HOPE PILOT 2

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人乳头瘤病毒(HPV)是一种新发现的头颈部鳞状细胞癌(HNSCC)病原体。在美国每年40,000例HNSCC病例中，HPV占20%。大多数HPV-HNSCC是口咽部的。必须确定口腔HPV感染的患病率、危险因素和自然病史，以评估将HPV检测纳入口腔癌筛查的可能性，就像最近在宫颈癌筛查中所完成的那样。我们已经验证了口腔HPV检测的方法和口咽“巴氏涂片”的等价物。此外，我们描述了HIV感染患者中致癌HPV型口腔感染的风险增加，这与他们口咽癌风险增加6倍的已知结果是一致的。这项建议的目标是在高危人群(艾滋病毒感染患者)中进行第一次口腔HPV感染的纵向研究，以深入了解口腔HPV感染的短期自然历史。我们将通过每隔两周收集连续口腔漱口、扁桃体刷检样本和行为问卷，研究112名HIV感染者6个月内口腔HPV感染的患病率、发病率和清除模式。这些数据对于设计两项大型、有计划的队列研究是必要的，这些研究是关于艾滋病毒感染者口腔HPV感染的病理后果的研究。筛查的好处将是通过早期治疗干预减少HPV相关的HNSCC。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human papillomavirus (HPV) is a newly established etiologic agent for Head and Neck Squamous Cell Cancer (HNSCC). HPV is responsible for 20% of the 40,000 annual incident cases of HNSCC in the U.S. Most HPV-HNSCCs are oropharyngeal. Prevalence, risk factors and natural history of oral HPV infection must be determined to evaluate the potential for incorporation of HPV detection into oral cancer screening, as was recently accomplished for cervical cancer screening. We have validated methods for oral HPV detection and an oropharyngeal "Pap-smear" equivalent. Furthermore, we have delineated an increased risk for oral infection by oncogenic HPV types among HIV-infected patients, consistent with their known 6-fold increased risk for oropharyngeal cancer. The goal of this proposal is to perform the first longitudinal study of oral HPV infection in a high-risk group (HIV-infected patients) to gain insight into the short-term natural history of oral HPV infection. We will study the prevalence, incidence, and clearance patterns of oral HPV infection in 112 HIV-infected patients over 6 months by collecting serial oral rinses, tonsillar brush biopsy samples and behavioral questionnaires at 2-week intervals. These data are necessary for the design of two large, planned cohort studies of the pathological consequences of oral HPV infection in HIV-infected individuals. The benefit of screening will be a reduction in HPV-associated HNSCC through earlier therapeutic interventions.