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Genetic Engineering Mouse Core

Genetic Engineering Mouse Core
基因工程鼠标核心
批准号:
8052127
负责人:
RONALD ANTHONY DEPINHO
金额:
$8.38万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-01-01 至 2011-12-31

项目摘要

项目成果

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中文摘要
翻译
基因工程小鼠(GEM)菌株的构建和表型分析是基础
英文摘要
The construction and phenotypic analysis of genetically engineered mouse (GEM) strains are fundamental and integral for the study of pancreatic cancer, including the analysis of signaling molecules in this pathology, the discovery and analysis of novel genes and their linked networks, and the validation and assessment of novel therapeutic targets and associated molecular biomarkers. The Genetic Engineering Mouse Core (GEMC) of this PDAC POI will provide all the necessary expertise, reagents and services to generate four genetically engineered mouse (GEM) modeling projects per year of grant funding. The GEMC will work closely with POI project leaders, investigators to produce the most advanced cancer relevant GEM strains. Specifically: (A) Transgenics; the GEMC will support all aspects of the construction of transgenic mouse models, including advice, service, technologies and reagents for the optimal design and construction of each specific transgene. (B) Gene Targeting; We will support all aspects of the construction of knockout and knock-in mouse alleles, including provide services, support, advice, technologies and reagents for the optimal design, construction and production of each specific targeting vector and resulting mice. (C) Evaluate and implement new technologies for the construction of genetically engineered mice and derivative cells.
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会议论文
Identifying and targeting collateral lethal vulnerabilities in cancers
Exploring Collateral Lethality for Development of Cancer Therapeutics
Genetics and Biology of Metastatic Colorectal Cancer
Exploring Collateral Lethality for Development of Cancer Therapeutics
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