Fixation using Alternative Implants for the Treatment of Hip Fractures: A Multi-c

使用替代植入物进行固定治疗髋部骨折:Multi-c

基本信息

  • 批准号:
    8142946
  • 负责人:
  • 金额:
    $ 26.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-15 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Project Summary Hip fractures occur in 280,000 Americans (over 5,000 per week) and 36,000 Canadians (over 690 per week) annually. Hip fractures are associated with a 30% mortality rate at 1 year and profound temporary, and sometimes permanent, impairment of independence and quality of life. Worldwide, 4.5 million persons are disabled from hip fractures yearly with an expected increase to 21 million persons living with disability in the next 40 years. Hip fractures account for more hospital days than any other musculoskeletal injury and represent more than two thirds of all hospital days due to fractures. The disability adjusted life-years lost as a result of hip fractures ranks in the top 10 of all cause disability globally. Identifying the optimal approach to internal fixation is likely to improve the lives of tens of thousands of patients. Our primary objective is to assess the impact of sliding hip screws versus cannulated screw fixation on rates of revision surgery at 2 years in individuals with femoral neck fractures. Our secondary objective is to determine the impact on health-related quality of like (Short Form-12, SF-12), functional outcomes (Western Ontario McMaster Osteoarthritis Index, WOMAC) and health utility (Euro-Qol-5D, EQ-5D). We propose a multi-center, concealed randomized trial design using minimization to determine patient allocation. Surgeons will use one of two surgical strategies in patients who have sustained a femoral neck fracture. The first strategy involves fixation of the fracture with multiple small diameter cancellous screws (i.e., cancellous screw group). The second treatment strategy involves fixation of the fracture with a single larger diameter screw with a side plate (i.e., sliding hip screw group). Study personnel will monitor critical aspects of peri-operative care and rehabilitation for protocol deviations. We will assess patients at hospital discharge, 2 weeks, 10 weeks, 3 months, 6 months, 9 months, 12 months, 18 months, and 24 months after surgery. The primary outcome is revision surgery within 2 years of the initial surgery. The secondary outcomes include patient quality of life (Short Form-12, SF-12), function (Western Ontario McMaster Osteoarthritis Index, WOMAC), and health utility (EuroQol-5D, EQ-5D). We will independently adjudicate revision surgery rates at regular intervals up to 2 years. This trial will not only change current orthopaedic practice, but will set a benchmark for the conduct of future orthopaedic trials.
描述(由申请人提供):

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Subspecialty Fellowship Training Is Not Associated With Better Outcomes in Fixation of Low-Energy Femoral Neck Fractures-An Analysis of the Fixation Using Alternative Implants for the Treatment of Hip Fractures Database.
  • DOI:
    10.1097/bot.0000000000002264
  • 发表时间:
    2022-04-01
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    DeAngelis RD;Stein MK;Minutillo GT;Mehta NG;Schemitsch EH;Bzovsky S;Sprague S;Bhandari M;Swiontkowski M;Donegan DJ;Mehta S;FAITH Investigators
  • 通讯作者:
    FAITH Investigators
Patients With Femoral Neck Fractures Are at Risk for Conversion to Arthroplasty After Internal Fixation: A Machine-learning Algorithm.
  • DOI:
    10.1097/corr.0000000000002283
  • 发表时间:
    2022-12-01
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    van de Kuit, Anouk;Oosterhoff, Jacobien H. F.;Dijkstra, Hidde;Sprague, Sheila;Bzovsky, Sofia;Bhandari, Mohit;Swiontkowski, Marc;Schemitsch, Emil H. H.;IJpma, Frank F. A.;Poolman, Rudolf W. W.;Doornberg, Job N. N.;Hendrickx, Laurent A. M.
  • 通讯作者:
    Hendrickx, Laurent A. M.
Factors Associated With Revision Surgery After Internal Fixation of Hip Fractures.
  • DOI:
    10.1097/bot.0000000000001162
  • 发表时间:
    2018-05
  • 期刊:
  • 影响因子:
    2.3
  • 作者:
    Sprague S;Schemitsch EH;Swiontkowski M;Della Rocca GJ;Jeray KJ;Liew S;Slobogean GP;Bzovsky S;Heels-Ansdell D;Zhou Q;Bhandari M;FAITH Investigators
  • 通讯作者:
    FAITH Investigators
Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience.
在多中心随机对照试验中,中央协调作为本地协调的替代方案:FAITH 试验经验。
  • DOI:
    10.1186/1745-6215-13-5
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Zielinski,StephanieM;Viveiros,Helena;Heetveld,MartinJ;Swiontkowski,MarcF;Bhandari,Mohit;Patka,Peter;VanLieshout,EstherMM;FAITHtrialinvestigators
  • 通讯作者:
    FAITHtrialinvestigators
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial.
  • DOI:
    10.1016/s0140-6736(17)30066-1
  • 发表时间:
    2017-04-15
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) Investigators
  • 通讯作者:
    Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) Investigators
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Marc F. Swiontkowski其他文献

