Structure/function of P2X receptors: ion access pathway and selectivity mechanism

P2X受体的结构/功能：离子进入途径和选择性机制

• 批准号: 8298368
• 负责人: Toshimitsu Kawate
• 金额: $ 24.9万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298368
• 关键词: Action Potentials; Affect; Anions; Architecture; Binding; Binding Sites; Calcium; Cardiovascular system; Cations; Charge; Chimera organism; Data; Disease; Electrostatics; Esthesia; Foundations; Gated Ion Channel; Goals; Human body; Inflammation; Inflammatory; Inflammatory Response; Instruction; Intervention; Ion Channel; Ions; Knowledge; Lateral; Lead; Ligand Binding; Measures; Mediating; Membrane; Molecular; Mutate; Nervous system structure; P2X-receptor; Pain; Pathway interactions; Pharmacology; Physiological; Play; Rattus; Receptor Activation; Research; Role; Sensory; Signal Transduction; Structure; Surface; System; Techniques; X-Ray Crystallography; base; channel blockers; design; extracellular; inflammatory pain; insight; mutant; novel; novel therapeutics; patch clamp; purinoceptor P2X5; receptor; receptor function; small molecule; transmission process