BEHAVIORAL TESTING

行为测试核心位于BBSRB地下室的两个房间内。B028是一个专门的老鼠行为评估室，其中Core有能力执行a)使用Morris水迷宫系统对学习和记忆进行认知测试，b)使用胡须滋扰任务进行感觉测试，c)使用Hargreaves足底设备进行伤害性测试，以及d)使用Basso，Beattie，Bresna han(BBB)量表和脚部错位装置(水平梯子)进行运动功能测试。 B030是一个专门用于小鼠行为评估的房间，其中Core具有使用白色Morris水迷宫(用于黑鼠)或黑色迷宫(用于白鼠)与更新的数字跟踪系统一起执行学习和记忆认知测试的能力。还可以使用转弯试验评估小鼠的感觉运动功能，使用转杆装置评估前庭运动能力，并使用综合神经评分、神经严重程度评估简单和复杂的运动功能。 得分。Basso鼠标秤(BMS)、握力测力仪和弦测试。用P30基金购买的具体仪器包括2台AccuScan Instruments EzVideoDV自动跟踪系统数字系统、一台Columbus Instruments Rotamex-5和脚部错位装置、2台止痛仪和一个用于野外运动评估的涉水池。凯瑟琳·萨特曼博士领导行为测试核心 以及助理核心总监亚历山大·拉布切夫斯基。Stephen Onifer博士提供核心运营的日常管理，并监督培训、数据存储和传播以及核心使用。 两名在啮齿动物脑损伤模型(Jennifer Pleasant女士，25%努力)和SCI模型(Travis Lyttle先生，25%努力)方面接受过行为测试培训的高级技术人员，帮助和指导新的核心用户进行行为评估。

The Behavioral Testing Core is housed within two rooms in the basement of BBSRB. B028 is a dedicated room for behavioral assessment of rats, in which the Core has the capability of performing a) cognitive testing of learning and memory using a Morris water maze system, b) sensory testing using a whisker nuisance task, c) nociceptive testing using a Hargreaves plantar device, and d) locomotor function testing using the Basso, Beattie, Bresnahan (BBB) scale and the foot misplacement apparatus (horizontal ladder). B030 is a dedicated room for behavioral assessment of mice, in which the Core has the capability of performing cognitive testing of learning and memory using a white Morris water maze (for black mice) or a black maze (for white mice) in conjunction with an updated digital tracking system. Mice can also be evaluated for sensorimotor function using a corner turn test, vestibulomotor ability using the rotarod apparatus, and simple and complex motor function using the composite neuroscore, neurological severity score. Basso mouse scale (BMS), grip strength meter, and string test. Specific instruments purchased with P30 funds include 2 AccuScan Instruments EzVideoDV Automated Tracking System Digital Systems, a Columbus Instruments Rotamex-5 and Foot Misplacement Apparatus, 2 analgesia meters and a wading pool for open field locomotor assessment. Kathryn Saatman, Ph.D. directs the Behavioral Testing Core along with Assistant Core Director, Alexander Rabchevsky. Stephen Onifer, Ph.D provide day-to-day management of core operations and overseeing training, data storage and dissemination, and core usage. Two senior technicians who are trained in behavioral testing in rodent TBI models (Ms. Jennifer Pleasant, 25% effort) and SCI models (Mr. Travis Lyttle, 25% effort) assist and instruct new core users with the behavioral assessments.