EXPERIMENTAL IRRADITOR

共享资源描述 自1986年以来一直存在的实验辐照器核心维护和操作电离辐射源，供Sidney Kimmel综合癌症中心(SKCCC)成员在其实验研究中使用。资源工作人员提供的服务包括：对放射源的操作进行培训，就使用辐射的实验设计向用户提供咨询意见，安排放射源的使用时间，在必要时操作源，为新的实验设置进行剂量测定，以及资源的维护和维修。当会员不使用这些设施时，非会员也可以按增加的费用使用这些设施。该设施的主要资源是五个Cs-137辐照器和一个图像导引正压X射线管辐照器(SARRP)。两个Nordion Gammacell 40照射器主要用于啮齿动物的全身照射或以恒定剂量率照射附着的培养细胞。牧羊人Mark I照射器主要用于向动物肿瘤或其他部分身体照射提供辐射，其剂量率与体外放射治疗中使用的剂量率相当。然而，这种辐照器可以提供广泛范围的剂量率的辐射，用于各种目的，如照射细胞悬浮液或照射到高剂量以消毒植入材料。Gammacell 1000辐照器用于以恒定剂量率照射悬浮培养物。这种低剂量率辐照器由Shepherd 81源内部制造，主要用于以与放射性植入物用于肿瘤治疗的剂量率相当的剂量率照射细胞培养物，但可以提供低于2GY/小时的任何速率的辐射，还被用于长期暴露在低剂量率辐射下的致癌研究。一个内部构建的图像引导小动物辐射研究平台(SARRP)现已提供给Core设施，该平台位于David Koch癌症研究大楼(CRBll)。SARRP的设计目的是在动物模型中产生与目前在人类患者身上可以达到的相同程度的剂量传递精度。实验辐照器核心允许研究人员将特定剂量的辐射传输到广泛的生物材料和活动物。根据研究人员的实验设计，这些仪器可以照射血液产品、动物全身或将辐射束照射到老鼠身上的小肿瘤。 SKCCC托管共享资源 本资助年度报告期：2010年1月1日至2010年12月31日

DESCRIPTION OF SHARED RESOURCE The Experimental Irradiator Core, which has been in existence since 1986, maintains and operates sources of ionizing radiation for use by Sidney Kimmel Comprehensive Cancer Center (SKCCC) members in their experimental studies. Services performed by the resource staff include training in the operation of the sources, advice to users on the design of experiments using radiation, scheduling use of the sources, operating the sources when necessary, dosimetry for new experimental setups, and maintenance and repair of the resources. When not in use by members, these facilities are also available to non-members on an increased-fee basis. The primary resources of the facility are five Cs-137 irradiators and one image guided orthovoltage x-ray tube irradiator (SARRP). Two Nordion Gammacell 40 in-adiators are primarily used for whole body irradiation of rodents or irradiation of attached cultured cells at a constant dose rate. The Shepherd Mark I irradiator is used primarily to deliver radiation to animal tumors or other partial-body irradiations at dose rates comparable to those used in external beam radiotherapy. However, this irradiator can deliver radiation at a broad range of dose rates for a variety of purposes, such as irradiation of cell suspensions or irradiation to high doses to sterilize implant material. The Gammacell 1000 irradiator is used to irradiate suspension cultures at a constant dose rate. The low-dose-rate irradiator, built in-house with a Shepherd 81 source, is used primarily to irradiate cell cultures at dose rates comparable to those used in tumor therapy with radioactive implants, but can deliver radiation at any rate below two Gy/hr and has also been used in studies of carcinogenesis from prolonged exposure to low-dose-rate radiation. An in-house built image-guided small animal radiation research platform (SARRP) is now available to the Core facility and is located in the David Koch Cancer Research Building (CRBll). The SARRP is designed to produce the same degree of dose delivery precision in animal models as is currently achievable in human patients. Lay The Experimental Irradiator Core allows researchers to deliver specific doses of radiation to a wide range of biological materials and live animals. Depending on a researcher's experimental design, these instruments can irradiate blood products, whole bodies of animals or direct a radiation beam to a small tumor on a mouse. SKCCC Managed Shared Resource Current Grant Year Reporting Period: January 1, 2010 to December 31, 2010