Imaging Core

成像核心

• 批准号: 8324707
• 负责人: katsuo kurbayashi
• 金额: $ 16.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8324707
• 关键词: Address; Algorithms; Area; Biomedical Engineering; Biopsy; Calibration; Characteristics; Clinical; Clinical Data; Collection; Computer software; Core Facility; Data; Data Collection; Detection; Development; Diagnostic; Dimensions; Doctor of Philosophy; Documentation; Dyes; Endoscopes; Endoscopy; Engineering; Evaluation; Fluorescence; Future; Gastrointestinal tract structure; Home environment; Human Resources; Image; Imaging Techniques; Institutional Review Boards; Instruction; Japan; Label; Lead; Light; Maintenance; Maps; Medical; Methods; Michigan; Microscope; Mission; Modification; Neoplasm Metastasis; Neoplasms; Optics; Pathology; Penetration; Peptides; Performance; Physicians; Process; Research; Resources; Safety; Scanning; Signal Transduction; Site; Speed; Standardization; System; Teleconferences; Testing; Tissues; Tokyo; Training; Training Support; Universities; Work; base; clinical research site; design; fluorescence imaging; follow-up; image processing; imaging modality; improved; innovation; instrument; instrumentation; neoplastic; operation; prototype; repaired; seal

Imaging - The overall mission of the Imaging Core is to provide the resources, personnel, and training needed to develop, modify, repair, and implement the multi-modality imaging platform for data collection, processing, and evaluation at the clinical sites of the proposed NTR Research Center. The Core Director is Katsuo Kurabayashi, PhD at the University of Michigan who will oversee the operation of this resource, and will address the needs of each clinical site for proper function, calibration, and standardization of the wide area endoscope and confocal microscope imaging systems used for clinical data collection. In addition, he will direct the development of new endoscope compatible instruments that provide improved imaging performance, such as the dual axes confocal microscope that can image in vertical cross-sections with over 500 (am tissue penetration to assess for neoplastic invasion and micro-metastases. Sakae Takehana is the Core Co-Director and will be responsible for providing the wide area endoscopy systems for imaging the fluorescent-labeled peptides from Olympus Medical Systems Corp in Tokyo, Japan. In addition, he will lead the effort to tune the fluorescence filter specifications on the Lucera videoendoscope to optimize signal collection from the dye and to develop near-infrared fluorescence imaging techniques in the future. Rolf Wolters, PhD is also a Core Co-Director and is from STI Medical Systems Inc in Honolulu, HI. He will be responsible for providing image processing software to perform registration of the multi-modal images, including the white light and fluorescence data from the videoendoscope. Dr Wolters will work closely with the Site Directors and CRAs from each clinical center to analyze the video data, provide imagie registration and correlation to pathology, and develop diagnostic maps to help the clinician identify dysplastic regions for guiding tissue biopsy. Because of the large geographical distance between the home facilities of the Core Directors, they will discuss the NTR Core imaging instrumentation needs via teleconference on a bi-weekly basis. Implementation and follow up of action items will be performed in the appropriate optical engineering lab, including 1) Olympus Medical Systems Corp for modification, tuning, and repair of the Lucera videoendoscopes, 2) STI Medical Systems Inc for modification, trouble-shooting, and debugging of image processing and feature extraction software, and 3) University of Michigan Medical Innovations Center for the design, prototyping and fabrication of the dual axes confocal microscope.

成像 - 成像核心的总体使命是提供资源，人员和 为数据开发，修改，修复和实施多模式成像平台所需的培训 在拟议的NTR研究中心的临床部位收集，处理和评估。核心 导演是密歇根大学的Katuo Kurabayashi博士，他将监督此操作 资源，并将满足每个临床部位的需求，以适当的功能，校准和标准化 用于临床数据收集的宽面积内窥镜和共聚焦显微镜成像系统。在 此外，他将指导提供改进的新内窥镜兼容仪器的开发 成像性能，例如双轴共聚焦显微镜，可以在垂直横截面中与 超过500（AM组织穿透以评估肿瘤侵袭和微焦点。 核心联合导演，将负责提供广泛的内窥镜检查系统，以成像 来自日本东京奥林巴斯医疗系统公司的荧光标记肽。此外，他将领导 调整Lucera视频管镜上荧光滤波器规范的努力以优化信号 从染料收集并在将来开发近红外荧光成像技术。罗尔夫 沃尔特斯（Wolters）博士也是核心联合导演，来自HI HI的STI Medical Systems Inc。他会的 负责提供图像处理软件以执行多模式图像的注册， 包括来自视频镜的白光和荧光数据。沃尔特博士将与 来自每个临床中心的现场主管和CRA，以分析视频数据，提供图像注册和 与病理学的相关性，并开发诊断图，以帮助临床医生识别出异常区域 指导组织活检。因为核心的房屋设施之间的地理距离很大 导演，他们将通过每两周一次的电话会议讨论NTR核心成像仪器的需求 基础。在适当的光学工程中将执行实施和行动项目的随访 实验室，包括1）Olympus Medical Systems Corp进行修改，调整和修复Lucera VideoEndoscopes，2）STI Medical Systems Inc用于修改，故障射击和图像调试 处理和功能提取软件，以及3）密歇根大学医学创新中心 双轴共聚焦显微镜的设计，原型和制造。