Structure/function of P2X receptors: ion access pathway and selectivity mechanism
Structure/function of P2X receptors: ion access pathway and selectivity mechanism
批准号:
8298368
负责人:
Toshimitsu Kawate
金额:
$24.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2014-08-31
关键词:
Action PotentialsAffectAnionsArchitectureBindingBinding SitesCalciumCardiovascular systemCationsChargeChimera organismDataDiseaseElectrostaticsEsthesiaFoundationsGated Ion ChannelGoalsHuman bodyInflammationInflammatoryInflammatory ResponseInstructionInterventionIon ChannelIonsKnowledgeLateralLeadLigand BindingMeasuresMediatingMembraneMolecularMutateNervous system structureP2X-receptorPainPathway interactionsPharmacologyPhysiologicalPlayRattusReceptor ActivationResearchRoleSensorySignal TransductionStructureSurfaceSystemTechniquesX-Ray Crystallographybasechannel blockersdesignextracellularinflammatory paininsightmutantnovelnovel therapeuticspatch clamppurinoceptor P2X5receptorreceptor functionsmall moleculetransmission process
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会议论文
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资助金额:$24.64万
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依托单位:
海外基金