ADMINISTRATIVE CORE, OVERALL APPROACH

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 A.具体目标 梅哈里翻译研究中心的长期目标 (Metrc)是为临床和医疗服务建立国家模式 转化性健康差异研究。Metrc将发挥协同作用 Meharry正在进行的几项研究活动得到了以下支持 NCRR，包括少数民族机构研究中心，中心 S妇女健康中心艾滋病健康差距研究中心 研究、临床研究中心和临床研究 教育和职业发展计划。在基础上建设 Meharry的研究企业的特殊优势， Metrc的重点将是传染病，包括艾滋病毒/艾滋病， 和女性？S的健康。一个完整的翻译程序 将建立跨越基础、基础的研究 研究向应用型、参与型转变，涉及临床研究。短小的 学期目标是将容量和基础设施转变为 梅哈里的翻译研究。具体目标是：1. 发展行政基础设施，以促进 开发和维护一种集成和创新的 转化和临床研究计划(METRC)； 2.发展可持续发展的技术和支持基础设施 一项综合翻译和临床研究的计划； 3.建立促进协同互动的流程 以及RCTR教职员工之间的沟通需要 维持和发展创新临床和医疗服务的综合计划 翻译研究； 4.建立基础、转化和临床研究的渠道 这将维持和发展Metrc方案； 5.显著增强翻译和 建立新的参与者进行临床研究和临床 交互资源(PCIR)； 6.开展多学科培训和职业发展 临床和转化性研究计划 RCTR的基础设施、项目和师资优势； 7.参与并增强根据 Vanderbilt Meharry CTSA重点合作伙伴关系 以社区为基础的临床和医疗服务的流程和伙伴关系 翻译研究；以及 8.制定和实施短期自我评估计划 和RCTR的长期目标，包括执行和跟踪 计划活动。 A.1更改特定目标 当Meharry RCTR(METRC)赠款得到资助时，没有资金 被要求参加社区参与研究或 监管支持活动，因为这些活动已包括在 Meharry和Vanderbilt之间的重点CTSA合作伙伴关系。 不幸的是，来自这些组织的支持和参与程度 Meharry调查人员的CTSA活动一直较少 比预期的要好。确保取得进展，并确保这些 活动服务于Meharry临床和翻译的需求 研究人员，首席调查员已经修订了具体的 AIMS并制定了重新规划Metrc基金的计划 活动。修订后的具体目标是： Metrc社区参与研究核心 修订后的具体目标： 1.加强MMC调查人员对以下方面的知识 将社区纳入正在进行的研究项目。特定的 活动将包括说教讲座或研讨会。 2.增加社区参与研究的机会 通过Metrc试点赠款和合作研究赠款。 将针对社区参与者发放资助RFA 研究 3.促进内外社区参与的研究 通过Metrc赞助的联合研究会议进行合作， 杂志俱乐部和研讨会。 4.与Vanderbilt CTSA社区参与核心合作 促进CTSA资源的协作和利用 Meharry调查人员进行的社区参与研究。 Metrc监管知识和支持核心 修订后的目标： 1.开发一站式门户，支持翻译和 MMC研究人员的临床研究与基本功能有关 和行政服务(研究点，水星) 2.为调查员倡导者提供支持，他们将提供 向MMC调查人员提供专门和定向的协助 监管和合规管理任务，并作为 与IRB、其他监管机构和内部行政部门的联系 办公室(水星) 3.确保研究对象安全和知识，研究 诚信和质量，通过支持助理署长 监管知识和合规性 这些更改得到了Metrc IAC的批准，并被 于2011年4月15日提交给NCRR工作人员。克里斯汀·明加博士 特鲁宾将与希尔德雷思博士合作制定适当的修订 用于评估的记分卡。如上所述，将确定资金 并重新编程以支持这些活动，独立于 CTSA。值得注意的是，将继续尽一切努力确保 CTSA与范德比尔特在这些领域的伙伴关系是有意义的 为Meharry调查人员提供价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A. Specific Aims The longterm goal of the Meharry Translational Research Center (MeTRC) is to establish a national model for clinical and translational health disparities research. MeTRC will synergize several ongoing research initiatives at Meharry supported by NCRR, including Research Center in Minority Institutions, Center for AIDS Health Disparities Research, Center for Women¿s Health Research, Clinical Research Center, and Clinical Research Education and Career Development Program. Building on particular strengths of the research enterprise at Meharry, the focus of MeTRC will be on infectious disease, including HIV/AIDS, and women¿s health. An integrated program of translational research will be established that spans basic, fundamental research to applied, participantinvolved clinical studies. The short term goal is to transform the capacity and infrastructure for translational research at Meharry. The specific aims are: 1. Develop an administrative infrastructure that will facilitate development and maintenance of an integrated and innovative translational and clinical research program (MeTRC); 2. Develop a technical and support infrastructure that will sustain a program of integrated translational and clinical research; 3. Establish a process to facilitate the collaborative interactions and communication between RCTR faculty and staff needed to sustain and grow an integrated program of innovative clinical and translational research; 4. Establish a pipeline of basic, translational, and clinical research that will sustain and develop the MeTRC program; 5. Significantly