Reamed versus Non-Reamed Tibial Intramedullary Nailing
  • DOI:
    10.1007/s00068-003-1323-3
  • 发表时间:
    2003-10-01
  • 期刊:
  • 影响因子:
    2.200
  • 作者:
    Mohit Bhandari;Paul Tornetta;Marc F. Swiontkowski;Beate Hanson;Sheila Sprague;Emil H. Schemitsch;Gordon H. Guyatt
  • 通讯作者:
    Gordon H. Guyatt

Marc F. Swiontkowski的其他文献

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{{ truncateString('Marc F. Swiontkowski', 18)}}的其他基金

Addressing the prescription opioid crisis from the provider side- optimizing research and intervention design for maximum impact on public health
从提供方解决处方阿片类药物危机——优化研究和干预设计,以最大程度地影响公共卫生
  • 批准号:
    9912244
  • 财政年份:
    2019
  • 资助金额:
    $ 26.31万
  • 项目类别:
Fixation using Alternative Implants for the Treatment of Hip Fractures: A Multi-c
使用替代植入物进行固定治疗髋部骨折:Multi-c
  • 批准号:
    7686815
  • 财政年份:
    2008
  • 资助金额:
    $ 26.31万
  • 项目类别:
Fixation using Alternative Implants for the Treatment of Hip Fractures: A Multi-c
使用替代植入物进行固定治疗髋部骨折:Multi-c
  • 批准号:
    7515956
  • 财政年份:
    2008
  • 资助金额:
    $ 26.31万
  • 项目类别:
Fixation using Alternative Implants for the Treatment of Hip Fractures: A Multi-c
使用替代植入物进行固定治疗髋部骨折:Multi-c
  • 批准号:
    7902140
  • 财政年份:
    2008
  • 资助金额:
    $ 26.31万
  • 项目类别:
SPRINT- Randomized Trial of Tibial Fracture Fixation
SPRINT- 胫骨骨折固定的随机试验
  • 批准号:
    6458137
  • 财政年份:
    2002
  • 资助金额:
    $ 26.31万
  • 项目类别:
SPRINT- Randomized Trial of Tibial Fracture Fixation
SPRINT- 胫骨骨折固定的随机试验
  • 批准号:
    7169352
  • 财政年份:
    2002
  • 资助金额:
    $ 26.31万
  • 项目类别:
SPRINT- Randomized Trial of Tibial Fracture Fixation
SPRINT- 胫骨骨折固定的随机试验
  • 批准号:
    6732006
  • 财政年份:
    2002
  • 资助金额:
    $ 26.31万
  • 项目类别:
SPRINT- Randomized Trial of Tibial Fracture Fixation
SPRINT- 胫骨骨折固定的随机试验
  • 批准号:
    6622838
  • 财政年份:
    2002
  • 资助金额:
    $ 26.31万
  • 项目类别:
DEVELOPMENT OF AN EXTREMITY TRAUMA OUTCOME SCALE
肢体创伤结果量表的制定
  • 批准号:
    2202406
  • 财政年份:
    1992
  • 资助金额:
    $ 26.31万
  • 项目类别:
DEVELOPMENT OF AN EXTREMITY TRAUMA OUTCOME SCALE
肢体创伤结果量表的制定
  • 批准号:
    3331458
  • 财政年份:
    1992
  • 资助金额:
    $ 26.31万
  • 项目类别:

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