Training Program in Hypertension, Kidney Disease & Cell Biology

描述(由申请者提供)：本申请建议继续资助肾脏疾病、高血压和细胞生物学的跨学科研究培训计划。该计划的目的是为年轻的临床医生和科学家提供培训，他们对从事肾脏疾病、血压调节以及与肾脏生理和疾病相关的细胞生物学基本方面的研究生涯感兴趣。该计划的目标是1)寻找和招募优秀的受训人员，包括性别和种族，希望获得与肾脏疾病、高血压和细胞生物学相关的基础和应用研究的原理和技术的全面知识；2)提供高质量研究项目的设计和实施方面的培训，包括参加跨学科研究团队；3)提供多学科的综合指导研究经验，促进受训人员的职业生涯发展；4)增加训练有素的肾脏相关疾病研究人员队伍，他们将创建自我维持的创新研究计划，并有效地参与与肾脏研究相关的培训。受训者将从泌尿科、儿科肾脏科、肾脏科和基础科学等学科吸引学员。该计划的主要主题是提供一种手段，使积极进取的年轻医生和科学家能够在一位成熟和富有成效的教师导师的指导下，进行一段时间的密集和持续的研究培训。除了他们的主要导师外，所有学员都将有一个指导委员会。具体培训机会包括基础和应用细胞生物学、高血压的心血管和肾脏系统异常、肾脏发育生物学、泌尿生殖道癌生物学、肾脏免疫紊乱，以及肾脏和尿路疾病的临床和翻译调查。生理学、生物化学、药理学和免疫学等相关领域将提供更多机会。此外，申请者将有机会使用流行病学和统计学方法与调查人员合作。已有30多名教职员工表示愿意参加此类博士后候选人的培训。范围广泛的高度专业化的专门知识使这类培训几乎可以在任何与肾脏疾病有关的领域进行。 公共卫生相关性：肾脏疾病在美国人中是一个日益严重的问题。这一增加的原因尚不完全清楚，大多数肾脏疾病也知之甚少。肾脏疾病的治疗方法包括透析和肾移植，但这些治疗方法并不完美。这项申请建议继续培训科学家研究肾脏疾病、高血压和肾脏细胞生物学的计划。它包括对科学家进行临床问题方面的培训，包括疾病流行病学。 以及如何将实验室的发现转化为更好的治疗方法。更好地了解肾脏疾病可能会带来更好的治疗方法和更健康的人群。

DESCRIPTION (provided by applicant): This application proposes continued funding for an interdisciplinary research training program in kidney diseases, hypertension, and cell biology. The purpose of this program is to provide training for young clinicians and scientists interested in pursuing research careers involved in diseases of the kidney, regulation of the blood pressure, and basic aspects of cell biology as they relate to kidney physiology and disease. The goals of the program are 1) To identify and recruit outstanding trainees, inclusive of gender and ethnicity, who wish to obtain comprehensive knowledge of the principles and techniques of basic and applied research related to kidney disease, hypertension, and cell biology; 2) To offer training in the design and implementation of high quality research projects, including participation in cross-disciplinary research teams; 3) To provide multidisciplinary and integrated mentored research experiences which facilitate developing a trainee's professional career; 4) To increase the pool of well- trained researchers in diseases relating to the kidney who will create self-sustaining, innovative research programs and effectively participate in training related to kidney research. Trainees will be attracted from programs in urology, pediatric nephrology, nephrology, and the basic sciences. The major theme of the program is to provide the means whereby highly motivated young physicians and scientists can spend an intensive and sustained period of research training under the guidance of an established and productive faculty mentor. All trainees will have a mentoring committee in addition to their primary mentor. Specific training opportunities include the areas of basic and applied cell biology, abnormalities of the cardiovascular and renal systems in hypertension, developmental biology of the kidney, the biology of urogenital cancer, immunological disorders of the kidney, and clinical and translational investigation of diseases of the kidney and urinary tract. Additional opportunities will be available in related areas of physiology, biochemistry, pharmacology, and immunology. In addition, applicants will have the opportunity to work with investigators using epidemiologic and statistical methods. Over 30 faculty have indicated a willingness to participate in the trainin of such postdoctoral candidates. A broad range of highly specialized expertise permits such training in almost any area related to kidney diseases. PUBLIC HEALTH RELEVANCE: Kidney disease is a growing problem among people in the United States. The reasons for this increase are not completely known and most kidney disease is poorly understood. Therapies for kidney disease include dialysis and kidney transplantation, but these therapies are imperfect. This application proposes to continue a program to train scientists in the study of kidney disease, high blood pressure, and the biology of cells of the kidney. It includes training scientists in clinical problems including the epidemiology of diseases and how to translate discoveries in the laboratory into better therapies. A better understanding of kidney diseases may lead to better treatments and a healthier population.