Bioinformatics

生物信息学

• 批准号: 8246047
• 负责人: JEFFREY D PARVIN
• 金额: $ 16.32万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246047
• 关键词: Affect; Binding; Biochemical Genetics; Bioinformatics; Biological; Biological Markers; Biostatistics Core; Cell Communication; Cells; Chromatin; Clinical; Complex; Computational Science; Consultations; DNA; Data; Decision Making; Elements; Ensure; Gene Expression; Genes; Human; Informatics; Instruction; Laboratories; Mammary Neoplasms; Mammary gland; Measures; Messenger RNA; Methods; MicroRNAs; Microarray Analysis; Molecular Profiling; Mus; Outcome; Output; Pathway interactions; Patients; Population; RNA; Regulator Genes; Research Personnel; Resources; Sampling; Sequence Analysis; Tissues; Tumor Suppressor Proteins; Work; base; cell behavior; cell type; clinical decision-making; data integration; genetic analysis; high throughput analysis; histone modification; human disease; malignant breast neoplasm; mouse model; programs; research study; response; tool; transcription factor; tumor; tumorigenic

The principal objective of the Bioinformatics Core will be to provide project investigators a resource for bioinformatics analysis and interpretation of high throughput experiments performed in each project. In support of this objective, the specific aims of the Bioinformatics Core B include: 1. Analysis of ChlP-seq results 2. Analysis of microarray or RNA-seq measures of mRNA and miRNA abundance 3. Identify biological networks that operate among different cell types in the tumor microenvironment 4. Develop decision-making tools for TME biomarkers and human relevance

生物信息学核心的主要目标是为项目调查人员提供一种用于生物信息学分析的资源，并解释每个项目中执行的高吞吐量实验。为了支持这一目标，生物信息学核心B的具体目的包括： 1。分析CHLP-seq结果 2。分析mRNA和miRNA丰度的微阵列或RNA-seq度量 3。确定肿瘤微环境中不同细胞类型之间运行的生物网络 4。为TME生物标志物和人类相关性开发决策工具