UTPA - Cancer Center at UTHSCSA Border Partnership (1 of 2)

UTPA - UTHSCSA 边境合作癌症中心（1 of 2）

• 批准号: 8323003
• 负责人: Bimal K Banik
• 金额: $ 7.29万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323003
• 关键词: Address; Affinity; American; Amides; Amines; Antineoplastic Agents; Apoptosis; Apoptotic; Aromatic Compounds; Attitude; Basic Science; Binding; Biological; Cancer Biology; Cancer Burden; Cancer Center; Cell Death; Cell Survival; Chrysenes; Clinical Trials; Communities; Decision Making; Effectiveness; Electrons; Fostering; Genetic screening method; Goals; Health Sciences; Hispanics; Human; In Vitro; Laboratories; Latino; Lead; Learning; Malignant Neoplasms; Measures; Metabolism; Methods; Mexico; Minority; Mus; Natural Killer Cells; Normal tissue morphology; Pathway interactions; Pilot Projects; Play; Population; Postdoctoral Fellow; Preparation; Process; Research; Research Personnel; Research Training; Role; Side; South Texas; Students; System; T-Lymphocyte; TdT-Mediated dUTP Nick End Labeling Assay; Testing; Texas; Toxic effect; Training; Training Programs; Translational Research; Tumor Cell Line; Universities; Work; alkalinity; analog; anticancer research; base; cancer education; cancer risk; cancer therapy; caspase-3; graduate student; health disparity; in vivo; interest; leukemia; malignant breast neoplasm; programs; tumor

DESCRIPTION (provided by applicant): The Latino/Hispanic population is the largest minority in the US and the highest concentration of Latinos is along the US-Mexico Border. To address the specific needs of this population in cancer research and education, a partnership between The University of Texas-Pan American and the Cancer Center at The University of Texas Health Science Center at San Antonio is proposed. The goals of this application are to develop research and training partnerships to increase the cancer research base on the US-Mexico border. The projects proposed will not only develop translational research in basic science but also address cancer related health disparities in the Hispanic border population. The specific goals of the application are: 1. to develop and foster cancer research at UTPA; 2. to foster research dedicated towards reducing the cancer burden of the Hispanic population with emphasis on the US-Mexico border, and 3. to increase the number of cancer researchers coming from South Texas. To accomplish these goals, two pilot projects and a training program are proposed. The first pilot project is a basic science project which will take advantage of the expertise at UTPA to synthesize polycyclic aromatic compounds and expertise at UTHSCSA to test these compounds as anticancer agents. The second pilot project is directed toward understanding the attitudes and decision making processes in genetic testing for increased breast cancer risk. The third project is a summer undergraduate program for UTPA students to work in laboratories and to learn about cancer biology with the goal of increasing the number of students from communities in South Texas interested in cancer research. This multidimensional approach will heighten cancer research and education in the Hispanic/Latino population along the Texas border.

描述（由申请人提供）：拉丁裔/西班牙裔人口是美国最大的少数民族，拉丁裔人口最集中的地区是沿着美墨边境。为了满足这一人群在癌症研究和教育方面的具体需求，德克萨斯大学泛美分校和位于圣安东尼奥的德克萨斯大学健康科学中心癌症中心之间建立了伙伴关系。该申请的目标是发展研究和培训伙伴关系，以增加美国-墨西哥边境的癌症研究基地。拟议的项目不仅将发展基础科学的转化研究，还将解决西班牙裔边境人口中与癌症相关的健康差距。该应用程序的具体目标是：1。发展和促进UTPA的癌症研究; 2.促进致力于减少西班牙裔人口癌症负担的研究，重点是美国-墨西哥边境，以及3.增加来自南德克萨斯州的癌症研究人员的数量。为了实现这些目标，提出了两个试点项目和一个培训方案。第一个试点项目是一个基础科学项目，将利用UTPA的专业知识合成多环芳香族化合物，并利用UTHSCSA的专业知识测试这些化合物作为抗癌剂。第二个试点项目旨在了解基因检测增加乳腺癌风险的态度和决策过程。第三个项目是UTPA学生在实验室工作，并了解癌症生物学的夏季本科课程，目的是增加来自德克萨斯州南部社区的学生对癌症研究感兴趣的人数。这种多层面的方法将加强对德克萨斯州边境沿着西班牙裔/拉丁裔人口的癌症研究和教育。

项目成果

Novel 6,12-disubstituted chrysene as potent anticancer agent: synthesis, in vitro and in vivo study.

新型 6,12-二取代屈作为有效的抗癌剂：合成、体外和体内研究。

• DOI: 10.1016/j.ejmech.2010.07.033
• 发表时间: 2010
• 期刊: European journal of medicinal chemistry
• 影响因子: 6.7
• 作者: Banik,BimalK;Becker,FrederickF
• 通讯作者: Becker,FrederickF

A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines.

微波辅助的硝酸二核培养基沿1,4-二氢吡啶的独特途径。

• DOI: 10.3390/molecules17032643
• 发表时间: 2012-03-05
• 期刊: Molecules (Basel, Switzerland)
• 作者: Bandyopadhyay D;Maldonado S;Banik BK
• 通讯作者: Banik BK

Uninsurance, underinsurance, and health care utilization in Mexico by US border residents.

• DOI: 10.1007/s10903-013-9828-2
• 发表时间: 2014-08
• 期刊: JOURNAL OF IMMIGRANT AND MINORITY HEALTH
• 影响因子: 1.9
• 作者: Su, Dejun;Pratt, William;Stimpson, Jim P.;Wong, Rebeca;Pagan, Jose A.
• 通讯作者: Pagan, Jose A.

Design, synthesis and biological evaluation of novel pyrenyl derivatives as anticancer agents.

作为抗癌剂的新型芘基衍生物的设计、合成和生物学评价。

• DOI: 10.1016/j.ejmech.2014.09.072
• 发表时间: 2015
• 期刊: European journal of medicinal chemistry
• 影响因子: 6.7
• 作者: Bandyopadhyay,Debasish;Sanchez,JorgeL;Guerrero,AdrianM;Chang,Fang-Mei;Granados,JoseC;Short,JohnD;Banik,BimalK
• 通讯作者: Banik,BimalK

An effective microwave-induced iodine-catalyzed method for the synthesis of quinoxalines via condensation of 1,2-diamines with 1,2-dicarbonyl compounds.

• DOI: 10.3390/molecules15064207
• 发表时间: 2010-06-09
• 期刊: Molecules (Basel, Switzerland)
• 作者: Bandyopadhyay D;Mukherjee S;Rodriguez RR;Banik BK
• 通讯作者: Banik BK