INBRE: USC BEAUFORT: FACULTY AND UNDERGRADUATE RESEARCH DEVELOPMENT

INBRE：南加州大学博福特分校：教师和本科生研究发展

• 批准号: 8360745
• 负责人: Jane Upshaw
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360745
• 关键词: Admission activity; Agreement; Anatomy; Applied Research; Area; Biochemistry; Biomedical Research; Biotechnology; Core Facility; Crystallization; Dental; Educational Curriculum; Educational process of instructing; Electron Microscopy; Enrollment; Environment; Equipment; Faculty; Funding; Grant; Head; Histology; Home environment; Human Resources; Image; Industry; Institution; Internships; Joints; Laboratories; Lasers; Lead; Medical; Mentors; Microscope; Minority; National Center for Research Resources; Phase; Play; Principal Investigator; Publications; Qualifying; Race; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Role; Scanning; Side; Source; South Carolina; Students; Techniques; Tissue Engineering; Training; Training Programs; United States National Institutes of Health; Universities; Work; X-Ray Crystallography; college; cost; design; fluorescence microscope; high school; interest; meetings; programs; protein purification; research and development; research study; response; structural biology; theories; tissue culture; university student

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The University of South Carolina Beaufort (USCB) proposes to expand the USCB faculty to include expertise in biomedical fields necessary for training of premedical and other pre-professional students, and to develop a cluster of faculty whose research interests lie in the area of structural biology. The recent addition of pre-professional advisement to the USCB curriculum has stimulated intense interest among the students in pre-medical and pre-dental curricula. To meet these teaching needs, the faculty needs to be expanded to include more expertise in the areas of biochemistry and anatomy. In addition, the South Carolina Tissue Engineering Initiative will require students trained particularly in the area of structural biology. Having a group of faculty with similar interests will allow researchers to be optimally productive. Groups of faculty with similar interests a open the door to collaborative research, something that has particular value at an institution with a heavy teaching load. We propose to develop a cluster of faculty with interests in structural biology, to include the PI and two new hires, and to augment this cluster with a group of external advisors who will also act as mentors to the new hires. To develop a research program in structural biology, focused on tissue engineering, that will train students from diverse backgrounds in research theory and technique. While the new tenure-track faculty hires will be expected to develop independent research programs, they may also play a role in the SC Tissue Engineering initiative. Students from USCB will be recruited as research assistants, while students from the nearby Technical College of the Lowcountry will work in program laboratories as interns and research technicians. In order to provide the necessary infrastructure and environment for the new faculty and their students, USCB will establish an Imaging Core Facility, containing a laser scanning confocal microscope, a phase/fluorescence microscope, and inverted tissue culture microscopes. This facility will be available to all faculty in the department. In addition, a partnership with the Medical University of South Carolina will be implemented, allowing USCB faculty access to the world class imaging and structural analysis equipment at MUSC, including X-ray crystallography, NMR, protein purification and crystallization, electron microscopy, and histology. Students from USCB will be recruited to serve as research assistants in the laboratories of the new hires, and will be involved in