MH-GRID

MH网格

• 批准号: 8359900
• 负责人: Gary H Gibbons
• 金额: $ 4.16万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359900
• 关键词: Affect; African; African American; Behavioral Sciences; Bioethics; Bioinformatics; Cardiovascular system; Cataloging; Catalogs; Clinic; Clinical; Clinical Research; Clinics and Hospitals; Community Hospitals; Community Outreach; DNA; DNA Sequence; Databases; Desert Climate; Diet; Disease; Diuretics; Economic Factors; Electronic Health Record; Environmental Risk Factor; Epidemiology; Funding; Genetic; Genetic Databases; Genomics; Grant; Health; Health Personnel; Heart; Heart failure; Hylobates Genus; Hypertension; Incidence; Individual; Institution; Internet; Kidney Failure; Lead; Learning; Longitudinal Studies; Medicine; Methods; Minority; National Center for Research Resources; Other Genetics; Outcome; Patients; Population; Prevention; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resistance; Resources; Risk; Science; Scientist; Societies; Sodium; Source; Southeastern United States; Stroke; Technology; Translational Research; United States; United States National Institutes of Health; Universities; Variant; Virulent; Washington; college; cost; health disparity; minority health; patient population; prevent; safety net; social; therapy design; tool; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Individuals of African ancestry are likely to have DNA variants that favor sodium retention (and resistance to diuretic therapy) as a trait under positive selection in the historical context of a sodium-poor diet in an arid climate, that is now maladaptive in the context of high-sodium diets in industrialized societies. This project, which is the first of its kind to focus primarily on minority patients, will build a database of genetic and other health information from minority populations by bringing together a collaborating web of institutions, hospitals and community clinics that will share information derived from electronic health records. The effort will begin in the Southeast, known to have the highest incidence of high blood pressure and stroke among African-Americans. The initial objective is to use this database to learn more about why minority patients suffer a more virulent clinical course of hypertension and its complications, such as stroke. Investigators plan to extend these studies to other conditions that disproportionally affect African-Americans. The database will allow long term study and short term action in finding new, more effective methods of treatment and prevention. It will also allow scientists and health care workers to delve more deeply into the genetic, social and economic factors connected to this disease and overall health. The long-term objective of the Minority Health GRID project is to develop more sophisticated approaches to 'personalized medicine' that are applicable across the diverse spectrum of patient populations in the United States. The MH-GRID intends to develop predictive tools that will allow clinicians to identify at-risk patients with hypertension who are most likely to benefit from interventions designed to prevent complications such as stroke, heart failure or kidney failure. The project is among the first in the nation with a specific focus on applying state-of-the-art technology and multi-level approaches that will facilitate the ability of the clinician to capture genetic, social and environmental factors that influence the course of disease. Dr. Gibbons will lead an outstanding multi-disciplinary team of scientists with expertise in health disparities research, genomic science, bioinformatics, bioethics, epidemiology, minority community outreach, behavioral science and cardiovascular medicine. Although the Minority Health GRID has an initial focus on tracking health outcomes at safety-net clinics and hospitals in the Southeastern United States, the team includes a variety of collaborative institutions such as  the National Institutes of Health, Emory University, University of Washington, Jackson State University, Baylor College of Medicine, the Jackson Heart Study, Jackson-Hinds Clinic and Stanford University. The study will use the latest DNA sequencing technology to create one of the largest existing 'catalogues' of detailed DNA sequence information of African-American patients.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 非洲血统的个体很可能具有有利于钠潴留（和对利尿剂治疗的抵抗）的DNA变异，这是在干旱气候中钠缺乏饮食的历史背景下的积极选择下的一种特征，现在在工业化社会的高钠饮食背景下是不适应的。 这是第一个主要侧重于少数群体病人的项目，它将建立一个少数群体人口遗传和其他健康信息数据库，办法是将各机构、医院和社区诊所的协作网络汇集在一起，分享从电子健康记录中获得的信息。 这项工作将开始在东南部，已知有最高的发病率高血压和中风的非洲裔美国人。 最初的目标是使用这个数据库来更多地了解为什么少数民族患者遭受更致命的高血压及其并发症，如中风的临床过程。 研究人员计划将这些研究扩展到其他影响非裔美国人健康的疾病。 该数据库将允许长期研究和短期行动，以寻找新的，更有效的治疗和预防方法。 它还将使科学家和卫生保健工作者能够更深入地研究与这种疾病和整体健康有关的遗传、社会和经济因素。 少数民族健康GRID项目的长期目标是开发更复杂的方法来“个性化医疗”，适用于美国不同的患者人群。MH-GRID旨在开发预测工具，使临床医生能够识别最有可能从旨在预防中风、心力衰竭或肾衰竭等并发症的干预措施中获益的高血压高危患者。该项目是全国首批重点应用最先进技术和多层次方法的项目之一，这些技术和方法将促进临床医生捕捉影响疾病进程的遗传、社会和环境因素的能力。 博士吉本斯将领导一个杰出的多学科科学家团队，他们在健康差异研究、基因组科学、生物信息学、生物伦理学、流行病学、少数民族社区外展、行为科学和心血管医学方面具有专业知识。 虽然少数民族健康网格最初的重点是跟踪美国东南部安全网诊所和医院的健康结果，但该团队包括各种合作机构，如  美国国立卫生研究院、埃默里大学、华盛顿大学、杰克逊州立大学、贝勒医学院、杰克逊心脏研究、杰克逊-海因兹诊所和斯坦福大学。该研究将使用最新的DNA测序技术，创建非洲裔美国人患者详细DNA序列信息的现有最大“目录”之一。