Biomedical Informatics

项目总结(见说明)： OSUCCC生物医学信息学共享资源(BISR)的使命是通过向终端用户提供先进的生物医学信息学服务和专业知识，推动整个OSUCCC的癌症研究。最终用户包括OSUCCC领导层、研究人员、研究人员、受训人员和其他共享资源(SR)和科学计划(SP)。在上一个CCSG奖励周期中，BISR是一种发展中的共享资源，在本周期中将作为一种完全共享资源。BISR通过一系列机制完成其任务，包括以下具体服务：1)定制、部署和管理caBIG技术和平台，以支持临床和生物分子数据管理和集成需求；2)执行需要生物信息学和计算生物学专业知识的复杂数据分析；以及3)生物医学信息学 咨询、项目规划和培训。BISR由两个相辅相成的部门组成，侧重于计算生物学服务(CBS)和数据管理服务(DMS)。BISR的CBS部门为终端用户提供服务，包括规划和执行特定于SP或SR的数据管理应用程序和分析工作流程，重点是利用高通量生物数据，例如OSUCCC仪器SRS生成的数据。的DMS部门 BISR提供技术服务和专业知识，支持采用、定制和使用caBIG技术和平台，以促进特定于SP和SR的数据管理需求，重点是提供数据分析管道，使最终用户能够识别、集成、交换和分析异类和分布式数据集/源。此外，DMS的ARM 促进OSUCCC最终用户访问企业范围的临床信息学工具和数据源，例如医疗中心的信息仓库(一个全面的企业范围的数据仓库)，以及由CTSA资助的OSU临床和转化科学中心(CCTS)正在开发的数据管理工具和资源。BISR在整个OSUCCC中扮演着催化剂的角色，将实验室的发现整合并迅速转化为癌症治疗和预防。

PROJECT SUMMARY (See instructions): The mission of the OSUCCC Biomedical Informatics Shared Resource (BISR) is to advance cancer research throughout the OSUCCC by providing end-users with advanced biomedical informatics services and expertise. End-users include OSUCCC leadership, investigators, research staff, trainees, and other shared resources (SRs) and scientific programs (SPs). In the last CCSG award cycle, the BISR was a developing shared resource and in this cycle will serve as a full shared resource. The BISR accomplishes its mission through a number of mechanisms, including the following specific services: 1) customization, deployment, and management of caBIG technologies and platforms in support of clinical and bio-molecular data management and integration requirements; 2) the execution of complex data analyses that require bioinformatics and computational-biology expertise; and 3) biomedical informatics consulting, project planning, and training. The BISR is organized into two complementary arms, focusing on Computational Biology Services (CBS) and Data Management Services (DMS). The CBS arm of the BISR provides end-users with services, including the planning and execution of SP- or SR-specific data management applications and analytical workflows, with an emphasis on the utilization of high throughput biological data, such as that generated by OSUCCC instrumentation SRs. The DMS arm of the BISR provides technical services and expertise in support of the adoption, customization, and use of caBIG technologies and platforms to facilitate SP- and SR-specific data management requirements, with an emphasis on the provision of data-analytic pipelines that enable end-users to identify, integrate, exchange, and analyze heterogeneous and distributed data sets/sources. In addition, the DMS arm facilitates OSUCCC end-user access to enterprise-wide clinical informatics tools and data sources, such as the Medical Center's Information Warehouse (a comprehensive enterprise-wide data warehouse), as well as the data management tools and resources being developed by the CTSA-funded OSU Center for Clinical and Translational Science (CCTS). The BISR serves as a catalyst throughout the OSUCCC to integrate and rapidly translate discoveries from the lab to cancer treatment and prevention.