CLINICAL TRIAL: TESTOSTERONE DOSE RESPONSE IN SURGICALLY POSTMENOPAUSAL WOMEN

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 1.本研究的主要目的是在手术后睾酮浓度较低的绝经妇女中，建立一系列雄激素依赖结果的睾酮剂量-反应关系，包括性功能、脱脂质量、大腿肌肉力量和腿力、神经认知功能的几个领域、血浆脂质、载脂蛋白和脂蛋白颗粒以及胰岛素敏感性。 2.次要目标是确定与改善性、身体和神经认知功能有关的睾酮剂量和随后的血浆睾酮浓度的范围，这些剂量和浓度可以安全地用于妇女，而不会产生明显的不良影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 1. Primary objective of this study is to establish testosterone dose-response relationships in surgically menopausal women with low testosterone concentrations for a range of androgen-dependent outcomes, including sexual function, fat-free mass, thigh muscle strength and leg power, several domains of neurocognitive function, plasma lipids, apolipoproteins and lipoprotein particles, and insulin sensitivity. 2. The secondary objective is to determine the range of testosterone doses and subsequent plasma testosterone concentrations that are associated with improvements in sexual, physical and neurocognitive functions and that can be safely administered to women without significant adverse effects.