NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 8249398
• 负责人: LEIF D NELIN
• 金额: $ 27.18万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249398
• 关键词: Address; Admission activity; Affect; American; Biometry; Birth; Bronchopulmonary Dysplasia; Chronic; Clinical; Clinical Protocols; Clinical Research; Coupled; Data; Data Set; Development; Disease; Genes; Genetic; Gestational Age; Health; Health Care Costs; Healthcare Systems; Housing; Infant; Infant Care; Institution; Maintenance; Medicine; Methodology; Mission; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Nature; Neonatal; Neonatology; Nursing Faculty; Ohio; Outcome; Patients; Pediatric Hospitals; Pediatric Research; Perinatal; Population; Population Heterogeneity; Predisposition; Premature Birth; Premature Infant; Principal Investigator; Productivity; Research; Research Design; Research Infrastructure; Research Institute; Resources; Risk; Series; Services; Site; Strategic Planning; Stress; Telemedicine; Testing; Universities; Work; adverse outcome; clinical material; feeding; fetal medicine; follow-up; genome wide association study; high risk; improved; infant death; innovation; member; multidisciplinary; premature; prevent; programs; public health relevance; response

DESCRIPTION (provided by applicant): The Division of Neonatology of Nationwide Children's Hospital and The Ohio State University submits this application to join the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network in response to RFA-HD-10-003. Strengths of our Institution include: 1) a truly academic Division that consists of 19 clinical faculty members with an exceptional record of clinical research, 2) a large and medically diverse population available for clinical studies with 2,197 NICU admissions in 2009 of which 615 were <= 32 weeks gestational age and 539 were <1500 grams birthweight, 3) a vibrant collaborative relationship with maternal-fetal medicine and a long and successful relationship between our institution and the NICHD MFMU, 4) a dynamic Center for Perinatal Research housed in the Research Institute, which includes a vigorous clinical research enterprise the Ohio Perinatal Research Network, and 5) a robust Institutional commitment to preventing prematurity and its complications. Indeed, preventing prematurity is the focus of NCH's strategic plan. All of these strengths will contribute greatly to NICHD NRN studies. Furthermore, our population is very receptive and agreeable to participation in clinical studies related to preterm birth. Our clinical capabilities are far reaching and include essentially every service offered to preterm neonates. We have a neonatal follow-up program that has proven to be particularly well suited to follow-up of subjects in clinical protocols. Our concept application entitled, "Developing a Personalized Medicine Approach to Preterm Infants", brings together neonatology, genetics, mathematical medicine, and biostatistics to develop a personalized medicine approach to the complications of prematurity. This concept application demonstrates our expertise in acquiring, storing and analyzing vast data sets. This expertise will be necessary for any "omic" types of studies that the NICHD NRN may undertake in the years to come. Our assets, abundant clinical material, outstanding institutional support, exceptional collegiality between MFM and neonatology, the resources of a dedicated pediatric research institute, and outstanding academic neonatologists make NCH/OSU an ideal site for the NICHD NRN. PUBLIC HEALTH RELEVANCE: The burden to the American health care system of prematurity is immense, responsible for ~67% of all infant deaths and health care costs of $26 billion a year. Collaborative efforts to gather high quality evidence to prevent and improve the adverse outcomes of prematurity are desperately needed, and the NICHD Neonatal Research Network is the foremost mechanism for gathering such high quality neonatal evidence.

描述(由申请人提供)：国家儿童医院和俄亥俄州立大学新生儿科根据RFA-HD-10-003提交申请，加入尤尼斯·肯尼迪·施莱弗NICHD多中心合作新生儿研究网络。我们研究所的优势包括：1)由19名临床教员组成的真正的学术部门，他们在临床研究方面有着非凡的记录；2)2009年有2,197名NICU患者可用于临床研究，其中615名孕妇=32周，539名孕妇；3)与母婴医学的密切合作关系，以及我们机构与NICHD MFMU之间长期而成功的合作关系；4)位于研究所内的充满活力的围产期研究中心，其中包括一个充满活力的临床研究企业--俄亥俄州围产期研究网络；以及5)机构对预防早产及其并发症的坚定承诺。事实上，防止早熟是NCH战略计划的重点。所有这些优势都将对NICHD NRN研究做出巨大贡献。此外，我们的人口非常愿意并乐于参与与早产有关的临床研究。我们的临床能力是深远的，基本上包括为早产儿提供的所有服务。我们有一个新生儿随访计划，已被证明特别适合在临床方案中对受试者进行随访。我们的概念应用程序名为“为早产儿开发个性化医学方法”，将新生儿学、遗传学、数学医学和生物统计学结合在一起，以开发针对早产儿并发症的个性化医学方法。这一概念应用展示了我们在获取、存储和分析海量数据集方面的专业知识。这种专业知识对于NICHD NRN在未来几年可能进行的任何“学术”类型的研究都是必要的。我们的资产、丰富的临床材料、出色的机构支持、MFM和新生儿学之间的卓越合作、专门的儿科研究所的资源以及杰出的学术新生儿专家使NCH/OSU成为NICHD NRN的理想地点。 与公共卫生相关：早产给美国医疗保健系统带来的负担是巨大的，占所有婴儿死亡人数的67%，每年的医疗费用为260亿美元。迫切需要合作努力收集高质量的证据，以预防和改善早产的不良后果，而NICHD新生儿研究网络是收集这种高质量新生儿证据的首要机制。