Women's Cancers

女性癌症计划区由19名成员组成，横跨加州大学洛杉矶分校内的7个部门。在……里面 在过去的竞争周期中，该项目的研究人员撰写了199篇论文，其中39篇(20%)是 方案间和27(14%)方案内。60篇(30%)发表在高影响力的期刊上。10 该计划领域的成员使用了JCCC目前资助的8个共享资源中的5个。 在本供资年度，同行审查供资总额为1220万美元，其中包括240万美元 来自国家癌症研究所的100万美元。与其他计划领域一样，JCCC培养了许多互动的 支持妇女癌症方案研究人员的活动和许多共享资源 区域。在本赠款周期内，JCCC以CCSG发展基金的形式提供资金， 向GR计划领域提供的机构支持和慈善捐赠总额为991,008美元。这些资金得到了支持 跨学科助学金，种子助学金，招聘/保留，计划领域领导支持，资助 新兴共享资源和受训人员的使用。计划区成员中有九人是 JCCC支持。 妇女癌症计划寻求解决以下问题的研究、临床和教育活动 女性中的恶性肿瘤。该计划促进了两人之间的互动和合作活动 成员，以便在乳房和妇女生殖领域开展多学科研究 癌症。它对临床癌症研究采取了全面的方法，重点是转译研究。 妇女癌症方案的目标是：1)建立基于遗传的风险评估和咨询 通过了解高危/遗传易感性；2)评估和实施预防和筛查 通过了解高危/遗传易感性来制定策略；4)调查分子/遗传和 通过了解导致女性癌症的环境条件进行可能的早期干预 早期细胞转化事件；5)通过了解以下知识开发针对女性癌症的靶向疗法 实体肿瘤进展/血管生成/侵袭的机制；以及6)识别靶点和开发新的， 合理、高效、低毒的治疗方法 肿瘤/运动/转移。

The Women's Cancers Program Area is composed of 19 members, spanning 7 Departments within UCLA. In the past competing cycle, investigators from this Program authored 199 publications, of which 39 (20%) were inter-programmatic and 27 (14%) intra-programmatic. 60 (30%) were placed in high-impact journals. 10 members of this Program Area used 5 out of the 8 Shared Resources that are currently funded by the JCCC. During the current funding year, peer-reviewed funding totaled $12.2 million in total costs, including $2.4 million from the National Cancer Institute. As with other Program Areas, JCCC fosters a number of interactive activities and many of the Shared Resources that support investigators in the Women's Cancers Program Area. During the current grant cycle, funds from the JCCC in the form of CCSG Developmental Funds, institutional support and philanthropic gifts to the GR Program Area total $991,008. These funds supported Interdisciplinary Grants, Seed Grants, recruitment/retention, Program Area Leadership support, funding for the use of emerging Shared Resources and trainees. Nine of the Program Area Members were the recipients of JCCC support. The Women's Cancers Program seeks to address research, clinical, and educational activities for malignancies in women. The Program fosters interactive and collaborative activities between and among members in order to develop multidisciplinary research in the areas of breast and women's reproductive cancers. It takes a comprehensive approach to clinical cancer research with a focus on translational research. The goals of the Women's Cancers Program are: 1) Establish genetic-based risk assessment and counseling by understanding high-risk/genetic predisposition; 2) Evaluate and implement prevention and screening strategies by understanding high-risk/genetic predisposition; 4) Investigate the molecular/genetic and environmental conditions that give rise to cancers in women for possible early intervention by understanding early cellular transformation events; 5) Develop targeted therapeutics for women's cancers by understanding the mechanisms of solid tumor progression/angiogenesis/invasion; and 6) Identify targets and develop new, rational, highly effective and minimally toxic therapeutic approaches by understanding established tumors/motility/metastasis.