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Coordinating Translesion DNA Synthesis Opposite Damaged DNA

Coordinating Translesion DNA Synthesis Opposite Damaged DNA
协调跨损伤 DNA 合成与受损 DNA 相对
批准号：
8206324
负责人：
ROBERT L EOFF
金额：
$24.9万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-07-01 至 2013-12-31
来源：
https://reporter.nih.gov/project-details/8206324
关键词：
AddressAffectAffinityAgeAgingAging-Related ProcessArchaeaAttentionBase Excision RepairsBase PairingBindingBiochemicalBiochemistryBiologic CharacteristicBiologicalBiological AssayBypassCell Culture TechniquesCell CycleCell DeathCell LineCell Stress ProcessCell divisionCellsChemicalsChromosome Fragile SitesCodeColorectal NeoplasmsComplexCrystallographyDNADNA AdductsDNA DamageDNA FingerprintingDNA Modification ProcessDNA StructureDNA biosynthesisDNA lesionDNA-Directed DNA PolymeraseDeuteriumDevelopmentDiseaseDown-RegulationEnhancersEnzymesEpigenetic ProcessEquilibriumEventEvolutionExposure toFamilyFamily memberFunctional disorderFundingFutureG-QuartetsG2 PhaseGeneticGenetic CodeGenetic EpistasisGenetic MaterialsGenomeGenomic InstabilityGenomicsGerm-Line MutationGlioblastomaGliomaGoalsHumanHydrogenImmunoglobulin Somatic HypermutationImmunoprecipitationIn VitroIncidenceIndividualInstructionIonizing radiationKineticsLeadLengthLesionLifeLinkMaintenanceMalignant NeoplasmsMammary NeoplasmsMass Spectrum AnalysisMediatingMethodsMindModificationMolecularMolecular StructureMutagenesisMutagensMutationNucleotidesOrganismOutcomeOxidative StressParaffin EmbeddingPathologistPathologyPathway interactionsPatientsPersonal SatisfactionPhasePhenotypePhosphodiesterase IPhosphorylationPlayPoisonPolymerasePost-Translational Protein ProcessingPremature aging syndromeProcessProkaryotic CellsPropertyProteinsProteomicsRegulationRegulatory ElementResearchResolutionRoleS PhaseSignal PathwaySiteSkin CancerSlideSourceStagingStressStructureSubstrate SpecificitySystemTestingThinkingTissuesTumor BiologyUV induced DNA damageUbiquitinationWerner SyndromeX-Ray Crystallographybasecancer therapycarcinogenesisdesignearly onsethelicasehuman WRN proteinimprovedin vitro Assayin vivoinsightlaser capture microdissectionloss of function mutationmalignant breast neoplasmmembermolecular assembly/self assemblymolecular dynamicsneoplastic cellnormal agingnucleotide metabolismpreventprognostic indicatorprotein protein interactionrepairedreplication factor Aresearch studyresponsescaffoldsingle moleculestructural biologytumortumor progressionultraviolet irradiation

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