Pediatric Hematology and Oncology Research

描述（由申请人提供）：本竞争性续期申请的目的是为达拉斯德克萨斯大学西南医学中心儿科的四名儿科血液肿瘤学研究员（两名二年级和两名三年级）提供持续的国家服务研究奖支持。这些奖金将用于支持年轻儿科医生的研究培训，他们已经完成了临床奖学金年，致力于患者诊断和管理，并接触到研究方法。德克萨斯大学西南分校的儿科血液学肿瘤学奖学金项目是在20世纪80年代中期发展起来的，其广泛目标是培训致力于学术领域全职职业的医生，鉴于全国儿科血液学肿瘤学临床和实验室学者的持续短缺，这是一个至关重要的需求。该奖学金培训项目在西南大学的持续成功是有保证的，因为：(2)在癌症治疗、分子肿瘤学、癌症生存、镰状细胞病、出血性和血栓性疾病、肿瘤支持治疗和癌症遗传学等领域的卓越临床和实验室研究记录；(3)与杰出基础科学研究者的良好合作和承诺；(4)现有的基础设施和以患者为导向的研究的主要新机构举措。这些特点结合在一起，为申请津贴支持的研究员提供了一个良好的前沿研究培训环境。目前和以前的儿科血液肿瘤学学员在不同研究领域的研究人员的指导下工作。自1990年首次颁发奖项以来，31名受训者获得了机构NRSA的支持，其中大多数已成功地成为临床或实验室调查员或继续成为研究员。德克萨斯大学西南分校的儿童血液肿瘤学部门及其多个合作实验室和临床研究领域的刺激智力参与将继续为学员成为独立研究者提供必要的丰富环境。

DESCRIPTION (provided by applicant): The purpose of this competitive renewal application is to request continued National Service Research Award support for four pediatric hematology-oncology fellows annually (two second-year and two third-year) in the Department of Pediatrics at The University of Texas Southwestern Medical Center at Dallas (UT Southwestern). These awards will be used to support research training of young pediatricians who have completed a clinical fellowship year devoted to patient diagnosis and management and exposure to research methods. The pediatric hematology-oncology fellowship program at UT Southwestern was developed in the mid-1980's with the broad aim of training physicians committed to full-time careers in the academic arena, a vital need in view of the continued national shortage of clinical and laboratory scholars in pediatric hematology-oncology. The continued success of this fellowship training program at UT Southwestern is assured, given: (1) a large, diverse, and readily accessible patient population, (2) a track record of clinical and laboratory investigative excellence in areas such as cancer therapeutics, molecular oncology, cancer survivorship, sickle cell disease, hemorrhagic and thrombotic disorders, oncologic supportive care, and cancer genetics, (3) well functioning collaborations with and commitment from outstanding basic science investigators, and (4) existing infrastructure and major new institutional initiatives on patient-oriented research. These features combined provide an excellent environment for cutting-edge research training of fellows supported by the requested stipends. Current and former pediatric hematology-oncology trainees have worked under the preceptorship of investigators in diverse research areas. Since the initial award in 1990, thirty-one trainees have received institutional NRSA support and most have been successful as clinical or laboratory investigators or continue as fellows. The stimulating intellectual involvement in the Division of Pediatric Hematology-Oncology and its multiple collaborating laboratories and clinical research domains at UT Southwestern will continue to provide the rich milieu necessary for trainees to become independent investigators.