all aspects of research, from experimental theory and design to publication of results, working side-by-side with their mentors in the daily conduction of experiments. In addition, USCB has established a connection with The Technical College of the Lowcountry (TCL), a small two year institution with campuses in close proximity to the north and south campuses of USCB. Students at TCL, even more than at USCB, come from impoverished homes, and from minority racial groups (48% minority students in 2008). In response to the growing need for a trained workforce in the biotechnology industry, TCL has recently begun a 2 year certificate program to train entry level technicians. The proposed partnership, which will establish internships for TCL students in the laboratories of USCB faculty, will result in a well trained biotechnology workforce in the Lowcountry. This partnership will be overseen at TCL by Dr. Joseph Bailey, the head of the biotechnology program. In addition to the proposed training program, USCB and TCL have formed several other partnerships and agreements that are relevant to this proposal. A new joint program has begun (PASSPORT) that allows students who apply to USCB but are lacking certain high school course requirements, who are otherwise qualified for admission, to attend TCL for one or two years to make up the coursework. These students are USCB students while at TCL, and are advised by USCB personnel. They switch to classes at USCB when the required courses are completed. In addition, TCL envisages establishing a 2 year Associate of Applied Science degree which could lead to an articulation with a 4 year university within South Carolina; TCL's proximity to USCB (the two Bluffton campuses are within one mile of each other) makes USCB an ideal partner for such an agreement. Since many of the minority applicants to USCB need a little additional help with coursework to be competitive for admission, these agreements are expected to enhance the ability of our local minority students to meet USCB requirements, and thereby increase the minority enrollment at the university. We anticipate that these agreements will also increase enrollment of minority students in USCB's STEM related degree programs, and increase the pool of minority students interested in working in the structural biology laboratories of this program.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 南卡罗来纳大学Beaufort大学（USCB）提议扩大USCB教师，以包括培训有前期和其他专业前学生所需的生物医学领域的专业知识，并开发一群研究兴趣的教师，其研究兴趣在于结构生物学领域。最近，在USCB课程中增加了专业咨询，这激发了学生对医学前和牙科前课程的强烈兴趣。为了满足这些教学需求，需要扩展教师，以在生物化学和解剖学领域包括更多的专业知识。此外，南卡罗来纳州组织工程计划将需要在结构生物学领域接受培训的学生。拥有一群具有相似兴趣的教师将使研究人员具有最佳的生产力。具有类似兴趣的教师团体为合作研究开辟了大门，这在具有沉重的教学负荷的机构中具有特殊价值。我们建议开发一群对结构生物学有兴趣的教师，包括PI和两名新员工，并与一群外部顾问一起增强这一集群，他们还将担任新员工的导师。为了制定着专注于组织工程的结构生物学研究计划，该计划将培训来自研究理论和技术不同背景的学生。尽管新的终身教师雇用将有望制定独立的研究计划，但他们也可能在SC组织工程计划中发挥作用。来自USCB的学生将被招募为研究助理，而附近的Lowcountry技术学院的学生将担任实习生和研究技术人员的计划实验室。为了为新教师及其学生提供必要的基础设施和环境，USCB将建立一个成像核心设施，其中包含激光扫描共聚焦显微镜，相/荧光显微镜和倒立的组织培养显微镜。该设施将适用于该系的所有教师。此外，还将与南卡罗来纳州医科大学建立合作伙伴关系，从而使USCB教师在MUSC上使用世界一流的成像和结构分析设备，包括X射线晶体学，NMR，NMR，蛋白质纯化和结晶，电子显微镜和组织学。 来自USCB的学生将被招募为新员工实验室的研究助理，并将参与研究的各个方面，从实验理论和设计到成果的出版，并与他们的导师并排工作，以每天进行实验传导。此外，USCB与Lowcountry技术学院（TCL）建立了联系，该学院的校园非常接近USCB的北部和南部校园。 TCL的学生甚至比USCB的学生来自贫困的房屋和少数种族群体（2008年有48％的少数民族学生）。为了应对生物技术行业中受过训练的劳动力的需求，TCL最近开始了一项为期2年的证书计划，以培训入门水平的技术人员。拟议的合作伙伴关系将在USCB教师实验室中为TCL学生建立实习，将在Lowcountry中提供训练有素的生物技术员工。该合作伙伴关系将由生物技术计划负责人约瑟夫·贝利（Joseph Bailey）博士在TCL监督。 除了拟议的培训计划外，U​​SCB和TCL还建立了与该提案相关的其他几项合作伙伴关系和协议。一项新的联合计划已经开始（护照），该计划允许向USCB申请但缺乏某些高中课程要求的学生，否则有资格获得入学的学生可以参加TCL一两年以弥补课程。在TCL时，这些学生是USCB学生，并由USCB人员提供建议。完成所需课程完成后，他们切换到USCB的课程。此外，TCL设想建立2年应用科学学位的副学士，这可能会导致与南卡罗来纳州一所4年的大学表达； TCL靠近USCB（两个Bluffton校园彼此一英里以内）使USCB成为该协议的理想合作伙伴。由于USCB的许多少数民族申请人在课程方面需要一些额外的帮助才能使入学竞争，因此这些协议有望提高我们当地少数族裔学生满足USCB要求的能力，从而增加大学的少数入学人数。我们预计，这些协议还将增加USCB STEM相关学位课程的少数族裔学生的入学率，并增加有兴趣从事该计划的结构生物学实验室工作的少数族裔学生的库。