Mechanisms of Spliceosome Assembly and Splice Site Selection

剪接体组装和剪接位点选择的机制

• 批准号: 8308082
• 负责人: Aaron Andrew Hoskins
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308082
• 关键词: 3' Splice Site; 5' Splice Site; ATP Hydrolysis; ATP phosphohydrolase; Achievement; Address; Affect; Affinity; Alternative Splicing; Award; Base Pairing; Binding; Binding Proteins; Biochemical; Biological Assay; Biological Models; Biology; Boxing; Cell Extracts; Cells; Chemicals; Chemistry; Collaborations; Complex; Coupling; Custom; Cystic Fibrosis; Disease; Dissection; Dissociation; Distal; Ensure; Enzymes; Event; Exons; Fluorescence; Funding; Gene Expression Regulation; Genetic; Goals; Growth; Health; Hela Cells; Human; Human Biology; Individual; Instruction; Introns; Kinetics; Laboratories; Length; Ligation; Location; Malignant Neoplasms; Measurement; Medicine; Messenger RNA; Methodology; Methods; Molecular Conformation; Mutagenesis; Mutation; Nuclear Extract; Organism; Pathway interactions; Phase; Plasmids; Play; Positioning Attribute; Probability; Process; Production; Protein Binding; Protein Conformation; Protein Isoforms; Proteins; Publications; RNA; RNA Cap-Binding Proteins; RNA Caps; RNA Processing; RNA Splicing; Reaction; Reading Frames; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resistance; Retinitis Pigmentosa; Role; Saccharomyces cerevisiae; Scheme; Science; Signal Transduction; Site; Small Nuclear RNA; Small Nuclear Ribonucleoproteins; Spectrum Analysis; Spliceosome Assembly Pathway; Spliceosomes; Staging; Structure; Surface; System; Thermodynamics; Transcript; U1 Small Nuclear Ribonucleoprotein; U1 small nuclear RNA; U2 Small Nuclear Ribonucleoprotein; U2 small nuclear RNA; Work; Yeast Model System; Yeasts; base; college; fluorescence microscope; fluorophore; genetic regulatory protein; human disease; improved; insight; interest; mRNA Precursor; mutant; prevent; programs; protein function; protein protein interaction; research study; single molecule; single-molecule FRET; stem; success; tool