What language does the motor cortex use to speak to motoneurons?

运动皮层使用什么语言与运动神经元对话?

基本信息

项目摘要

DESCRIPTION (provided by applicant): What language does the motor cortex use to speak to motoneurons? The primary motor cortex (M1) is a major source of descending commands to the spinal cord for generating motor output. Approximately 50% of the corticospinal neurons from the frontal lobe originate from M1. A special set of these corticospinal neurons are corticomotoneural (CM cells) which have direct connections to motoneurons. We will investigate CM cells using a combination of behavioral, electrophysiological and anatomical methods. We propose to provide, for the first time, a clear and consistent view of signaling from CM cells to motoneurons. We will identify CM cells and their target muscles using spike-triggered averaging (SpTA) of electromyographic (EMG) activity. The activity of CM cells and their target muscles will be investigated in relation to wrist movements involved in a multi-directional wrist task capable of dissociating intrinsic (muscle-like) and extrinsic (movement-like) parameters of wrist movement. Previous studies have shown that both intrinsic and extrinsic parameters are present in M1 activity (Kakei et al., 1999). One way to explain the presence of both "muscles" and "movements" is the existence of a hierarchy. The hierarchy hypothesis would predict that CM cell activity is muscle like and non-CM cell activity is movement like. In other words, direct input to motoneurons is in a language that does not need to be translated. The alternative is that a mixture of muscle-like and movement-like activity reaches the motoneuron and is used to create movements under different conditions. This project will determine which hypothesis is correct. We will also document, for the first time, the location and distribution of CM cells projecting to wrist muscle motoneurons. We will use the transneuronal transport of rabies virus to define the location of CM cells in the motor cortex that influence antagonist wrist muscles; flexor carpi radialis and extensor carpi radialis. If time permits, we will compare the distribution of CM cells in naive animals to those of animals trained to perform a skilled wrist task. This experiment will enable us to determine whether extensive training alters the cortical territory of CM cells in M1.
描述(由申请人提供):运动皮层用什么语言与运动神经元对话?初级运动皮层(M1)是向脊髓下行指令的主要来源,以产生运动输出。额叶约50%的皮质脊髓神经元来源于M1。一组特殊的皮质脊髓神经元是皮质神经细胞(CM细胞),它与运动神经元有直接的联系。我们将结合行为学、电生理学和解剖学的方法来研究CM细胞。我们首次提出了CM细胞向运动神经元传递信号的清晰一致的观点。我们将使用肌电图(EMG)活动的峰值触发平均(SpTA)来识别CM细胞和它们的目标肌肉。CM细胞及其靶肌肉的活动将被研究与手腕运动有关的多向手腕任务,该任务能够分离手腕运动的内在(肌肉样)和外在(运动样)参数。先前的研究表明,M1活性中既有内在参数,也有外在参数(Kakei et al., 1999)。解释“肌肉”和“动作”同时存在的一种方法是存在等级制度。层次假设预测CM细胞的活动是肌肉样的,而非CM细胞的活动是运动样的。换句话说,对运动神经元的直接输入是一种不需要翻译的语言。另一种方法是,类似肌肉和类似运动的混合活动到达运动神经元,并用于在不同条件下产生运动。这个项目将决定哪个假设是正确的。我们也将首次记录CM细胞投射到手腕肌肉运动神经元的位置和分布。我们将使用狂犬病毒的跨神经元转运来确定CM细胞在运动皮质中影响拮抗剂腕肌的位置;桡侧腕屈肌和桡侧腕伸肌。如果时间允许,我们将比较CM细胞的分布在幼稚的动物和那些受过训练的动物执行一个熟练的手腕任务。该实验将使我们能够确定广泛的训练是否会改变M1中CM细胞的皮质区域。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Darcy M. Griffin其他文献

muscles in the macaque monkey Properties of primary motor cortex output to hindlimb
猕猴的肌肉初级运动皮层输出到后肢的特性
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Heather M. Hudson;Darcy M. Griffin;A. Belhaj
  • 通讯作者:
    A. Belhaj
Neural Hijacking
神经劫持
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Paul D. Cheney;Darcy M. Griffin;G. M. V. Acker
  • 通讯作者:
    G. M. V. Acker
Finger Movements in Humans Decoupling the Cortical Power Spectrum Reveals Real-Time Representation of Individual
人类手指运动解耦皮质功率谱揭示个体的实时表征
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. Fox;M. Cykowski;O. Coulon;P. Kochunov;K. Amunts;J. Lancaster;A. Laird;A. d’Avella;L. Fernandez;A. Portone;F. Lacquaniti;Darcy M. Griffin;Heather M. Hudson;A. Belhaj;P. Cheney;K. Miller;S. Zanos;E. Fetz;M. Nijs;J. Ojemann
  • 通讯作者:
    J. Ojemann
Motor Cortex: Evidence for a Recurrent Neural On the Nature of the Intrinsic Connectivity of the Cat
运动皮层:循环神经元关于猫内在连通性本质的证据
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. Capaday;L. Brizzi;A. Sik;Darcy M. Griffin;Heather M. Hudson;A. Belhaj;P. Cheney;N. Kouchtir;F. Cassim;P. Derambure
  • 通讯作者:
    P. Derambure
Altered By Elbow Angle Mapping From Motor Cortex to Biceps and Triceps
通过从运动皮层到二头肌和三头肌的肘部角度映射来改变
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Graziano;Kaushal Patel;Charlotte S. R. Taylor;H. Adelsberger;A. Zainos;Manuel Alvarez;R. Romo;A. Konnerth;Darcy M. Griffin;Heather M. Hudson;A. Belhaj;P. Cheney;C. Luchies;G. Acker;Sommer L. Amundsen;William G. Messamore;Hongyu Y. Zhang
  • 通讯作者:
    Hongyu Y. Zhang

Darcy M. Griffin的其他文献

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{{ truncateString('Darcy M. Griffin', 18)}}的其他基金

What language does the motor cortex use to speak to motoneurons?
运动皮层使用什么语言与运动神经元对话?
  • 批准号:
    8122630
  • 财政年份:
    2011
  • 资助金额:
    $ 5.39万
  • 项目类别:
What language does the motor cortex use to speak to motoneurons?
运动皮层使用什么语言与运动神经元对话?
  • 批准号:
    8476282
  • 财政年份:
    2011
  • 资助金额:
    $ 5.39万
  • 项目类别:

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