NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 8081504
• 负责人: LEIF D NELIN
• 金额: $ 27.23万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8081504
• 关键词: Address; Admission activity; Affect; American; Biometry; Birth; Bronchopulmonary Dysplasia; Chronic; Clinical; Clinical Protocols; Clinical Research; Coupled; Data; Data Set; Development; Disease; Genes; Genetic; Gestational Age; Health; Health Care Costs; Healthcare Systems; Housing; Infant; Infant Care; Institution; Maintenance; Medicine; Methodology; Mission; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Nature; Neonatal; Neonatology; Nursing Faculty; Ohio; Outcome; Patients; Pediatric Hospitals; Pediatric Research; Perinatal; Population; Population Heterogeneity; Predisposition; Premature Birth; Premature Infant; Principal Investigator; Productivity; Research; Research Design; Research Infrastructure; Research Institute; Resources; Risk; Series; Services; Site; Strategic Planning; Stress; Telemedicine; Testing; Universities; Work; adverse outcome; clinical material; feeding; fetal medicine; follow-up; genome wide association study; high risk; improved; infant death; innovation; member; multidisciplinary; premature; prevent; programs; response

DESCRIPTION (provided by applicant): The Division of Neonatology of Nationwide Children's Hospital and The Ohio State University submits this application to join the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network in response to RFA-HD-10-003. Strengths of our Institution include: 1) a truly academic Division that consists of 19 clinical faculty members with an exceptional record of clinical research, 2) a large and medically diverse population available for clinical studies with 2,197 NICU admissions in 2009 of which 615 were <= 32 weeks gestational age and 539 were <1500 grams birthweight, 3) a vibrant collaborative relationship with maternal-fetal medicine and a long and successful relationship between our institution and the NICHD MFMU, 4) a dynamic Center for Perinatal Research housed in the Research Institute, which includes a vigorous clinical research enterprise the Ohio Perinatal Research Network, and 5) a robust Institutional commitment to preventing prematurity and its complications. Indeed, preventing prematurity is the focus of NCH's strategic plan. All of these strengths will contribute greatly to NICHD NRN studies. Furthermore, our population is very receptive and agreeable to participation in clinical studies related to preterm birth. Our clinical capabilities are far reaching and include essentially every service offered to preterm neonates. We have a neonatal follow-up program that has proven to be particularly well suited to follow-up of subjects in clinical protocols. Our concept application entitled, "Developing a Personalized Medicine Approach to Preterm Infants", brings together neonatology, genetics, mathematical medicine, and biostatistics to develop a personalized medicine approach to the complications of prematurity. This concept application demonstrates our expertise in acquiring, storing and analyzing vast data sets. This expertise will be necessary for any "omic" types of studies that the NICHD NRN may undertake in the years to come. Our assets, abundant clinical material, outstanding institutional support, exceptional collegiality between MFM and neonatology, the resources of a dedicated pediatric research institute, and outstanding academic neonatologists make NCH/OSU an ideal site for the NICHD NRN. PUBLIC HEALTH RELEVANCE: The burden to the American health care system of prematurity is immense, responsible for ~67% of all infant deaths and health care costs of $26 billion a year. Collaborative efforts to gather high quality evidence to prevent and improve the adverse outcomes of prematurity are desperately needed, and the NICHD Neonatal Research Network is the foremost mechanism for gathering such high quality neonatal evidence.

描述（由申请人提供）：全国儿童医院新生儿科和俄亥俄州立大学根据 RFA-HD-10-003 提交了加入 Eunice Kennedy Shriver NICHD 合作多中心新生儿研究网络的申请。我们机构的优势包括：1) 一个真正的学术部门，由 19 名临床研究人员组成，拥有出色的临床研究记录；2) 拥有大量可用于临床研究的医学多样化人群，2009 年 NICU 入院人数为 2,197 人，其中 615 人胎龄 <= 32 周，539 人出生体重 <1500 克，3) 与母胎医学充满活力的合作关系，以及与母胎医学之间长期成功的关系。 我们的机构和 NICHD MFMU，4) 研究所内的一个充满活力的围产期研究中心，其中包括一个充满活力的临床研究企业俄亥俄州围产期研究网络，以及 5) 对预防早产及其并发症的强有力的机构承诺。事实上，预防早产是 NCH 战略计划的重点。所有这些优势都将为 NICHD NRN 研究做出巨大贡献。此外，我们的人民非常愿意参与与早产相关的临床研究。我们的临床能力影响深远，基本上包括为早产儿提供的每一项服务。我们有一个新生儿随访计划，已被证明特别适合临床方案中受试者的随访。我们的概念应用题为“针对早产儿开发个性化医学方法”，汇集了新生儿学、遗传学、数学医学和生物统计学，开发针对早产儿并发症的个性化医学方法。这一概念应用展示了我们在获取、存储和分析大量数据集方面的专业知识。这种专业知识对于 NICHD NRN 在未来几年可能开展的任何“组学”类型的研究都是必要的。我们的资产、丰富的临床材料、出色的机构支持、MFM 和新生儿学之间的卓越合作、专门儿科研究所的资源以及杰出的新生儿学术专家，使 NCH/OSU 成为 NICHD NRN 的理想场所。 公共健康相关性：早产儿给美国医疗保健系统带来了巨大的负担，约占所有婴儿死亡的 67%，每年的医疗保健费用高达 260 亿美元。迫切需要共同努力收集高质量的证据，以预防和改善早产的不良后果，而 NICHD 新生儿研究网络是收集此类高质量新生儿证据的最重要机制。