HOPE PILOT 2

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人乳头瘤病毒（HPV）是新近发现的头颈部鳞状细胞癌（HNSCC）的病原体。HPV是美国每年40，000例HNSCC发病病例中的20%。大多数HPV-HNSCC是口咽部的。必须确定口腔HPV感染的患病率、危险因素和自然史，以评估将HPV检测纳入口腔癌筛查的可能性，就像最近完成的宫颈癌筛查一样。我们已经验证了口腔HPV检测方法和口咽“巴氏涂片”等效方法。此外，我们已经描述了在HIV感染患者中致癌HPV类型引起的口腔感染的风险增加，这与他们已知的口咽癌风险增加6倍一致。该提案的目标是在高危人群（HIV感染患者）中进行口腔HPV感染的首次纵向研究，以深入了解口腔HPV感染的短期自然史。我们将研究112例HIV感染患者6个月内口腔HPV感染的患病率、发病率和清除模式，方法是每隔2周收集一系列口腔冲洗液、扁桃体刷检样本和行为问卷。这些数据是必要的设计两个大的，计划队列研究的病理后果口腔HPV感染的HIV感染者。筛查的益处将是通过早期治疗干预减少HPV相关HNSCC。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human papillomavirus (HPV) is a newly established etiologic agent for Head and Neck Squamous Cell Cancer (HNSCC). HPV is responsible for 20% of the 40,000 annual incident cases of HNSCC in the U.S. Most HPV-HNSCCs are oropharyngeal. Prevalence, risk factors and natural history of oral HPV infection must be determined to evaluate the potential for incorporation of HPV detection into oral cancer screening, as was recently accomplished for cervical cancer screening. We have validated methods for oral HPV detection and an oropharyngeal "Pap-smear" equivalent. Furthermore, we have delineated an increased risk for oral infection by oncogenic HPV types among HIV-infected patients, consistent with their known 6-fold increased risk for oropharyngeal cancer. The goal of this proposal is to perform the first longitudinal study of oral HPV infection in a high-risk group (HIV-infected patients) to gain insight into the short-term natural history of oral HPV infection. We will study the prevalence, incidence, and clearance patterns of oral HPV infection in 112 HIV-infected patients over 6 months by collecting serial oral rinses, tonsillar brush biopsy samples and behavioral questionnaires at 2-week intervals. These data are necessary for the design of two large, planned cohort studies of the pathological consequences of oral HPV infection in HIV-infected individuals. The benefit of screening will be a reduction in HPV-associated HNSCC through earlier therapeutic interventions.