INBRE: USC BEAUFORT: FACULTY AND UNDERGRADUATE RESEARCH DEVELOPMENT

INBRE：南加州大学博福特分校：教师和本科生研究发展

• 批准号: 8360745
• 负责人: Jane Upshaw
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360745
• 关键词: Admission activity; Agreement; Anatomy; Applied Research; Area; Biochemistry; Biomedical Research; Biotechnology; Core Facility; Crystallization; Dental; Educational Curriculum; Educational process of instructing; Electron Microscopy; Enrollment; Environment; Equipment; Faculty; Funding; Grant; Head; Histology; Home environment; Human Resources; Image; Industry; Institution; Internships; Joints; Laboratories; Lasers; Lead; Medical; Mentors; Microscope; Minority; National Center for Research Resources; Phase; Play; Principal Investigator; Publications; Qualifying; Race; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Role; Scanning; Side; Source; South Carolina; Students; Techniques; Tissue Engineering; Training; Training Programs; United States National Institutes of Health; Universities; Work; X-Ray Crystallography; college; cost; design; fluorescence microscope; high school; interest; meetings; programs; protein purification; research and development; research study; response; structural biology; theories; tissue culture; university student

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The University of South Carolina Beaufort (USCB) proposes to expand the USCB faculty to include expertise in biomedical fields necessary for training of premedical and other pre-professional students, and to develop a cluster of faculty whose research interests lie in the area of structural biology. The recent addition of pre-professional advisement to the USCB curriculum has stimulated intense interest among the students in pre-medical and pre-dental curricula. To meet these teaching needs, the faculty needs to be expanded to include more expertise in the areas of biochemistry and anatomy. In addition, the South Carolina Tissue Engineering Initiative will require students trained particularly in the area of structural biology. Having a group of faculty with similar interests will allow researchers to be optimally productive. Groups of faculty with similar interests a open the door to collaborative research, something that has particular value at an institution with a heavy teaching load. We propose to develop a cluster of faculty with interests in structural biology, to include the PI and two new hires, and to augment this cluster with a group of external advisors who will also act as mentors to the new hires. To develop a research program in structural biology, focused on tissue engineering, that will train students from diverse backgrounds in research theory and technique. While the new tenure-track faculty hires will be expected to develop independent research programs, they may also play a role in the SC Tissue Engineering initiative. Students from USCB will be recruited as research assistants, while students from the nearby Technical College of the Lowcountry will work in program laboratories as interns and research technicians. In order to provide the necessary infrastructure and environment for the new faculty and their students, USCB will establish an Imaging Core Facility, containing a laser scanning confocal microscope, a phase/fluorescence microscope, and inverted tissue culture microscopes. This facility will be available to all faculty in the department. In addition, a partnership with the Medical University of South Carolina will be implemented, allowing USCB faculty access to the world class imaging and structural analysis equipment at MUSC, including X-ray crystallography, NMR, protein purification and crystallization, electron microscopy, and histology. Students from USCB will be recruited to serve as research assistants in the laboratories of the new hires, and