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EFFICACY OF BITTER TASTE BLOCKERS ON FLAVOR ACCEPTANCE IN PEDIATRIC POPULATIONS

苦味阻滞剂对儿童口味接受的功效

基本信息

批准号：
8210818
负责人：
JULIA ANNE MENNELLA
金额：
$ 31.39万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8210818
关键词：
8 year old Address Adenosine Monophosphate Adult Affect Age Biological Assay Biology Butyric Acids Caffeine Child Childhood Clinical Medicine Clinical Research Cognitive Complex Data Databases Deglutition Development Dose Drug Formulations Effectiveness Employee Strikes Encapsulated Family Flavoring Future Genes Genetic Variation Genotype Glutamates Health Human Individual Investigation Knowledge Label Lead Life Liquid substance Literature Mediator of activation protein Medicine Methods Modeling Oral Participant Pathway interactions Patients Pharmaceutical Preparations Pharmacologic Substance Play Population Procedures Propylthiouracil Psychophysiology Publishing Quinine Receptor Cell Relative (related person)Research Research Project Grants Role Scientific Advances and Accomplishments Sensory Signal Transduction Sodium Sodium gluconate Solid Staging Stimulus Sucrose Tablets Taste Perception Testing Urea Variant denatonium benzoate design dosage experience hedonic innovation insight novel pill preference programs public health priorities public health relevance receptor research study response sensory system

项目摘要

DESCRIPTION (provided by applicant): Taste plays a central role in clinical medicine and is crucial for pediatric patients because the unpleasant taste of drugs thwarts the benefits of even the most powerful drug. For two reasons, pediatric medications are particularly problematic. First, children often cannot or will not swallow pills or tablets (which encapsulates the inherently bitter tasting medications). Second, their enhanced (relative to adults) sensitivity to bitterness leads them to strongly reject bitter liquid medicines. We propose experimental studies applying recent scientific advances in bitter taste biology which have identified compounds that may interfere with bitter perception by taste receptor cells, to determine: (1) the effectiveness of these bitter blockers in children and adults for different model bitter compounds and (2) how age and genetic variation affects the efficacy of the bitter blockers. PUBLIC HEALTH RELEVANCE: Completion of this research project will lead to a better understanding of the how to ameliorate bitter tastes. It addresses a public health priority by 1) supporting efforts aimed at formulating better tasting pediatric medications, thus helping children avoid the serious health consequences from refusing to take medications; and 2) providing a framework and database using appropriate psychophysical testing procedures, model bitter compounds and currently identified bitter blockers, which will facilitate future clinical studies in which specific drugs can be compared and novel bitter blockers can be evaluated.

描述（由申请人提供）：味觉在临床医学中起着核心作用，对儿科患者至关重要，因为药物的难闻味道会阻碍即使是最强大的药物的益处。出于两个原因，儿科药物特别成问题。首先，儿童通常不能或不愿吞咽药丸或片剂（其中包含固有的苦味药物）。第二，他们对苦味的敏感性增强（相对于成年人），导致他们强烈拒绝苦味的液体药物。我们提出了应用苦味生物学的最新科学进展的实验研究，这些研究已经确定了可能干扰味觉受体细胞的苦味感知的化合物，以确定：（1）这些苦味阻滞剂在儿童和成人中对不同模型苦味化合物的有效性，以及（2）年龄和遗传变异如何影响苦味阻滞剂的功效。公共卫生相关性：完成这项研究项目将有助于更好地了解如何改善苦味。它通过以下方式解决公共卫生优先事项：1）支持旨在制定更好的儿科药物的努力，从而帮助儿童避免因拒绝服药而造成的严重健康后果;和2）使用适当的心理物理学测试程序、模型苦味化合物和目前鉴定的苦味阻断剂提供框架和数据库，这将促进未来的临床研究，其中可以比较特定的药物并可以评价新的苦味阻断剂。