Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序融入临床医学
基本信息
- 批准号:8236471
- 负责人:
- 金额:$ 241.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-12-05 至 2015-11-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAlgorithmsAttitudeBehaviorBehavioralCategoriesClinicalClinical MedicineClinical TrialsCollaborationsConsentDataDisclosureDiseaseDisease modelElectronicsEnrollmentFamilial Hypertrophic CardiomyopathyFamilyFutureGenesGenetic VariationGenetic screening methodGenomicsHealthHealth Care CostsHuman GeneticsHypertrophic CardiomyopathyIndividualLaboratoriesMedicalMedicineMethodsModelingMonitorMotivationOutcomePatient CarePatientsPhysiciansPreventionPrimary Care PhysicianProcessProtocols documentationPsychological ImpactRandomizedRandomized Clinical TrialsRecording of previous eventsRecruitment ActivityReportingResearchRiskSafetySequence AnalysisSymptomsTest ResultTestingUpdateVariantarmbaseclinical careclinical practiceclinically relevantexperiencegenome sequencinghealth economicsinsightmiddle agenovelpreferenceresponsestandard of care
项目摘要
DESCRIPTION (provided by applicant): In this highly collaborative multi-disciplinary initiative, we propose to explore and compare the impact of using WGS in clinical conditions that model pure forms of each of these approaches. To model General Genomic Medicine, 10 primary care physicians and 100 of their healthy middle-aged patients will be enrolled. To model Disease-Specific Genomic Medicine, 10 cardiologists and 100 of their patients presenting with familial hypertrophic cardiomyopathy (HCM) will be enrolled. We will conduct an exploratory clinical trial randomizing physicians and their patients within each of these models to receive clinically meaningful information derived from WGS versus current standard of care. Project 1 will create standards for variant disclosure, enroll physicians and patients into the protocol and safely monitor the use of genomic information in clinical practice. Project 2 will sequence, analyze and interpret WGS for the physicians to use. And Project 3 will examine preferences and motivations of physicians and patients enrolled, evaluate the flow and utilization of genomic information within the clinical interactions, and assess understanding, behavior, medical consequences and healthcare costs associated with the use of WGS in these models of medical practice. This initiative will significantly accelerate the use of genomics into clinical medicine by creating and
safely testing novel ways of integrating information from WGS into physician care of patients.
PUBLIC HEALTH RELEVANCE: Physicians will soon use WGS to derive insight into future health risks and inform prevention efforts in healthy patients and to interrogate particular sets o genes known to be associated with disease in patients presenting with a family history and symptoms. The results of this study will accelerate the use of genomics in clinical medicine by creating and testing ways to integrate WGS into physician care of patients.
描述(由申请人提供):在这个高度协作的多学科计划中,我们建议探索和比较在模拟这些方法的纯形式的临床条件中使用WGS的影响。为了模拟普通基因组医学,将招募10名初级保健医生和100名健康的中年患者。为了模拟疾病特异性基因组医学,将招募10名心脏病专家和100名家族性肥厚型心肌病(HCM)患者。 我们将进行一项探索性临床试验,在这些模型中随机分配医生及其患者,以获得来自WGS与当前标准治疗的有临床意义的信息。 项目1将为变异披露制定标准,将医生和患者纳入方案,并安全地监测基因组信息在临床实践中的使用。项目2将对WGS进行测序、分析和解释,供医生使用。项目3将检查医生和患者的偏好和动机,评估临床相互作用中基因组信息的流动和利用,并评估在这些医疗实践模式中使用WGS相关的理解,行为,医疗后果和医疗成本。 这一举措将大大加快基因组学在临床医学中的应用,
安全地测试将来自WGS的信息整合到患者的医生护理中的新方法。
公共卫生相关性:医生很快将使用WGS来深入了解未来的健康风险,并为健康患者的预防工作提供信息,并询问已知与有家族史和症状的患者的疾病相关的特定基因组。这项研究的结果将加速基因组学在临床医学中的应用,通过创建和测试将WGS整合到患者的医生护理中的方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert C. Green其他文献
