Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction

DLPFC 和杏仁核成像对可卡因成瘾相对偏好的影响

• 批准号: 8317695
• 负责人: HANS C BREITER
• 金额: $ 42.49万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8317695
• 关键词: Abstinence; Amygdaloid structure; Animals; Aversive Stimulus; Behavior; Behavioral; Brain; Clinical; Cocaine; Cocaine Dependence; Complex; Data; Decision Making; Deltastab; Development; Disease; Drug Addiction; Drug Exposure; Drug usage; Financial compensation; Functional Imaging; Goals; Human; Image; Individual; Insula of Reil; Intelligence; Investments; Judgment; Literature; MRI Scans; Matched Group; Measures; Pharmaceutical Preparations; Predisposition; Prefrontal Cortex; Process; Relative (related person); Resolution; Rewards; Risk; Structure; Testing; Thick; Weight; Work; abstracting; active control; addiction; approach avoidance behavior; base; behavior test; healthy volunteer; interest; neuroimaging; polysubstance abuse; preference; response

Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction Abstract Relatively recently, studies of the relationship of brain structural measures and reward/aversion processing have started to appear. One challenge with studies showing altered brain structure in relationship to altered approach and avoidance behaviors in addiction is that it is difficult to interpret whether the findings relate to (i) vulnerability factors, (ii) effects of drug exposure/damage, or (iii) compensatory responses to the illness. From the literature, results regarding structure asymmetry, correlations with behavior, and responses to abstinence are emerging that suggest we can develop and test hypotheses that weight interpretation toward vulnerability, drug exposure/damage, or compensation. We propose to evaluate the relationship of brain structure with keypress measures of relative preference, including strongly aversive ones, and determine if findings can be extended to healthy controls, or related to vulnerability factors, signs of drug exposure, or compensatory responses in cocaine dependent polysubstance abusing (CDPA) subjects. We will specifically target the amygdala, insula (INS), and dorsolateral prefrontal cortex (DLPFC), given each of these regions has been functionally connected with keypress tasks related to judgment and decision-making based on relative preferences, or structurally connected with keypress tasks in CDPA subjects. We predict that alterations in: (1) the amygdala relate to vulnerability, (2) the INS relate to drug exposure, and (3) the DLPFC relate to compensatory responses. These hypotheses will be tested by behavioral testing with keypress tasks and high- resolution MRI scanning of matched groups (N=80 each) who are (1) active CDPA subjects, (2) long-term abstinent CDPA subjects, and (3) healthy volunteers. Brain structure and behavior will be specifically tested for differences between these three groups, and for altered relationships between structure and behavior to draw inferences on (a) whether structural measures in the DLPFC, INS, and amygdala can be connected to keypress behavior to approach and avoid goal-objects in healthy controls, and (b) whether abnormalities in CDPA subjects can be interpreted in terms of vulnerability, drug exposure, or compensatory responses.

DLPFC和杏仁核对可卡因相对偏好的影响 瘾 抽象的 相对较最近，研究大脑结构测量与 奖励/厌恶处理已经开始出现。研究表明的一个挑战 与改变的方法和回避行为的关系改变了大脑结构 成瘾是很难解释发现是否与（i）脆弱性有关 因素，（ii）药物暴露/损害的影响，或（iii）对 疾病。从文献中，关于结构不对称的结果，与 行为和对禁欲的反应正在出现，这表明我们可以发展和 测试假设对脆弱性，药物暴露/损害的重量解释， 或赔偿。我们建议评估大脑结构与 按键相对偏好的措施，包括强烈厌恶的措施，以及 确定发现是否可以扩展到健康控制，或与脆弱性有关 可卡因依赖性的因素，药物暴露的迹象或补偿性反应 滥用多物质（CDPA）受试者。我们将专门针对杏仁核，岛 （INS）和背外侧前额叶皮层（DLPFC），给定每个区域都 在功能上与与判断和决策有关的按键任务连接 基于相对偏好或与CDPA中的键盘任务连接的结构连接 主题。我们预测：（1）杏仁核与脆弱性有关，（2） INS与药物暴露有关，（3）DLPFC与补偿性反应有关。 这些假设将通过按键任务和高度测试进行行为测试来测试 分辨率的MRI扫描（n = 80）是（1）主动CDPA 受试者，（2）长期戒律的CDPA受试者和（3）健康志愿者。脑 结构和行为将被专门测试这三个 组，以及结构与行为之间的改变关系以提出推断 （a）是否可以连接DLPFC，INS和杏仁核中的结构测量 键盘行为接近并避免健康控制中的目标对象，并且（b） CDPA受试者的异常是否可以用脆弱性，药物来解释 暴露或补偿性反应。