Neurobiology of CNS Injury and Repair

中枢神经系统损伤与修复的神经生物学

• 批准号: 10200898
• 负责人: KATHRYN E SAATMAN
• 金额: $ 4.62万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200898
• 关键词: Neurobiology; central nervous system injury; injury and repair

PROJECT SUMMARY/ABSTRACT This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows working toward their Ph.D. degrees. During the first 4 years of the original funding period, 11 trainees have been appointed to the 2 year program, of which 5 have completed training and their Ph.D.s (3 in Physiology and 2 in Anatomy & Neurobiology). Of those 5, 2 are currently postdoctoral fellows, 2 have been hired into university faculty positions and 1 has moved on to medical school. Of the other 6 trainees, 2 are expected to finish their Ph.D.s during year 5 of the initial funding period. The remaining 4 are anticipated to complete their doctorates within the next two to three years. The training of the predoctoral fellows will be mainly carried out by training faculty whose primary appointments are either within the University of Kentucky (UK) Spinal Cord & Brain Injury Research Center (SCoBIRC) or are the affiliated with it as SCoBIRC Faculty Associates. Three of the SCoBIRC faculty associates have their primary appointments within the UK Sanders-Brown Center on Aging (SBCoA). In addition to their primary appointments, the SCoBIRC and/or SBCoA training faculty have their academic appointments in one of three UK College of Medicine basic science departments: Anatomy & Neurobiology, Physiology, or Molecular & Cellular Biochemistry. One additional training faculty is from the UK College of Pharmacy Department of Pharmaceutical Sciences. The overall goal of the proposed program will continue to be providing broad-based training in modern research concepts regarding the acute, subacute and chronic pathophysiology of SCI, TBI and stroke, and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene therapeutic strategies by which the devastating effects of these injuries can be ameliorated. These strategies will include both “neuroprotective” and “neurorestorative” approaches. Although it is anticipated that most of the trainees will pursue careers in laboratory-based therapeutic discovery research, they will also receive training in clinical aspects of the targeted neurological disorders and the practical issues involved in the design and conduct of neurological clinical trials. To accomplish this, the predoctoral fellows will spend one day/week for a semester shadowing one of 6 Clinical Tutors from the Departments Neurosurgery and Physical Medicine & Rehabilitation, and will attend weekly grand rounds to gain an understanding of the clinical nature of TBI and SCI upon which their research is focused. This will enhance their ability as independent investigators to not only make therapeutic discoveries in experimental neurotrauma and stroke injury models, but also provide them with knowledge concerning how to design their basic research in a manner that will more readily enable the translation of promising therapeutic approaches into clinical studies and therapeutic trials.

项目摘要/摘要 这是一份续签申请，要求继续为中枢神经系统损伤的神经生物学和 修复T32培训计划，以支持4名博士前研究员攻读博士学位。 在最初资助期的头四年，11名学员被任命为第二年的学员。 计划，其中5人已完成培训并获得博士学位(3人生理学，2人解剖学和 神经生物学)。在这5人中，2人目前是博士后研究员，2人已受聘为大学教员。 其中1人已进入医学院学习。在其他6名实习生中，有2名预计将完成学业 在最初资助期的第5年获得博士学位。其余4个预计将完成他们的 在未来两到三年内获得博士学位。主要对博士后研究员进行培训 通过培训主要任职于肯塔基大学(英国)的教职员工 脊髓和脑损伤研究中心(SCoBIRC)或附属于该中心的SCoBIRC教员 合伙人。SCoBIRC的三名教员助理的主要任命是在英国 桑德斯-布朗老龄化中心(SBCoA)。除了主要任命外，SCoBIRC 和/或SBCoA培训教师在三所英国医学院中的一所担任学术职务 基础科学系：解剖学与神经生物学、生理学或分子与细胞生物化学。 另一名培训教师来自英国药学院药学系 科学。拟议方案的总体目标将继续是在以下方面提供广泛的培训 急性、亚急性和慢性脊髓损伤、脑损伤和脑损伤的现代研究概念 中风，以及可能推动这一发现的潜在疾病修改分子靶点的识别 药物或基因治疗策略，通过这些策略，这些损伤的破坏性影响可以 被改进了。这些策略将包括“神经保护性”和“神经恢复性”两种方法。 尽管预计大多数受训人员将从事以实验室为基础的治疗工作 发现研究，他们还将接受针对神经学的临床方面的培训 神经学临床试验设计和实施中涉及的障碍和实际问题。至 要做到这一点，博士前研究员将花一天/一周的时间跟踪6个学期中的一个 神经外科和物理医学与康复学系的临床导师 参加每周一次的大型查房，了解脑外伤和脊髓损伤的临床性质，并在此基础上 他们的研究是集中的。这将增强他们作为独立调查人员的能力，不仅 在实验性神经创伤和中风损伤模型中的治疗发现，但也提供了它们 了解如何以更容易实现的方式设计他们的基础研究 将有希望的治疗方法转化为临床研究和治疗试验。