头颈癌中的孢子-猫眼课题宝

头颈癌中的孢子

批准号：

8535391

负责人：

DAVID SIDRANSKY

金额：

$14.86万

依托单位：

JOHNS HOPKINS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-09-17 至 2017-07-31

来源：

https://reporter.nih.gov/project-details/8535391

关键词：

Algorithms Antibodies Area Attention Behavior Bioinformatics Biological Markers Biology Biometry Case-Control Studies Clinic Clinical Combined Modality Therapy Commit DNA Development Diagnosis Diagnostic Disease Early Diagnosis Epidemiology Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Etiology Exposure to Funding Generations Genomics Goals Grant Growth Factor Receptors Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Head and neck structure Heterogeneity Human Papilloma Virus Vaccine Human Papillomavirus Human body Immune response Immune system Immunologics Immunology Immunosuppression Immunotherapy Incidence Infection Laboratories Larynx Lead Malignant Neoplasms Measures Mediating Molecular Target Monitor Morbidity - disease rate Morphology Mutation Nasopharynx National Institute of Dental and Craniofacial Research Oral cavity Oropharyngeal Oropharyngeal Neoplasms Outcome Pathology Patients Peer Review Plasma Primary Lesion Protein Tyrosine Kinase Radiation Radiation Tolerance Radiation therapy Reproduction spores Research Research Personnel Research Project Grants Research Support Risk Risk Assessment Signal Transduction Pathway Site Specialized Program of Research Excellence Staging Testing Therapeutic Tissues Tobacco Tonsil Toxic effect Transforming Growth Factor beta Receptors Translational Research Tumor Burden United States National Institutes of Health Universities Vaccine Therapy Vaccines Work anticancer research base cancer genome cancer genomics cancer therapy career development flexibility genome sequencing improved innovation medical schools mortality multidisciplinary novel phosphoric diester hydrolase prevent prognostic programs response success tumor tumor progression

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英文摘要

This application for continuation for the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer at the Johns Hopkins University School of Medicine supports a highly interactive, multidisciplinary, and intrainstitutional program. Five research projects, three cores, a career development and a research developmental program are proposed to carry out our translational research in head and neck cancer. The SPORE has given attention in all projects to the presence and absence of HPV infection as a major determinant of disease biology and behavior. Moreover, there are two main themes that permeate our major projects, one is genomics and biology and the other is immunology. Research Project #1- Augmentation of Immune Response to Head and Neck Squamous Cell Carcinoma via Phosphodiesterase Type 5 Inhibition - Co-Investigators, Ivan Borrello (basic) and Joseph Califano (clinic). Research Project #2 - HNSCC From Cancer Genomics to Personalized Biomarkers. - Co-Investigators, David Sidransky (basic) and Nishant Agrawal (clinic). Research Project #3 - Improving EGFR-targeted Immunotherapy of HNSCC by Counteracting TGF- ¿ -mediated Immune Suppression - Co-Investigators, Christine Chung (clinic) and AtuI Bedl (basic). Research Project #4 - HPV Vaccine Therapy - Co-Investigators Sara Pal (clinic) and T.C. Wu (basic) Project #5 - Etiologic Heterogeneity in Head and Neck Squamous - Co-Investigators, Gypsyamber D'Souza (basic) and Carole Fakhry (clinic) The cores support the research programs (Core #1 - Pathology/ Tissue Core, Dr. Westra; and Core #2 - Administrative/Clinical Core (Dr. Sidransky), Core #3 - Biostatistics and Bioinformatics Core (Dr. Rosner) The Career Development Program(Dr. Sidransky) aids the emergence of new investigators and the Research Developmental Program (Dr. David Sidransky) provides rapid funding of innovative directions.

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