Pediatric Traumatic Brain Injury in Latin America

描述（由申请人提供）：拉丁美洲创伤性脑损伤（TBI）的发病率是国际平均水平的三倍。在世界范围内，TBI是儿童和青少年死亡和残疾的主要原因。由于非神经系统的继发性并发症如败血症和肺炎导致的死亡率和发病率很高。TBI的出院后康复很少或根本没有，对这些患者的随访护理也很少见。治疗实践因中心和地区而异。在资源允许的情况下，许多中心使用婴儿，儿童和青少年TBI急性医学管理指南来指导他们的治疗决策。试点数据表明，这样做可能会改善结果。迫切需要对拉丁美洲的儿科TBI进行强有力的研究，以进行诊断，治疗和预防。我们建议在拉丁美洲的儿科患者中进行TBI研究。它将在五个创伤中心进行;三个在阿根廷，一个在玻利维亚，一个在厄瓜多尔。这些中心代表了拉丁美洲可用于治疗TBI的资源的变化。我们的具体目标是：1。在一项随机对照试验中，测试家庭提供的家庭护理干预对中度至重度TBI儿科患者功能结局的影响。2.在一项前瞻性、观察性研究中，测试严重TBI儿科患者的医疗管理和结局之间的关联。3.在一项前瞻性、观察性研究中，测试资源可用性与中重度TBI儿科患者结局之间的相关性。4.建立一个长期的，前瞻性收集的数据在拉丁美洲的儿科TBI，可用于生成强有力的科学文献，诊断，治疗，预后和预防指南-适合资源贫乏的环境-可以派生。5.建立拉丁美洲脑损伤联盟（LABIC）的可持续能力，在患有神经创伤和其他重大脑部疾病的儿科人群中进行持续研究。我们估计样本为720例急性护理患者;我们预计65%将存活至出院，并将收集约420例患者的结局数据（占10%的失访）。我们假设，随机分配到家庭护理干预的患者将有显着更好的功能状态比那些谁不接受干预。我们进一步假设，结果将显着相关的资源水平，并与医疗管理。公共卫生相关性：创伤性脑损伤（TBI）是一个重大的公共卫生问题。在世界范围内，它是儿童和青少年死亡和残疾的主要原因。由于道路交通事故和暴力，拉丁美洲是世界上颅内损伤发生率最高的地区。拉丁美洲儿童TBI的发病率几乎是国际平均水平的三倍。创伤性脑损伤的康复治疗在拉丁美洲的大部分地区都很少见，只有特权阶层或有保险的人才能享受。幸存者出院回家，过着残疾、孤立和耻辱的生活，没有后续护理。儿童创伤性脑损伤患者的疾病负担尤其沉重，因为这些儿童无法重返学校或在社区从事生产活动，而是多年完全依赖家人生活。

DESCRIPTION (provided by applicant): The incidence of traumatic brain injury (TBI) in Latin America is three times the international average. Worldwide, TBI is the leading cause of death and disability among children and adolescents. Mortality and morbidity due to non- neurological, secondary complications such as sepsis and pneumonia are high. There is little to no post-discharge rehabilitation for TBI, and follow-up care for these patients is rare. Treatment practices vary across centers and regions. Where resources allow, many centers use the Guidelines for the Acute Medical Management of TBI in Infants, Children, and Adolescents to guide their treatment decisions. Pilot data suggests that doing so may improve outcomes. There is an urgent need to conduct strong research about pediatric TBI in Latin America that can lead to diagnostics, treatment, and prevention. We propose to conduct a study of TBI in pediatric patients in Latin America. It will take place in five trauma centers; three in Argentina, one in Bolivia, and one in Ecuador. These centers represent the variation in resources available for treatment of TBI in Latin America. Our Specific Aims are: 1. In a randomized controlled trial, test the effect of a family-provided home care intervention on functional outcomes for pediatric patients who sustain moderate to severe TBI. 2. In a prospective, observational study, test the association between medical management and outcomes for pediatric patients with severe TBI. 3. In a prospective, observational study, test the association between resource availability and outcomes for pediatric patients with moderate to severe TBI. 4. Establish a registry of long-term, prospectively collected data about pediatric TBI in Latin America that can be used to generate strong scientific literature from which diagnostic, treatment, prognostic, and prevention guidelines - appropriate to resource-poor environments - can be derived. 5. Establish sustainable capacity in the Latin American Brain Injury Consortium (LABIC) to conduct ongoing research in pediatric populations with neurotrauma and other significant brain disorders. Our estimated sample is 720 acute care patients; we anticipate 65% will survive to discharge, and will collect outcomes data on approximately 420 patients (accounting for 10% loss to follow-up). We hypothesize that patients randomized to the home care intervention will have significantly better functional status than those who do not receive the intervention. We further hypothesize that outcome will be significantly associated with level of resources, and with medical management. PUBLIC HEALTH RELEVANCE: Traumatic brain injury (TBI) is of significant public health concern. Worldwide, it is the leading cause of death and disability among children and adolescents. Latin America has the highest incidence of intracranial injury in the world due to road traffic accidents and violence. The incidence of TBI in children in Latin America is almost three times higher than the international average. Rehabilitation for TBI is rare in most of Latin America - available only to the privileged or the employee-insured. Survivors are discharged to their families to live a life of disability, isolation, and stigma, with no follow-up care. The burden of illness is particularly poignant for pediatric TBI patients, as these children cannot return to school or engage in productive activities in their communities, but live many years completely dependent upon their families.