Klotho Regulation and Aging

Klotho 调节和衰老

• 批准号: 8223859
• 负责人: Gwendalyn DiAnn King
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223859
• 关键词: 3' Untranslated Regions; Accounting; Affect; Age; Age-Months; Aging; Aging-Related Process; Animals; Atherosclerosis; Atrophic condition of skin; Binding; Binding Sites; Bone Density; Brain; Brain Injuries; Brain Part; Cell physiology; Cells; Cessation of life; Deterioration; Development; Disease; Down-Regulation; Elements; Gene Expression; Gene Expression Regulation; Genes; Genetic Transcription; Genetic Translation; Guanine + Cytosine Composition; Hair; Human; Impaired cognition; Impairment; In Vitro; Infertility; Knowledge; Lead; Life; Light; Longevity; Macaca mulatta; Metabolism; MicroRNAs; Modeling; Molecular; Mus; Mutant Strains Mice; Neurodegenerative Disorders; Neurons; Normal Cell; Organ; Osteoporosis; Oxidative Stress; Pathway interactions; Phenotype; Population; Predisposition; Process; Proteins; Pulmonary Emphysema; Rattus; Reactive Oxygen Species; Regulation; Resistance; Rodent; Role; SP1 gene; Sampling; Signal Pathway; Time; Transcription Initiation; Transgenic Mice; Translations; Work; abstracting; age effect; age group; age related; aged; aging brain; aging gene; aging population; anti aging; biological adaptation to stress; calcification; klotho protein; long term memory; mRNA Stability; memory retention; nonhuman primate; normal aging; novel; overexpression; oxidation; oxidative damage; pathological aging; prevent; promoter; response; therapeutic development; transcription factor