Neighborhood topologies in central force optimization
- DOI:
10.1109/ssci.2017.8285384 - 发表时间:
2017-11 - 期刊:
- 影响因子:0
- 作者:
Robert C. Green - 通讯作者:
Robert C. Green
Family genetic risk communication and reverse cascade testing in the BabySeq project
婴儿序列项目中的家庭遗传风险沟通和反向级联测试
- DOI:
10.1016/j.gim.2024.101350 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:6.200
- 作者:
Melissa K. Uveges;Hadley Stevens Smith;Stacey Pereira;Casie Genetti;Amy L. McGuire;Alan H. Beggs;Robert C. Green;Ingrid A. Holm;Pankaj B. Agrawal;Alan H. Beggs;Wendi N. Betting;Ozge Ceyhan-Birsoy;Kurt D. Christensen;Dmitry Dukhovny;Shawn Fayer;Leslie A. Frankel;Casie A. Genetti;Chet Graham;Robert C. Green;Amanda M. Gutierrez;Bethany Zettler - 通讯作者:
Bethany Zettler
Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics
通过全外显子组测序结合神经影像遗传学鉴定功能变异
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:11
- 作者:
K. Nho;Jason J. Corneveaux;Sungeun Kim;Hai Lin;S. Risacher;L. Shen;S. Swaminathan;V. Ramanan;Yunlong Liu;T. Foroud;M. Inlow;A. Siniard;Rebecca Reiman;P. Aisen;Ronald C. Petersen;Robert C. Green;C. Jack;Michael W. Weiner;C. Baldwin;K. Lunetta;Lindsay A. Farrer;S. Furney;Simon Lovestone;Andrew Simmons;Patrizia Mecocci;Bruno Vellas;Magda Tsolaki;I. Kloszewska;H. Soininen;B. McDonald;M. Farlow;B. Ghetti;M. Huentelman;A. Saykin - 通讯作者:
A. Saykin
Liste de contrôle de l’Association canadienne des médecins d’urgence concernant le traitement de la sepsie: optimisation de la prise en charge de la sepsie au sein des services des urgences canadiens
加拿大脓毒症紧急医疗协会控制清单:加拿大脓毒症紧急服务奖的优化
- DOI:
10.2310/8000.2011.110610f - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Dennis Djogovic;Robert C. Green;R. Keyes;Sara Gray;Robert Stenstrom;David Sweet;Jonathan S. Davidow;Edward Patterson;D. Easton;Shavaun MacDonald;Jonathan Gaudet;Michael R. Kolber;David Lechelt;D. Howes - 通讯作者:
D. Howes
Genetic counselors’ perspectives on genomic screening of apparently healthy newborns in the United States
- DOI:
10.1016/j.gimo.2024.101885 - 发表时间:
2024-01-01 - 期刊:
- 影响因子:
- 作者:
Maya C. del Rosario;Kathleen B. Swenson;Stephanie Coury;Jennifer Schwab;Robert C. Green;Nina B. Gold - 通讯作者:
Nina B. Gold
Robert C. Green的其他文献
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{{ truncateString('Robert C. Green', 18)}}的其他基金
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
在不同健康婴儿群体中实施全基因组测序筛查
- 批准号:
10652609 - 财政年份:2021
- 资助金额:
$ 241.08万 - 项目类别:
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
在不同健康婴儿群体中实施全基因组测序筛查
- 批准号:
10442366 - 财政年份:2021
- 资助金额:
$ 241.08万 - 项目类别:
Experiences and Outcomes in Early Adopters of Predispositional Sequencing
倾向性测序早期采用者的经验和成果
- 批准号:
9789918 - 财政年份:2018
- 资助金额:
$ 241.08万 - 项目类别:
Experiences and Outcomes in Early Adopters of Predispositional Sequencing
倾向性测序早期采用者的经验和成果
- 批准号:
9980970 - 财政年份:2018
- 资助金额:
$ 241.08万 - 项目类别:
Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals
公开淀粉样蛋白成像结果对认知正常个体的影响
- 批准号:
9518218 - 财政年份:2015
- 资助金额:
$ 241.08万 - 项目类别:
Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序融入临床医学
- 批准号:
8914756 - 财政年份:2011
- 资助金额:
$ 241.08万 - 项目类别:
Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序与临床医学的整合
- 批准号:
8826154 - 财政年份:2011
- 资助金额:
$ 241.08万 - 项目类别:
Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序融入临床医学
- 批准号:
9173270 - 财政年份:2011
- 资助金额:
$ 241.08万 - 项目类别:
Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序融入临床医学
- 批准号:
8914780 - 财政年份:2011
- 资助金额:
$ 241.08万 - 项目类别:
Integration of Whole Genome Sequencing into Clinical Medicine
全基因组测序与临床医学的整合
- 批准号:
8586322 - 财政年份:2011
- 资助金额:
$ 241.08万 - 项目类别:
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