will be involved in all aspects of research, from experimental theory and design to publication of results, working side-by-side with their mentors in the daily conduction of experiments. In addition, USCB has established a connection with The Technical College of the Lowcountry (TCL), a small two year institution with campuses in close proximity to the north and south campuses of USCB. Students at TCL, even more than at USCB, come from impoverished homes, and from minority racial groups (48% minority students in 2008). In response to the growing need for a trained workforce in the biotechnology industry, TCL has recently begun a 2 year certificate program to train entry level technicians. The proposed partnership, which will establish internships for TCL students in the laboratories of USCB faculty, will result in a well trained biotechnology workforce in the Lowcountry. This partnership will be overseen at TCL by Dr. Joseph Bailey, the head of the biotechnology program. In addition to the proposed training program, USCB and TCL have formed several other partnerships and agreements that are relevant to this proposal. A new joint program has begun (PASSPORT) that allows students who apply to USCB but are lacking certain high school course requirements, who are otherwise qualified for admission, to attend TCL for one or two years to make up the coursework. These students are USCB students while at TCL, and are advised by USCB personnel. They switch to classes at USCB when the required courses are completed. In addition, TCL envisages establishing a 2 year Associate of Applied Science degree which could lead to an articulation with a 4 year university within South Carolina; TCL's proximity to USCB (the two Bluffton campuses are within one mile of each other) makes USCB an ideal partner for such an agreement. Since many of the minority applicants to USCB need a little additional help with coursework to be competitive for admission, these agreements are expected to enhance the ability of our local minority students to meet USCB requirements, and thereby increase the minority enrollment at the university. We anticipate that these agreements will also increase enrollment of minority students in USCB's STEM related degree programs, and increase the pool of minority students interested in working in the structural biology laboratories of this program.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 南卡罗来纳州博福特（USCB）的大学建议扩大USCB的教师，包括必要的医学预科和其他预科专业学生的培训生物医学领域的专业知识，并开发一个集群的教师，其研究兴趣在于结构生物学领域。最近增加的职前教育的USCB课程，激发了学生在医学预科和牙科预科课程的浓厚兴趣。为了满足这些教学需求，教师需要扩大，包括在生物化学和解剖学领域的更多专业知识。此外，南卡罗来纳州组织工程倡议将要求学生特别是在结构生物学领域的培训。拥有一群具有相似兴趣的教师将使研究人员能够获得最佳生产力。具有相似兴趣的教师群体为合作研究打开了大门，这在教学负担沉重的机构中具有特别的价值。我们建议开发一个对结构生物学感兴趣的教师集群，包括PI和两名新员工，并通过一组外部顾问来增加这一集群，这些顾问也将担任新员工的导师。开发一个结构生物学的研究计划，重点是组织工程，这将培养来自不同背景的学生在研究理论和技术。虽然新的终身教职员工将有望开发独立的研究项目，但他们也可能在SC组织工程计划中发挥作用。来自USCB的学生将被招募为研究助理，而来自附近低地技术学院的学生将作为实习生和研究技术人员在项目实验室工作。为了提供必要的基础设施和环境，为新的教师和他们的学生，USCB将建立一个成像核心设施，包括激光扫描共聚焦显微镜，相位/荧光显微镜，倒置组织培养显微镜。该设施将提供给该部门的所有教师。此外，还将与南卡罗来纳州医科大学建立合作伙伴关系，使USCB教师能够使用MUSC的世界级成像和结构分析设备，包括X射线晶体学，NMR，蛋白质纯化和结晶，电子显微镜和组织学。 来自USCB的学生将被招募担任新员工实验室的研究助理，并将参与研究的各个方面，从实验理论和设计到结果的发布，与他们的导师并肩工作在日常实验中进行。此外，USCB还与低地技术学院（TCL）建立了联系，这是一所小型的两年制机构，校园靠近USCB的南北校区。TCL的学生来自贫困家庭和少数民族群体（2008年48%的少数民族学生），比USCB的学生还要多。为了满足生物技术行业对训练有素的劳动力日益增长的需求，TCL最近开始了一项为期两年的证书计划，以培训入门级技术人员。拟议的合作伙伴关系，这将建立实习TCL学生在USCB教师的实验室，将导致在低地训练有素的生物技术劳动力。TCL将由生物技术项目负责人Joseph Bailey博士监督这一合作关系。 除了拟议的培训计划外，USCB和TCL还建立了与本提案相关的其他几个伙伴关系和协议。一个新的联合项目已经开始（PASSPORT），允许申请USCB但缺乏某些高中课程要求的学生，他们有资格入学，参加TCL一年或两年的课程，以弥补课程。这些学生是在TCL的USCB学生，并由USCB人员提供建议。当必修课程完成后，他们会转到USCB上课。此外，TCL设想建立一个为期2年的应用科学学位，这可能导致与南卡罗来纳州内的4年制大学衔接; TCL靠近USCB（两个布拉夫顿校区相距不到一英里），使USCB成为此类协议的理想合作伙伴。由于许多申请USCB的少数民族学生需要额外的课程帮助才能获得入学竞争力，这些协议有望提高我们当地少数民族学生满足USCB要求的能力，从而增加大学的少数民族入学率。我们预计，这些协议也将增加少数民族学生在USCB的STEM相关学位课程的入学率，并增加有兴趣在该计划的结构生物学实验室工作的少数民族学生的人数。