Natriuretic Peptide Receptor and Cardiomyocyte Biology

利尿钠肽受体和心肌细胞生物学

• 批准号: 8203706
• 负责人: Margaret M Redfield
• 金额: $ 38.85万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8203706
• 关键词: Ablation; Acceleration; Affect; Attention; Biology; Canis familiaris; Cardiac; Cardiac Myocytes; Cardiovascular system; Catabolism; Chronic; Clinical; Collagen; Cyclic GMP; Diastolic heart failure; Disease Progression; Dominant-Negative Mutation; Elderly woman; Fibrosis; Foundations; Functional disorder; Funding; Future; Gene Delivery; General Population; Genes; Guidelines; Heart; Heart failure; High Prevalence; Hospitals; Human; Hypertension; Hypertrophy; Image; Impairment; In Vitro; Kidney; Lung; Mammals; Medicine; Modeling; Mus; Natriuretic Peptides; Particulate; Patients; Peptide Receptor; Peptides; Phenotype; Physiology; Population; Prevalence; Principal Investigator; Proteins; Public Health; Pulmonary Hypertension; Recombinant adeno-associated virus (rAAV); Registries; Reporting; Residual state; Rodent; Serotyping; Signal Transduction; Stress; Supportive care; System; Techniques; Time; Translations; Venous; Viral; Wild Type Mouse; atrial natriuretic factor receptor A; base; effective therapy; improved; in vivo; inhibitor/antagonist; mortality; mutant; novel; novel strategies; novel therapeutics; overexpression; phosphoric diester hydrolase; pre-clinical; pressure; prevent; professor; programs; protective effect; protein expression; receptor; response; restoration; saluretic; single photon emission computed tomography; sodium-iodide symporter; vector; viral gene delivery

Program Director/Principal Investigator (Last, First, Middle): Burnett, John. C. Jr. PROJECT 1 Title: Natriuretic Peptide Receptor and Cardiomyocyte Biology Project Descripfion: This proposal seeks to develop a novel, cardiac specific and ulfimately translatable therapy for diastolic heart failure (DHF) based on the cardiac specific over-expression of the natriuretic pepfide receptor (guanylyl cyclase A (GCA)) via adeno-associated viral (AAV) gene delivery. We will optimize overexpression of GCA in rodent heart, demonstrate that restoration of cardiac GCA via gene delivery prevents heart failure in GCA deficient mice (mice witli systemic (GCA"uit) and mice witti cardiac specific (CS- GCAnuii) ablation ofthe GCA gene) and reverses heart failure in wild type mice with established DHF. These studies lay the foundation for translation to large mammal and human DHF in future studies. Project Leader: Margaret M. Redfield. MD; Professor of Medicine Other

项目主管/首席研究员（最后、第一、中）：Burnett, John。c . Jr .)