Human Brain Functional and Structural Interactions Between Chronic Pain and Opioi
Human Brain Functional and Structural Interactions Between Chronic Pain and Opioi
批准号:
7608892
负责人:
HANS C BREITER
金额:
$33.56万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-09-15 至 2012-06-30
关键词:
AcuteAddictive BehaviorAmygdaloid structureAnalgesicsAnatomyAnimalsAttenuatedAversive StimulusBackBehaviorBrainBrain regionCategoriesChronicClinicalConditionControl GroupsCuesDiagnosisDiseaseEventExperimental DesignsExperimental PsychologyExposure toFunctional Magnetic Resonance ImagingHippocampus (Brain)HumanIllicit DrugsImageIndividualJudgmentMeasuresMedialMedicineModelingMolecularNegative FindingNeurophysiology - biologic functionNeurosciencesNon-MalignantNucleus AccumbensOpiate AddictionOpiatesOpioidOpioid AnalgesicsOrganismOutcome MeasureOutcomes ResearchPainPain managementPatientsPharmaceutical PreparationsPhenotypePrefrontal CortexProcessPurposeRecording of previous eventsRelative (related person)ResearchRewardsRodentRodent ModelSensorySeveritiesSignal TransductionStructureSubstantia nigra structureSymptomsTestingVentral Tegmental Areaaddictionattenuationbasechronic painclinical applicationcohortdesirehuman subjectinterestmorphometryneuroimagingpre-clinicalpreclinical studypreferenceprescription documentprescription procedurepsychologicrelating to nervous systemresearch clinical testingresearch studyresponsereward processing
中文摘要
本P20中心研究计划的项目1将以人类受试者为研究对象,研究相互作用
英文摘要
Project 1 of this P20 center research plan will focus on human subjects to examine the interaction of
functional and structural circuitry alterations in chronic pain and opioid addiction. It will specifically examine
two separate cohorts of subjects for test/retest purposes, each cohort comprising five groups of human
subjects who represent a continuum between opioid addiction and chronic pain. These five groups will
include: (i) individuals with addiction to opiates who have no history of chronic pain, (ii) individuals with
chronic pain who have developed addictive behaviors toward opioid analgesics, (iii) individuals with chronic
pain who have treatment based exposure to analgesics but no addiction behavior, and (iv) individuals with
chronic pain who have no exposure to analgesics. A fifth group of healthy controls (v) with neither chronic
pain nor addiction to opioid analgesics will serve as a baseline control group for the four clinical groups (i) -
(iv). Across these groups of subjects in each of the two cohorts, we will compare and contrast BOLD signal
measured by functional MRI in a limited set of reward/aversion brain regions that have been implicated in
both addiction and chronic pain, such as the nucleus accumbens, amygdala/hippocampus, ventral
tegmentum, and regions of the prefrontal cortex. Neural function will be assessed against morphometric and
topological measures across the five groups of human subjects. We hypothesize that opioid addiction and
chronic pain will modulate reward/aversion behavior and function in apriori regions in a convergent direction
and share phenotypic features, correlating with altered morphometry measures. Across three specific aims,
we will test if mildly rewarding or aversive stimuli elicit attenuated responses across the four clinical groups
with addiction and/or chronic pain, and whether strongly aversive stimuli elicit hypersensitive responses. Aim
1 will assess differences in reward processing using a keypress paradigm testing judgment and decisionmaking
around relative preference for drug cues or phenotypic features of addiction. Aim 2 will compare and
contrast physical and psychological aversion across the five human groups using thermal pain and monetary
losses in a game of chance. Aim 3 will determine if brain structural/topological alterations in addiction are
also found in chronic pain, and assess the interactions of structural/topological differences with symptom
severity and functional differences from Aims 1 and 2.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction
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批准号:8317695
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项目类别:
-
资助金额:$42.49万
-
财政年份:2009
-
负责人:HANS C BREITER
-
依托单位:
Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction
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批准号:7935469
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项目类别:
-
资助金额:$43.81万
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财政年份:2009
-
负责人:HANS C BREITER
-
依托单位:
Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction
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批准号:8131906
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项目类别:
-
资助金额:$42.49万
-
财政年份:2009
-
负责人:HANS C BREITER
-
依托单位:
Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction
-
批准号:8532868
-
项目类别:
-
资助金额:$40.79万
-
财政年份:2009
-
负责人:HANS C BREITER
-
依托单位:
Imaging of DLPFC and amygdala impact on relative preference in cocaine addiction
-
批准号:7776495
-
项目类别:
-
资助金额:$42.84万
-
财政年份:2009
-
负责人:HANS C BREITER
-
依托单位:
Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic
-
批准号:8103193
-
项目类别:
-
资助金额:$65.96万
-
财政年份:2008
-
负责人:HANS C BREITER
-
依托单位:
Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic
-
批准号:7687503
-
项目类别:
-
资助金额:$33.73万
-
财政年份:2008
-
负责人:HANS C BREITER
-
依托单位:
Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic
-
批准号:8087594
-
项目类别:
-
资助金额:$68.01万
-
财政年份:2008
-
负责人:HANS C BREITER
-
依托单位:
Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic
-
批准号:7588306
-
项目类别:
-
资助金额:$33.76万
-
财政年份:2008
-
负责人:HANS C BREITER
-
依托单位:
Functional Spectroscopy with Real-Time Feedback for Altering Preferences in Addic
-
批准号:8292242
-
项目类别:
-
资助金额:$64.35万
-
财政年份:2008
-
负责人:HANS C BREITER
-
依托单位:
PHENOTYPE GENOTYPE PROJECT IN ADDICTION AND MOOD DISORDERS
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批准号:7607061
-
项目类别:
-
资助金额:$1.8万
-
财政年份:2006
-
负责人:HANS C BREITER
-
依托单位:
PHENOTYPE GENOTYPE PROJECT IN ADDICTION AND MOOD DISORDERS
-
批准号:7374756
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项目类别:
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION -- ALTERATIONS IN REWARD CIRCUITRY
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批准号:6523322
-
项目类别:
-
资助金额:$14.6万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION -- ALTERATIONS IN REWARD CIRCUITRY
-
批准号:6695990
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项目类别:
-
资助金额:$20.0万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION -- ALTERATIONS IN REWARD CIRCUITRY
-
批准号:6803607
-
项目类别:
-
资助金额:$34.6万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION -- ALTERATIONS IN REWARD CIRCUITRY
-
批准号:6944787
-
项目类别:
-
资助金额:$34.6万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION -- ALTERATIONS IN REWARD CIRCUITRY
-
批准号:6668637
-
项目类别:
-
资助金额:$34.6万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
COCAINE ADDICTION--ALTERATIONS IN REWARD CIRCUITRY
-
批准号:6333913
-
项目类别:
-
资助金额:$34.6万
-
财政年份:2001
-
负责人:HANS C BREITER
-
依托单位:
WAFARIN ASPIRIN RECURRENT STROKE STDY--WARSS & HEMOSTATISTIC SYS ACT SUBSTDY
-
批准号:6250222
-
项目类别:
-
资助金额:$2.24万
-
财政年份:1997
-
负责人:HANS C BREITER
-
依托单位:
FMRI STUDIES OF BRAIN REWARD AND EMOTION
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批准号:2429987
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项目类别:
-
资助金额:$14.74万
-
财政年份:1995
-
负责人:HANS C BREITER
-
依托单位:
海外基金