PREVALENCE AND DETERMINANTS OF ORAL HPV INFECTION IN THE US POPULATION

美国人口腔 HPV 感染的患病率和决定因素

• 批准号: 8087141
• 负责人: MAURA L GILLISON
• 金额: $ 75.46万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8087141
• 关键词: Accounting; Affect; Age; Age-Years; Alcohol consumption; Behavior; Birth; Case-Control Studies; Caucasians; Caucasoid Race; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Collaborations; Cross-Sectional Studies; Data; Dental Epidemiology; Detection; Enrollment; Future; Gender; Genital system; Goals; HPV-High Risk; Head and Neck Squamous Cell Carcinoma; Health Status; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Incidence; Infection; Malignant Neoplasms; Marijuana Smoking; Medical Surveillance; Methods; Molecular; National Cancer Institute; National Health and Nutrition Examination Survey; Nutritional status; Oral; Oral cavity; Oropharyngeal; Participant; Pattern; Policies; Population; Populations at Risk; Prevalence; Primary Prevention; Public Health; Public Policy; Race; Research Design; Risk; Risk Factors; Sample Size; Sampling; Screening procedure; Sex Behavior; Surveys; Therapeutic; Time; Tobacco use; United States; United States National Center for Health Statistics; Vaccination; Vaccines; behavioral health; boys; cancer risk; cohort; disorder prevention; high risk; malignant mouth neoplasm; malignant oropharynx neoplasm; meetings; men; oral infection; population based; prevent; prophylactic; trend

DESCRIPTION (provided by applicant): Oral HPV16 infection is an established cause of oropharynx cancer, a cancer rising in incidence in the United States (U.S.), particularly among young, white men. Oral HPV16 infection confers an approximate 15-fold increased oropharynx cancer risk and has clear public health consequences. Yet, virtually nothing is known about the epidemiology of oral HPV infection. Our goal is to determine the prevalence and determinants (e.g. demographic, behavioral and health factors) of oral HPV infection in a representative sampling of the U.S. population. We hypothesize that differences in sexual behaviors by age, gender, race and birth cohort will account for patterns in oral HPV prevalence by these factors as well as for observed incidence patterns for HPV-related and HPV-unrelated HNSCC in the U.S. We have developed and validated methods for detection of oral HPV infection and demonstrated our ability to reproducibly detect infection over time. We have an established collaboration with the National Center for Health Statistics, the National Cancer Institute, and the Center for Disease Control and Prevention to perform a nested, cross-sectional study of oral HPV infection among 14 to 69 year old participants in the National Health and Nutrition Examination Survey (NHANES) 2009-2010, a population-based study designed to assess the health and nutritional status of the U.S. population. We now seek support to extend this study through 2014 to enroll the sample size necessary to achieve our aims, which are: (1) to determine the prevalence and type distribution of oral HPV infection in the U.S. population; (2) to identify demographic, behavioral and health factors independently associated with infection; (3) to evaluate the distribution of factors associated with oral HPV infection and HNSCC (e.g. sexual behavior, tobacco use, alcohol use, marijuana use) by age, gender, race and birth cohort and compare these to incidence patterns for HPV-related and HPV-unrelated HNSCC in the U.S. population. By accomplishing these aims, we will clarify the epidemiology of oral HPV infection, estimate the proportion of the U.S. population at risk for HPV-related HNSCC and identify birth cohorts at high risk. Our results may affect public policy or practice with regard to current HPV prophylactic vaccine policy for boys and will have future implications for the primary prevention of HNSCC via vaccination to prevent or screening to detect oral HPV infection. PUBLIC HEALTH RELEVANCE: By accomplishing the proposed aims, we will clarify the epidemiology of oral HPV infection in the U.S. population, estimate the proportion of the U.S. population at risk for HPV-positive HNSCC and identify birth cohorts at highest risk for HPV-HNSCC. Our results may also affect public policy or practice with regard to current HPV prophylactic vaccine policy for boys. The resulting data will also have future implications for the primary prevention of HNSCC via vaccination to prevent or screening to detect oral HPV infection.

描述（由申请人提供）：口腔HPV 16感染是口咽癌的一个既定原因，口咽癌是一种在美国（U.S.）发病率上升的癌症，尤其是年轻的白色男性。口腔HPV 16感染使口咽癌风险增加约15倍，并具有明显的公共卫生后果。然而，实际上对口腔HPV感染的流行病学一无所知。我们的目标是在美国人口的代表性抽样中确定口腔HPV感染的患病率和决定因素（例如人口统计学，行为和健康因素）。我们假设，年龄，性别，种族和出生队列的性行为差异将解释这些因素的口腔HPV患病率模式以及在美国观察到的HPV相关和HPV无关的HNSCC的发病率模式。我们已经开发并验证了检测口腔HPV感染的方法，并证明了我们随着时间的推移可重复检测感染的能力。我们与国家卫生统计中心、国家癌症研究所和疾病控制和预防中心建立了合作关系，在2009-2010年国家健康和营养检查调查（NHANES）中对14至69岁的参与者进行了一项口腔HPV感染的巢式横断面研究，这是一项以人口为基础的研究，旨在评估美国人口的健康和营养状况。我们现在寻求支持，将这项研究延长到2014年，以招募实现我们目标所需的样本量，这些目标是：（1）确定美国人口中口腔HPV感染的患病率和类型分布;（2）确定与感染独立相关的人口统计学，行为和健康因素;（3）探讨口腔HPV感染与HNSCC的相关因素分布（如性行为、吸烟、饮酒、吸食大麻），种族和出生队列，并将其与美国人群中HPV相关和HPV无关HNSCC的发病模式进行比较。通过实现这些目标，我们将阐明口腔HPV感染的流行病学，估计美国人口中HPV相关HNSCC的风险比例，并确定高风险的出生队列。我们的研究结果可能会影响公共政策或实践，关于目前的HPV预防性疫苗政策的男孩，并将有未来的影响，通过接种疫苗，以防止或筛查，以检测口腔HPV感染的HNSCC的一级预防。 公共卫生关系：通过实现提出的目标，我们将阐明美国人口中口腔HPV感染的流行病学，估计美国人口中HPV阳性HNSCC的风险比例，并确定HPV-HNSCC风险最高的出生队列。我们的研究结果也可能影响公共政策或实践，关于目前的HPV预防性疫苗政策的男孩。由此产生的数据也将对未来通过接种疫苗预防或筛查检测口腔HPV感染的HNSCC一级预防产生影响。