Sensitivity to smoking reinforcement in women: menstrual cycle effects

女性对吸烟强化的敏感性：月经周期影响

• 批准号: 8113478
• 负责人: Elizabeth Van Voorhees
• 金额: $ 7.85万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8113478
• 关键词: Address; Affect; Age; Animal Experimentation; Behavioral; Biological Factors; Cigarette; Cognitive Therapy; Complex; Consumption; Cotinine; Cues; Data; Development; Estrogens; Feeling; Female; Foundations; Gender; Goals; Health; Hormonal; Intervention Studies; Investigation; Luteal Phase; Measures; Mediating; Menstrual cycle; Mental disorders; Moods; Nicotine; Nicotine Dependence; Nicotine Withdrawal; Outcome; Ovarian hormone; Patient Self-Report; Pharmaceutical Preparations; Phase; Physiological; Pilot Projects; Play; Population; Process; Progesterone; Psychological reinforcement; Psychopathology; Recruitment Activity; Research; Research Design; Research Project Grants; Rewards; Role; Sensory; Sex Characteristics; Smoker; Smoking; Smoking Behavior; Smoking Status; Source; Symptoms; System; Taste Perception; Techniques; Time; Withdrawal; Withholding Treatment; Woman; base; cigarette smoking; design; experience; improved; men; nicotine gum; nicotine patch; nicotine replacement; non-drug; novel; programs; proliferative phase Menstrual cycle; reward processing; satisfaction; sex; smoking cessation; social

DESCRIPTION (provided by applicant): Smoking-related outcomes vary by gender. Compared to men, women more rapidly increase their cigarette consumption after they begin smoking, have more difficulty discontinuing their use once they become dependent, and respond more poorly to smoking cessation treatments involving exclusively nicotine replacement therapy. Social, cultural, and biological factors likely interact to contribute to gender differences in smoking outcomes. However, studies demonstrating differences in smoking cessation outcomes across the menstrual cycle, as well as animal research implicating a role for ovarian hormones in nicotine-related reinforcement, suggest that hormonal mechanisms may be paramount. Ovarian hormones have been shown to affect sensitivity to both drug- and non-drug-related reinforcement via interactions with the dopaminergically mediated reward-processing system, and alterations in this system are implicated in nicotine dependence as well as a range of other psychiatric disorders. Despite the potential relevance to understanding gender differences in smoking outcomes, the role of ovarian hormones in sensitivity to the reinforcement of cigarette smoking has not been studied. The overall goal of this investigation is to systematically examine the effects of menstrual phase on the positive and negative reinforcing effects of cigarettes in female smokers. We will recruit 40 healthy female smokers between the ages of 18 and 45 to participate in a repeated measures research design. A Progressive Ratio (PR) task will be used to measure smoking reinforcement; cotinine, estrogen, and progesterone levels will be measured to verify smoking status and menstrual cycle phase; and mood, smoking behavior, and subjective experience of smoking will be examined using self-report measures. Specific aims include the following: 1) to characterize the role of menstrual phase on the behaviorally reinforcing effects of cigarettes in female smokers using a PR task; 2) to characterize the role of menstrual phase on the subjectively reinforcing effects of cigarettes in female smokers using self-report measures; and 3) to examine the relationship of menstrual cycle-related fluctuations in estrogen levels, progesterone levels, and estrogen/progesterone ratios on the behaviorally and subjectively reinforcing effects of cigarettes. This project will serve as a pilot study to determine the feasibility and relevance of a larger study examining potential hormonal mechanisms of gender differences in smoking outcomes and their relevance to treatment. The results may contribute to the development of novel treatments tailored to address the unique behavioral and physiological needs of female smokers, particularly those who suffer from comorbid psychopathology associated with dysreguation of reinforcement processes. PUBLIC HEALTH RELEVANCE: Compared to men, women more rapidly increase their cigarette consumption after they begin smoking, have more difficulty discontinuing their use once they become dependent, and respond more poorly to smoking cessation treatments involving exclusively nicotine replacement therapy. This research project is designed to improve understanding of mechanisms associated with increased cigarette smoking in women, thereby addressing a significant health issue that is relevant to a large segment of the population.

描述（由申请人提供）：吸烟相关的结果因性别而异。与男性相比，女性在开始吸烟后更快地增加吸烟量，一旦上瘾就更难停止吸烟，并且对仅涉及尼古丁替代疗法的戒烟治疗反应更差。社会、文化和生物因素可能相互作用，导致吸烟结果的性别差异。然而，研究表明，在整个月经周期的戒烟结果的差异，以及动物研究暗示在尼古丁相关的强化卵巢激素的作用，表明激素机制可能是至关重要的。卵巢激素已被证明通过与多巴胺能介导的奖励处理系统的相互作用影响对药物和非药物相关强化的敏感性，并且该系统的改变与尼古丁依赖以及一系列其他精神疾病有关。尽管了解吸烟结果的性别差异具有潜在的相关性，但尚未研究卵巢激素在吸烟强化敏感性中的作用。本研究的总体目标是系统地研究月经期对女性吸烟者吸烟的积极和消极强化作用的影响。我们将招募40名年龄在18岁至45岁之间的健康女性吸烟者参加重复测量研究设计。将使用累进比率（PR）任务来测量吸烟强化;将测量可替宁、雌激素和孕酮水平以验证吸烟状态和月经周期阶段;将使用自我报告测量来检查情绪、吸烟行为和吸烟的主观体验。具体目标包括：1）使用PR任务描述女性吸烟者月经期对香烟行为强化效应的作用; 2）使用自我报告测量描述女性吸烟者月经期对香烟主观强化效应的作用;以及3）检查与月经周期相关的雌激素水平，孕激素水平，和雌激素/孕激素比例对香烟的行为和主观强化作用的影响。该项目将作为一项试点研究，以确定一项更大规模研究的可行性和相关性，该研究将研究吸烟结果中性别差异的潜在激素机制及其与治疗的相关性。这些结果可能有助于开发针对女性吸烟者独特的行为和生理需求的新型治疗方法，特别是那些患有与强化过程失调相关的共病精神病理学的女性。 公共卫生相关性：与男性相比，女性在开始吸烟后更快地增加吸烟量，一旦上瘾就更难停止吸烟，并且对仅涉及尼古丁替代疗法的戒烟治疗反应更差。该研究项目旨在提高对与妇女吸烟增加有关的机制的认识，从而解决与大部分人口有关的重大健康问题。