Neurobiology of CNS Injury and Repair

项目总结/摘要 这是一份更新申请，要求继续资助CNS损伤的神经生物学， 修复T32培训计划，以支持4名博士前研究员攻读博士学位。度 在最初的资助期的头4年，11名学员被任命为2年 计划，其中5人已完成培训和他们的博士学位（3在生理学和2在解剖学和 神经生物学）。在这5人中，2人目前是博士后研究员，2人已被聘为大学教师 1人已进入医学院。在其他6名受训人员中，预计有2人将完成 在初始资助期的第5年获得博士学位。其余4人预计将完成其 在未来两到三年内获得博士学位。博士前研究员的培训将主要进行 通过培训教师，其主要任命是在肯塔基州（英国）的大学 脊髓和脑损伤研究中心（SCoBIRC）或附属于它作为SCoBIRC教师 合伙人三个SCoBIRC教职员工有他们的主要任命在英国 Sanders-Brown Center on Aging（SBCoA）除了他们的主要任命，SCoBIRC 和/或SBCoA培训教师在英国三所医学院之一有学术任命 基础科学部门：解剖学和神经生物学，生理学，或分子和细胞生物化学。 一个额外的培训教师来自英国药学院药学系 以理工科为重拟议方案的总体目标将继续是提供基础广泛的培训， 关于SCI、TBI和TBI的急性、亚急性和慢性病理生理学的现代研究概念， 中风，并确定潜在的疾病修饰分子靶点，可以推动发现 药物或基因治疗策略，通过这些伤害的破坏性影响， 得到改善。这些策略将包括“神经保护”和“神经恢复”方法。 虽然预计大多数受训人员将从事实验室治疗的职业， 发现研究，他们还将接受培训，在临床方面的目标神经 疾病和实际问题的设计和神经临床试验的进行。到 完成这一点，博士前研究员将花一天/一个学期的阴影6个星期之一 来自神经外科和物理医学与康复部门的临床导师， 参加每周一次的大查房，以了解TBI和SCI的临床性质， 他们的研究是有重点的。这将提高他们作为独立调查人员的能力， 在实验性神经创伤和中风损伤模型中的治疗发现， 了解如何以更容易实现的方式设计基础研究， 将有前景的治疗方法转化为临床研究和治疗试验。

PROJECT SUMMARY/ABSTRACT This is a renewal application requesting continued funding for a Neurobiology of CNS Injury and Repair T32 Training Program to support 4 predoctoral fellows working toward their Ph.D. degrees. During the first 4 years of the original funding period, 11 trainees have been appointed to the 2 year program, of which 5 have completed training and their Ph.D.s (3 in Physiology and 2 in Anatomy & Neurobiology). Of those 5, 2 are currently postdoctoral fellows, 2 have been hired into university faculty positions and 1 has moved on to medical school. Of the other 6 trainees, 2 are expected to finish their Ph.D.s during year 5 of the initial funding period. The remaining 4 are anticipated to complete their doctorates within the next two to three years. The training of the predoctoral fellows will be mainly carried out by training faculty whose primary appointments are either within the University of Kentucky (UK) Spinal Cord & Brain Injury Research Center (SCoBIRC) or are the affiliated with it as SCoBIRC Faculty Associates. Three of the SCoBIRC faculty associates have their primary appointments within the UK Sanders-Brown Center on Aging (SBCoA). In addition to their primary appointments, the SCoBIRC and/or SBCoA training faculty have their academic appointments in one of three UK College of Medicine basic science departments: Anatomy & Neurobiology, Physiology, or Molecular & Cellular Biochemistry. One additional training faculty is from the UK College of Pharmacy Department of Pharmaceutical Sciences. The overall goal of the proposed program will continue to be providing broad-based training in modern research concepts regarding the acute, subacute and chronic pathophysiology of SCI, TBI and stroke, and the identification of potential disease-modifying molecular targets that can drive the discovery of pharmacological or gene therapeutic strategies by which the devastating effects of these injuries can be ameliorated. These strategies will include both “neuroprotective” and “neurorestorative” approaches. Although it is anticipated that most of the trainees will pursue careers in laboratory-based therapeutic discovery research, they will also receive training in clinical aspects of the targeted neurological disorders and the practical issues involved in the design and conduct of neurological clinical trials. To accomplish this, the predoctoral fellows will spend one day/week for a semester shadowing one of 6 Clinical Tutors from the Departments Neurosurgery and Physical Medicine & Rehabilitation, and will attend weekly grand rounds to gain an understanding of the clinical nature of TBI and SCI upon which their research is focused. This will enhance their ability as independent investigators to not only make therapeutic discoveries in experimental neurotrauma and stroke injury models, but also provide them with knowledge concerning how to design their basic research in a manner that will more readily enable the translation of promising therapeutic approaches into clinical studies and therapeutic trials.