High Throughput Genetic Analysis of Bladder Cancer

膀胱癌的高通量遗传学分析

• 批准号: 7909202
• 负责人: DAVID SIDRANSKY
• 金额: $ 32.8万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7909202
• 关键词: Throughput; Genetic; Analysis; Bladder; Cancer

DESCRIPTION (provided by applicant): A program project is proposed by researchers at the Johns Hopkins Medical Institutions and the University of California at Berkeley entitled, "High Throughput Genetic Analysis of Bladder Cancer and Urine Sediment." The goals of this proposal are to improve our understanding of the molecular genetic changes that drive bladder cancer progression as we develop and integrate novel high throughput approaches for the detection of these genetic alterations. These approaches will be used to translate our findings into the clinical setting where we will evaluate genetic alterations as predictors of disease outcome and targets for molecular detection. Unlike traditional methods of isolated investigators, this program emphasizes sharing of subjects, tissue samples, resources, technical expertise and data analysis strategies. Our program will not only offer clinical direction for basic research efforts, but will also facilitate the direct translation of state of the art high throughput technology into the basic laboratory and clinical arena.

描述（由申请人提供）：约翰霍普金斯医疗机构和加州大学伯克利分校的研究人员提出了一个项目，题为“膀胱癌和尿沉渣的高重复性遗传分析”。“这项提案的目标是提高我们对推动膀胱癌进展的分子遗传变化的理解，因为我们开发和整合了用于检测这些遗传改变的新型高通量方法。这些方法将用于将我们的发现转化为临床环境，在临床环境中，我们将评估遗传改变作为疾病结果的预测因子和分子检测的靶点。与传统的孤立调查方法不同，该计划强调共享受试者，组织样本，资源，技术专长和数据分析策略。我们的计划不仅为基础研究工作提供临床方向，而且还将促进最先进的高通量技术直接转化为基础实验室和临床竞技场。

项目成果

Detection of mitochondrial deoxyribonucleic acid alterations in urine from urothelial cell carcinoma patients.

• DOI: 10.1002/ijc.26357
• 发表时间: 2012-07-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Dasgupta, Santanu;Shao, Chunbo;Keane, Thomas E.;Duberow, David P.;Mathies, Richard A.;Fisher, Paul B.;Kiemeney, Lambertus A.;Sidransky, David
• 通讯作者: Sidransky, David

Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells.

• DOI: 10.1002/ijc.24701
• 发表时间: 2009-12-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Dasgupta, Santanu;Hoque, Mohammad Obaidul;Upadhyay, Sunil;Sidransky, David
• 通讯作者: Sidransky, David

Integrated capillary electrophoresis microsystem for multiplex analysis of human respiratory viruses.

• DOI: 10.1021/ac1020744
• 发表时间: 2010-12-15
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Thaitrong, Numrin;Liu, Peng;Briese, Thomas;Lipkin, W. Ian;Chiesl, Thomas N.;Higa, Yukiko;Mathies, Richard A.
• 通讯作者: Mathies, Richard A.

Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer

• DOI: 10.1002/1097-0215(20001120)89:6<514::aid-ijc8>3.0.co;2-h
• 发表时间: 2000-11-20
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Chow, NH;Cairns, P;Sidransky, D
• 通讯作者: Sidransky, D

Fluorescence labeling methods for microchannel plate capillary electrophoresis DNA sizing.

用于微通道板毛细管电泳 DNA 大小测定的荧光标记方法。

• 发表时间: 2002
• 期刊: Journal of capillary electrophoresis and microchip technology
• 作者: Medintz,Igor;Wong,WendyW;Mathies,RichardA
• 通讯作者: Mathies,RichardA