain at the source for prolonged periods, by suppressing activity in the sensory nerve endings that detect pain, not by acting in central pathways like opiates. To do this, we use a harmless virus to shut down a vital sodium channel for pain perception. These experiments use techniques that were recently developed in our lab and cant be performed elsewhere.

社区对无阿片类药物的疼痛缓解有很大的兴趣。该项目展示了一种新的策略，通过抑制检测疼痛的感觉神经末梢的活动，而不是通过像阿片类药物那样在中枢通路中起作用，来长期抑制疼痛的根源。为了做到这一点，我们使用一种无害的病毒来关闭感知疼痛的重要钠通道。这些实验使用了我们实验室最近开发的技术，在其他地方无法进行。