Southwestern Comprehensive Sickle Cell Center

西南综合镰状细胞中心

• 批准号: 7880650
• 负责人: GEORGE R BUCHANAN
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-14 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7880650
• 关键词: Southwestern; Comprehensive; Sickle; Cell; Center

DESCRIPTION (provided by applicant): The Southwestern Comprehensive Sickle Cell Center (the "Center"), which has served as one of the ten NHLBI-funded Centers during 2003-2008 grant cycle, is applying for continued support during the next funding cycle. The Center, based at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) and Children's Medical Center Dallas (CMCD), will continue to include other collaborating medical centers whose physicians and other personnel are dedicated to the care of persons with sickle cell disease and the conduct of novel clinical, translational, and health services research. These other Centers are the University of Texas at Dallas, the University of Oklahoma Health Sciences Center, the University of Texas Medical Branch at Galveston, and the University of Florida College of Medicine. The Center's track record during the current grant period in the CSCC Clinical Trials Consortium has been exemplary. Center investigators lead two of the five national clinical trials opened thus far and play prominent roles on Consortium committees. Moreover, clinical trial enrollment from the multiple sites in our Center has been substantial. The Center currently ranks second overall among the ten comprehensive centers in patient enrollment. The Center is also successfully executing basic science, clinical intra-Center, and a variety of other collaborative and institutional research protocols, accompanied by smoothly functioning administrative and patient services cores. The Center plans to continue and appreciably expand myriad research, patient care, education, and advocacy initiatives during the next five years. A cohesive, interactive, and collaborative spirit exists among Center investigators and their institutions, thus assuring the Southwestern Comprehensive Sickle Cell Center's continued success.

描述（由申请人提供）： 西南综合镰状细胞中心（“中心”）是2003-2008年赠款周期内由NHLBI资助的10个中心之一，目前正在申请下一个供资周期的继续支助。该中心，总部设在得克萨斯大学西南医学中心在达拉斯（UT西南）和儿童医学中心达拉斯（CMCD），将继续包括其他合作医疗中心，其医生和其他人员致力于与镰状细胞疾病的人的护理和新的临床，转化和卫生服务研究的行为。这些其他中心是德克萨斯大学达拉斯分校、俄克拉荷马州大学健康科学中心、德克萨斯大学医学分支加尔维斯顿分校和佛罗里达大学医学院。该中心在CSCC临床试验联盟当前资助期间的跟踪记录堪称典范。迄今为止，中心研究人员领导了五项国家临床试验中的两项，并在联盟委员会中发挥了重要作用。此外，我们中心的多个研究中心的临床试验入组人数非常多。该中心目前在10个综合性中心的患者招募中排名第二。该中心还成功地执行基础科学，临床中心内，以及各种其他合作和机构研究协议，伴随着顺利运作的行政和患者服务核心。该中心计划在未来五年内继续并明显扩大无数的研究，病人护理，教育和宣传活动。中心研究人员及其机构之间存在着一种凝聚力、互动性和协作精神，从而确保了西南综合镰状细胞中心的持续成功。

项目成果

Ubiquitination of erythrocyte spectrin regulates the dissociation of the spectrin-adducin-f-actin ternary complex in vitro.

红细胞血影蛋白的泛素化在体外调节血影蛋白-内收蛋白-f-肌动蛋白三元复合物的解离。

• 发表时间: 2004
• 期刊: Cellular and molecular biology (Noisy-le-Grand, France)
• 作者: Mishra,R;Goodman,SR
• 通讯作者: Goodman,SR

Bordetella holmesii bacteremia in sickle cell disease.

• DOI: 10.1002/pbc.21712
• 发表时间: 2008-12
• 期刊: Pediatric blood & cancer
• 影响因子: 3.2
• 作者: McCavit TL;Grube S;Revell P;Quinn CT
• 通讯作者: Quinn CT

Ubiquitination of spectrin regulates the erythrocyte spectrin-protein-4.1-actin ternary complex dissociation: implications for the sickle cell membrane skeleton.

血影蛋白泛素化调节红细胞血影蛋白-蛋白-4.1-肌动蛋白三元复合物解离：对镰状细胞膜骨架的影响。

• 发表时间: 2004
• 期刊: Cellular and molecular biology (Noisy-le-Grand, France)
• 作者: Ghatpande,SS;Goodman,SR
• 通讯作者: Goodman,SR

Prevalence of intracardiac shunting in children with sickle cell disease and stroke.

• DOI: 10.1016/j.jpeds.2009.10.012
• 发表时间: 2010-04
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Dowling, Michael M.;Lee, Nancy;Quinn, Charles T.;Rogers, Zora R.;Boger, Deborah;Ahmad, Naveed;Ramaciotti, Claudio;Buchanan, George R.
• 通讯作者: Buchanan, George R.

Spectrin and ubiquitination: a review.

血影蛋白和泛素化：综述。

• 发表时间: 2005
• 期刊: Cellular and molecular biology (Noisy-le-Grand, France)
• 作者: Hsu,Y-J;Goodman,SR
• 通讯作者: Goodman,SR