The Distinct Role of CBP and p300 in Regulating Hepatic Glucose Production
The Distinct Role of CBP and p300 in Regulating Hepatic Glucose Production
批准号:
8310339
负责人:
Ling He
金额:
$24.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2014-08-31
关键词:
AcetylationAdultAffectAnimalsAntidiabetic DrugsAwardBindingBloodBlood GlucoseCREB1 geneCell LineCellsComplexCyclic AMPCyclic AMP-Dependent Protein KinasesDataDevelopmentDiabetes MellitusDietDirect CostsEP300 geneEnzyme GeneEnzymesExhibitsFacilities and Administrative CostsFastingFatty acid glycerol estersForskolinGene ExpressionGene Expression ProfileGenesGlucagonGluconeogenesisGlucoseGoalsHealthHepaticHepatocyteHyperglycemiaIndividualInsulinInsulin ResistanceKnockout MiceLiverMediatingMediator of activation proteinMentorsMetforminModalityMorbidity - disease rateMusMutant Strains MiceMutationNewly DiagnosedNon-Insulin-Dependent Diabetes MellitusOkadaic AcidPancreasPatientsPhasePhenotypePhosphorylationPhosphorylation SitePhosphotransferasesPhysiologicalPrevalenceProtein DephosphorylationProtein phosphataseRegulationRelative (related person)RoleSerineSignal PathwaySiteSocietiesTestingTranscriptional RegulationUnited StatesUp-Regulationcalyculin Afeedingglucose productionhepatic gluconeogenesishepatoma cellinsulin signalinglipid biosynthesismortalitymutant mouse modelprogramsreconstitutionsmall hairpin RNA
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海外基金