14th Annual Midwest DNA Repair Symposium

描述（由申请人提供）：本提案的总体目标是为将于2012年5月19日至20日在俄亥俄州辛辛那提市辛辛那提大学举行的第14届中西部DNA修复年度研讨会（AMDRS）筹集资金，辛辛那提儿童医院医学中心（CCHMC）将作为联合主办机构。AMDRS是一个区域性会议，汇集了来自中西部研究DNA损伤/修复及其与癌症的关系的研究人员。DNA修复途径是维持基因组稳定性所必需的，修复途径的缺失会导致基因组突变和肿瘤发生。DNA修复和修复途径的调节也可以影响化疗药物的效果。AMDRS具有高质量的科学程序，但价格实惠，方便。因此，它吸引了来自中西部各地的各种各样的研究人员。它为学生，博士后研究员和年轻的pi提供了一个极好的机会来展示他们的工作并与高级研究人员互动。它受到高级pi的喜爱，因为它的科学质量和与邻近机构的同事互动的独特机会。它也吸引了那些有能力的私人侦探

DESCRIPTION (provided by applicant): The overall objective of this proposal is to secure funding to support the 14th Annual Midwest DNA repair Symposium (AMDRS) to be held May 19-20, 2012 at the University of Cincinnati, Cincinnati, OH, with Cincinnati Children's Hospital Medical Center (CCHMC) as co-host. AMDRS is a regional conference that brings together researchers from across the Midwest who study DNA damage/repair and how it relates to cancer. DNA repair pathways are required to maintain genomic stability with loss of repair pathways leading to genomic mutations and tumorigenesis. DNA repair and regulation of repair pathways can also influence the effect of chemotherapeutic agents. The AMDRS has a high quality scientific program but is affordable and convenient. Consequently, it attracts a diverse array of researchers from across the Midwest. It provides an excellent opportunity for students, post-doctoral fellows and young PIs to present their work and to interact with senior investigators. It is enjoyed by senior PIs because of the scientific quality and the unique opportunity to interact with colleagues from neighboring institutions. It also attracts PIs who are interested in DNA damage/repair but who work in peripheral areas and would not normally attend a national DNA repair meeting. The program will include keynote lectures from prominent scientists, four sessions of short talks and two poster sessions. There will be a focus on new technology/approaches relevant to the intersection between DNA damage/repair and cancer development, detection and treatment. The aims of the conference are: To provide a venue for DNA repair researchers, principally from the Midwestern states, to present recent progress in their research programs, to network with other investigators and to form new collaborations. 2. To provide a venue for graduate students, postdoctoral fellows and young investigators to present their research among peers and to interact with leaders in the field. 3. To provide an affordable but high quality scientific meeting that allows participation from the diverse constituents of the DNA repair community. PUBLIC HEALTH RELEVANCE: This proposal seeks funding to support a regional conference focusing on DNA repair and its relevance to cancer development, detection and treatment. The conference will attract a diverse group of researchers from across the Midwest and hence will help disseminate information that will enhance our understanding of the relationship between DNA damage/repair and tumorigenesis and how this relationship can be exploited in cancer diagnosis and treatment.