Theoretically based treatment for sentence comprehension deficits in aphasia

描述(由申请者提供)：2010年健康人计划的一个目标是减少不同人群之间的健康差距。失语症患者句子理解障碍的诊断和治疗是一个仍然存在差异的领域，尽管这一主题具有重要的理论意义。然而，目前关于这一主题的研究缺乏具体的建议，即如何训练失语症患者的句子理解技能，以及在句法结构相似的句子和不同的理解任务之间，理解技能的概括程度如何。该项目的目标是开发一种有效的、理论上合理的治疗中风后失语症患者句子理解障碍的方法。我们开发针对这些缺陷的有效疗法的方法将以语言学、心理语言学和失语学的结果为指导。这个项目包括两个不同的阶段：第一阶段：R21(第一年)的具体计划和里程碑在项目的第一阶段(R21)，将持续一年，我们将开发两种有效的治疗句法理解障碍的方法-一种基于图片匹配，另一种基于物体设定。里程碑将是这些疗法有效性的衡量标准。今年，我们还将制定最佳治疗处方(治疗疗程的频率和持续时间)以及用于培训和推广的刺激。第二阶段：R33(第2-5年)在项目的第二阶段(R33)，我们将调查在第一阶段开发的治疗的更广泛的临床应用。我们将解决关键问题，如治疗项目的获得率、对未培训项目的推广、治疗终止后的表现保持、转移到日常理解任务以及为培训选择最佳的患者。这一阶段的预期结果是一种新的治疗方法，其临床效用具有良好的特点，可供临床医生与适当的失语症患者使用。

DESCRIPTION (provided by applicant): One goal of the Healthy People 2010 program is to reduce health disparities across different segments of the population. Diagnosis and treatment of sentence comprehension deficits in patients with aphasia is one area where disparities continue to exist even though this topic is of great theoretical importance. The current research on this topic, however, lacks specific recommendations on how to train sentence comprehension skills in patients with aphasia and to what extent generalization of comprehension skills occurs across sentences of similar syntactic structure and across different comprehension tasks. The goal of the project is to develop an effective, theoretically sound, treatment for sentence comprehension deficits in patients with aphasia following stroke. Our approach to developing effective therapies for these deficits will be guided by results in linguistics, psycholinguistics, and aphasiology. This project consists of two distinct phases: Phase 1: Specific Plans and Milestones for R21 (Year 1) In the first (R21) phase of the project, which will last one year, we will develop two effective therapies for syntactic comprehension deficits - one based on picture matching and one based on object enactment. Milestones will be measures of the effectiveness of these therapies. In this year, we will also develop the optimal treatment prescription (frequency and duration of therapy sessions) and the stimuli to be utilized for training and generalization. Phase 2: R33 (Years 2-5) in the second (R33) phase of the project, we will investigate the wider clinical utility of the treatment developed in Phase 1. We will address the critical issues of rate of acquisition of treated items, generalization to untrained items, maintenance of performance after termination of treatment, transfer to everyday comprehension tasks, and optimal patient selection for training. The expected outcome of this phase is a novel treatment approach whose clinical utility is well characterized and that can be used by clinicians with appropriate patients with aphasia.