Bronchial Vascular Proliferation and Function

支气管血管增殖和功能

基本信息

  • 批准号:
    8197296
  • 负责人:
  • 金额:
    $ 40.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-12-10 至 2014-06-30
  • 项目状态:
    已结题

项目摘要

Under conditions of chronic pulmonary artery ischemia, the systemic bronchial circulation undergoes massive proliferation. However, the functional consequences of this rapidly constructed new circulation remain largely unexplored. Systemic angiogenic beds in general have been shown to demonstrate a proinflammatory phenotype. Our laboratory has studied systemic angiogenesis in mice after chronic left pulmonary artery ligation where ELR+ CXC chemokines appear to play a role in intercostal artery angiogenesis. However, since mice lack an intraparenchymal bronchial circulation and therefore are unlike humans, a larger animal model is required to determine the physiology of the angiogenic bronchial vasculature within the lung. In this application, we propose to study the process and consequences of bronchial vascular growth and proliferation after left pulmonary artery obstruction in rats, a species known to display a bronchial vascular anatomy similar to humans. An underlying question in this model is how growth factors released within the perfusion-starved lung, communicate with distant, upstream bronchial vessels. We propose a conduit role for lung lymphatic vessels, which drain unidirectionally and in proximity to major bronchial arteries. We hypothesize that bronchial angiogenesis is dependent on growth factors (CXC chemokines) released by trapped inflammatory cells, that drain and diffuse through lung lymphatics and mediastinal lymph nodes, causing bronchial vascular proliferation and enlargement. Furthermore, we hypothesize that the neovasculature is like other systemic beds and is proinflammatory (vasodilated, hyperpermeable, leukocyte recruiting) within the lung. In a rat model of left pulmonary artery obstruction, we will determine the importance of proangiogenic ELR+ CXC chemokines for the growth of new bronchial blood vessels, determine whether mediastinal lymph drainage provides a mechanism whereby parenchymal growth factors transit upstream to promote bronchial angiogenesis, and measure bronchial vascular function (permeability, inflammation, vasoreactivity) at time points before and after a new vasculature is established. Results will provide new information concerning the mechanisms of bronchial vascular angiogenesis, function and impact on ischemic parenchyma. Furthermore, results may explain properties of bronchial vessels that contribute to hemoptysis and loss of pulmonary function.
在慢性肺动脉缺血的情况下,全身支气管循环经历

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Chemokine localization in bronchial angiogenesis.
支气管血管生成中的趋化因子定位。
  • DOI:
    10.1371/journal.pone.0066432
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Perino,MariaGrazia;Moldobaeva,Aigul;Jenkins,John;Wagner,ElizabethM
  • 通讯作者:
    Wagner,ElizabethM
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Elizabeth Wagner其他文献

Elizabeth Wagner的其他文献

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{{ truncateString('Elizabeth Wagner', 18)}}的其他基金

Bronchial Vascular Proliferation and Function
支气管血管增殖和功能
  • 批准号:
    7577107
  • 财政年份:
    2008
  • 资助金额:
    $ 40.59万
  • 项目类别:
Bronchial Vascular Proliferation and Function
支气管血管增殖和功能
  • 批准号:
    7746434
  • 财政年份:
    2008
  • 资助金额:
    $ 40.59万
  • 项目类别:
Effects of Distension on the Airway Vasculature
扩张对气道脉管系统的影响
  • 批准号:
    7392280
  • 财政年份:
    2007
  • 资助金额:
    $ 40.59万
  • 项目类别:
Effects of Distension on the Airway Vasculature
扩张对气道脉管系统的影响
  • 批准号:
    7312429
  • 财政年份:
    2006
  • 资助金额:
    $ 40.59万
  • 项目类别:
Effects of Distension on the Airway Vasculature
扩张对气道脉管系统的影响
  • 批准号:
    6967834
  • 财政年份:
    2004
  • 资助金额:
    $ 40.59万
  • 项目类别:
Angiogenesis in the Lung
肺部血管生成
  • 批准号:
    6768778
  • 财政年份:
    2003
  • 资助金额:
    $ 40.59万
  • 项目类别:
Angiogenesis in the Lung
肺部血管生成
  • 批准号:
    6687131
  • 财政年份:
    2003
  • 资助金额:
    $ 40.59万
  • 项目类别:
Angiogenesis in the Lung
肺部血管生成
  • 批准号:
    7924795
  • 财政年份:
    2003
  • 资助金额:
    $ 40.59万
  • 项目类别:
Angiogenesis in the Lung
肺部血管生成
  • 批准号:
    7727635
  • 财政年份:
    2003
  • 资助金额:
    $ 40.59万
  • 项目类别:
Angiogenesis in the Lung
肺部血管生成
  • 批准号:
    6904595
  • 财政年份:
    2003
  • 资助金额:
    $ 40.59万
  • 项目类别:

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