Experimental Irradiators

项目总结/摘要 实验辐照器共享资源（EISR）维护和操作电离源 Sidney Kimmel综合癌症中心用于实验和临床前研究的辐射 （SKCCC）成员。该资源支持在DNA损伤，癌症生物学，辐射 生物学、免疫学以及使用细胞模型的临床前和转化研究;异种移植、原位和 同基因肿瘤模型;和癌症的高级遗传修饰小鼠模型。提供服务 包括仪器操作方面的培训，就仪器的设计向用户提供咨询， 实验、治疗计划（剂量测定）和对用户进行新技术教育。资源工作人员 监督所有仪器操作，必要时协助用户操作仪器，并进行 适当的仪器维护和维修。上的非成员也可以使用该资源。 在不使用时增加费用。EISR资源包括平行对置双X射线 源系统，X射线源系统，图像引导正电压小动物辐射研究 SARRP平台和两个Cs-137辐照器。位于SKCCC癌症研究中心的SARRP II号楼配备了机载锥形束CT，用于指导小动物的精确局部照射， 模仿人体放射治疗SARRP最初代表高度复杂的技术 在约翰霍普金斯开发，并正在不断发展，以纳入分子光学 （生物发光和荧光）断层扫描用于反应评估。这些进步为用户提供了 在与临床相关的模型系统中进行精确辐射治疗和测试的无与伦比的机会 翻译. SKCCC托管共享资源 报告期：2020年1月1日至2020年12月31日

PROJECT SUMMARY/ABSTRACT The Experimental Irradiators Shared Resource (EISR) maintains and operates sources of ionizing radiation for use in experimental and preclinical studies by Sidney Kimmel Comprehensive Cancer Center (SKCCC) Members. The resource supports discovery research in DNA damage, cancer biology, radiation biology, immunology and preclinical and translational research using cell models; xenograft, orthotopic and syngeneic tumor models; and advanced genetically modified mouse models of cancer. Services performed by the resource staff include training in the operation of the instruments, advising users on the design of experiments, treatment planning (dosimetry) and educating users on new technologies. Resource staff oversee all instrument operations, assist users and operate the instruments when necessary, and conduct appropriate instrument maintenance and repair. The resource is also available to nonmembers on an increased-fee basis when not in use by Members. EISR resources include a parallel-opposed dual X-ray source system, an X-ray source system, an image-guided orthovoltage small-animal radiation research platform (SARRP) and two Cs-137 irradiators. The SARRP, located in the SKCCC Cancer Research Building II, is equipped with onboard cone beam CT to guide precise focal irradiation of small animals, mimicking human radiation treatments. SARRP represents highly sophisticated technology initially developed at Johns Hopkins and is under continuous development to incorporate molecular optical (bioluminescence and fluorescence) tomography for response assessment. These advances offer users unparalleled opportunities for precision radiation treatments and testing in model systems relevant for clinical translation. SKCCC Managed Shared Resource Reporting Period: January 1, 2020 to December 31, 2020