Exercise Effects on Serum Biomarkers of Angiogenesis

运动对血管生成血清生物标志物的影响

• 批准号: 8131576
• 负责人: Catherine Rose Duggan
• 金额: $ 8.8万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8131576
• 关键词: Abdomen; Adherence; Aerobic; Aerobic Exercise; Affect; Androgens; Anthropometry; Area; Behavior; Biological; Biological Factors; Biological Markers; Biology; Blood; Blood Vessels; Body Composition; Body fat; Body mass index; C-reactive protein; Colon Carcinoma; DEXA; Data; Data Collection; Development; Diet; Dose; Estrogens; Exercise; Fasting; Fatty acid glycerol esters; Funding; Future; Glucose; Goals; Gonadal Steroid Hormones; Growth; Growth Factor; Guidelines; Health; Home environment; Human; IGF1 gene; Insulin; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 3; Intervention; Intervention Studies; Intervention Trial; Intra-abdominal; Investigation; Knowledge; Laboratories; Leptin; Life Style; Link; Lipids; Literature; Long-Term Effects; Malignant Neoplasms; Mammographic Density; Measures; National Cancer Institute; Obesity; Overweight; Participant; Patient Self-Report; Physical activity; Plasminogen Activator Inhibitor 1; Population; Postmenopause; Prolactin; Proteins; Public Health; Randomized; Randomized Controlled Trials; Research Priority; Resources; Risk; Risk Factors; Risk Reduction; Sample Size; Serum; Serum Proteins; Serum amyloid A protein; Somatomedins; Steroids; Stretching; Testing; Tissues; United States Dept. of Health and Human Services; Vascular Endothelial Growth Factors; Woman; aged; angiogenesis; anticancer research; base; behavior change; cancer risk; cancer type; cost effective; energy balance; fitness; ghrelin; human data; interest; intervention effect; malignant breast neoplasm; meetings; novel; osteopontin; outcome forecast; pigment epithelium-derived factor; programs; randomized trial; sedentary; steroid hormone; subcutaneous; tumor growth

DESCRIPTION (provided by applicant): Increased physical activity is associated with a decreased risk of several types of cancer, but the underlying mechanisms for these associations are still poorly understood. The National Cancer Institute has identified investigations into the mechanisms linking energy balance and its components (physical activity, diet, obesity) and cancer as being a high priority for research. Physical activity may alter cancer risk through diverse mechanisms such as effects on insulin resistance, steroid hormones, and various growth factors. Less explored potential mechanisms include angiogenesis, which is required for tumor growth promotion. Physical activity may affect these biomarkers through changes in adiposity. Therefore, we propose to investigate the effect of moderate intensity exercise on blood levels of cancer biomarkers related to angiogenesis in 170 overweight/obese sedentary women who were part of a randomized controlled exercise intervention trial (86 Exercise Intervention and 84 Controls; Physical Activity for Total Health, R01 CA 69334; PI: McTiernan, Seattle, USA). The exercise intervention was a 1-year moderate intensity facility and home-based aerobic exercise program, 45 minutes/day, 5 days/week vs. stretching control. 98% of participants completed 12-month trial data collection and the intervention participants completed a mean 88% of the goal 225 minutes/week of activity. These women are well characterized in terms of self-reported diet and physical activity, anthropometry, body composition, and blood biomarkers, including sex hormones, insulin, C-reactive protein, and others. The specific aims of the study are to test the effect of 1-year exercise intervention vs. control in postmenopausal sedentary, overweight/obese women on serum concentrations of the angiogenic markers vascular endothelial growth factor (VEGF), osteopontin, pigment epithelium-derived factor (PEDF) and plasminogen activator inhibitor-1(PAI-1). To help understand the biologic mechanism, we will explore whether intervention effects differ by BMI or body composition prior to the intervention, or are dependent on amount of physical activity performed or on changes in body composition during the trial. The proposed study represents a unique opportunity to expand knowledge about the effects of physical activity on angiogenesis-related biomarkers, in a cost-effective and comprehensive manner by using an existing resource.

描述（由申请人提供）：增加体力活动与几种类型癌症的风险降低有关，但这些关联的潜在机制仍然知之甚少。国家癌症研究所已确定将能量平衡及其组成部分（体育活动，饮食，肥胖）与癌症联系起来的机制的研究作为研究的高度优先事项。身体活动可能通过多种机制改变癌症风险，例如对胰岛素抵抗，类固醇激素和各种生长因子的影响。较少探索的潜在机制包括血管生成，这是促进肿瘤生长所必需的。体力活动可能会通过改变肥胖来影响这些生物标志物。因此，我们建议研究中等强度运动对170名超重/肥胖久坐女性血液中血管生成相关癌症生物标志物水平的影响，这些女性是随机对照运动干预试验的一部分（86名运动干预和84名对照;身体活动促进全面健康，R 01 CA 69334; PI：McTiernan，西雅图，美国）。运动干预是一个为期1年的中等强度设施和家庭有氧运动计划，45分钟/天，5天/周与拉伸控制。98%的参与者完成了12个月的试验数据收集，干预参与者完成了平均88%的目标225分钟/周的活动。这些女性在自我报告的饮食和身体活动，人体测量，身体成分和血液生物标志物（包括性激素，胰岛素，C反应蛋白等）方面得到了很好的表征。本研究的具体目的是测试1年运动干预与对照对绝经后久坐、超重/肥胖女性血管生成标志物血管内皮生长因子（VEGF）、骨桥蛋白、色素上皮衍生因子（PEDF）和纤溶酶原激活物抑制剂-1（派-1）血清浓度的影响。为了帮助理解生物学机制，我们将探讨干预效果是否因干预前的BMI或身体成分而异，或者是否取决于试验期间进行的体力活动量或身体成分的变化。这项拟议的研究代表了一个独特的机会，通过使用现有资源，以具有成本效益和全面的方式，扩大有关身体活动对血管生成相关生物标志物影响的知识。