CB: Tissue Core

核心：样本 亚利桑那大学和罗切斯特大学的联合组织资源中心将拥有 负责收集、储存和编目来自患有 淋巴组织增生性疾病，在亚利桑那州和詹姆斯P威尔莫特癌症中心， 亚利桑那大学和罗切斯特大学。此外，酷睿还将正常采集和存储 淋巴组织、血液和骨髓细胞用作生物学研究的对照， 对应的恶性组织标本储存为速冻块、石蜡块、活细胞 悬浮液和冷冻血清等分试样。组织采购和数据收集是在 IRB批准的方案。所有患者都必须在知情同意书上签字， 使用严格保持患者匿名的程序提取临床或流行病学信息， 这符合健康保险可携带性和责任法案（HIPAA）制定的指导方针。 此外，在亚利桑那大学，未经同意的患者多余的诊断组织被作为常规储存 实践未经IRB直接批准和豁免，不得提取这些患者的临床信息， 知情同意。然而，这些组织更频繁，并为测试提供有价值的样本 发展和可行性研究。血淋巴细胞系的库也保持有活性。 收集感兴趣的新细胞系。这些设施已经相互整合， 样本分发和软件开发。组织资源核心的总体目标是提供 必要的患者样本和细胞系，以支持淋巴瘤孢子转化研究项目。 具体目标是： 1.根据以下法规指南同意、采集、储存和注释高质量样本： 以最大限度地发挥其潜在效用; 2.通过病理学评价、免疫表型分析、分子研究和 临床特征; 3.通过仔细的库存控制，组织微阵列的创建， DNA和RNA; 4.以及时有效的方式分发样品，以最大限度地发挥其转化研究潜力。 亚利桑那大学和罗切斯特大学的这些综合资源将与每一个 在此SPORE拨款申请中提出的项目，并将促进合作的发展 项目内外都有。

COREB: SPECIMEN The combined Tissue Resource Core at the Universities of Arizona and Rochester will have the responsibility of collecting, storing and cataloging pathological specimens from patients with lymphoproliferative disorders that are seen at the Arizona and James P Wilmot Cancer Centers at the Universities of Arizona and Rochester respectively. In addition, the Core will also collect and store normal lymphoid tissue and blood and bone marrow cells to be used as controls for biologic studies that use the corresponding malignant tissue. Specimens are stored as snap frozen blocks, paraffin blocks, viable cell suspensions, and frozen serum aliquots. Tissue procurement and data collection is done under the auspices of IRB approved protocols at each institution. All patients are required to sign an informed consent before abstracting clinical or epidemiologic information using procedures that maintain strict patient anonymity and that adhere to the guidelines established by the Health Insurance Portability and Accountability Act (HIPAA). In addition, at U of A, excess diagnostic tissue from non-consented patients is stored as a matter of routine practice. No clinical information is abstracted on these patients without direct IRB approval and waiver of informed consent. However, these tissues are more frequent and make valuable samples for test development and feasibility studies. A bank of hematolymphoid cell lines is also maintained with active collection of new cell lines of interest. These facilities are already integrated with each other regarding sample distribution and software development. The overall goal of the Tissue Resource Core is to provide necessary patient samples and cell lines to support the Lymphoma SPORE translational research projects. The specific aims are: 1. To consent, collect, store, and annotate high quality samples in accordance with regulatory guidelines in order to maximize their potential usefulness; 2. To characterize samples through pathologic evaluation, immunophenotyping, molecular studies, and clinical features; 3. To conserve tissues through careful inventory control, creation of tissue microarrays, up-front extraction of DMA and RNA; 4. To distribute samples in a timely and efficient manner to maximize their translational research potential. These combined resources at the University of Arizona and Rochester will be intimately involved with each of the projects proposed in this SPORE grant application and will facilitate the development of collaborative projects within and beyond the SPORE.