enhance the infrastructure for translational and clinical research by establishing a new Participant and Clinical Interactions Resource (PCIR); 6. Develop a multidisciplinary training and careerdevelopment program in clinical and translational research that takes advantage of the infrastructure, programs, and faculty of RCTR; 7. Engage and enhance an existing program created under the VanderbiltMeharry CTSA Focused Partnership to facilitate processes and partnerships in communitybased clinical and translational research; and 8. Develop and implement a plan for selfevaluation of shortterm and longterm RCTR goals including implementation and tracking of program activities. A.1 Changes to Specific Aims When the Meharry RCTR (MeTRC) grant was funded, no funds were requested for the Community Engaged Research or Regulatory Support activities as these were included in the focused CTSA partnership between Meharry and Vanderbilt. Unfortunately, the level of support from, and involvement in these CTSA activities on the part of Meharry investigators has been less than anticipated. To insure that progress is made and that these activities serve the needs of Meharry clinical and translational researchers, the Principal Investigator has revised the specific aims and made plans to reprogram MeTRC funds for these activities. The revised specific aims: MeTRC Community Engagement Research Core Revised specific aims: 1. Enhance knowledge of MMC investigators regarding incorporating community into ongoing research projects. Specific activities would include didactic lectures or workshops. 2. Increase opportunities for community engaged research through MeTRC pilot grants and collaborative research grants. Funding RFAs will be issued targeted to community engaged research 3. Facilitate internal and external community engaged research collaborations through MeTRC-sponsored joint research meetings, journal clubs, and seminars. 4. Work with Vanderbilt CTSA Community Engagement Core to facilitate collaborations and utilization of CTSA resources for community engaged research by Meharry investigators. MeTRC Regulatory Knowledge and Support Core Revised aims: 1. Develop a one-stop portal for support of translational and clinical research by MMC investigators linked to essential functions and administrative services (Research Point, MeRCury) 2. Provide support for Investigator Advocates who will provide specialized and directed assistance to MMC investigators with regulatory and compliance administrative tasks and serve as liaisons to IRB, other regulatory bodies and internal administrative offices (MeRCury) 3. Ensure research subject safety and knowledge, research integrity, and quality by supporting an Assistant Director for Regulatory Knowledge and Compliance These changes were approved by the MeTRC IAC and were presented to NCRR staff on April 15, 2011. Dr. Christine Minja Trupin will work with Dr. Hildreth to develop appropriate revised scorecards for evaluation. As noted above funds will be identified and reprogrammed to support these activities independent of the CTSA. It is noted that every effort will continue to insure that the CTSA partnership with Vanderbilt in these areas is meaningful and provide value to Meharry investigators.