Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
基本信息
- 批准号:8482440
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-01 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAddressAffectAmphetamine AbuseAmphetaminesAmygdaloid structureAnimal ModelAnxietyAreaAttenuatedBehaviorBehavioralBody RegionsBrainBrain regionCell NucleusChronicComplementCorticosteroneCorticotropin-Releasing HormoneDetectionDevelopmentDiseaseDrug AddictionDrug abuseEndocrineExcisionFrightFunctional disorderGlucocorticoid ReceptorGoalsHippocampus (Brain)HourHumanIllicit DrugsInfusion proceduresLong-Term EffectsMarijuana AbuseMeasuresMedialMediatingMental DepressionMethamphetamineModelingNeurobiologyNeurologicNeuropeptidesOrganic Cation TransporterPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPrefrontal CortexProthrombinRattusRelapseResearchSerotoninSignal TransductionStressSubstance Withdrawal SyndromeSystemTestingTimeTissuesUp-RegulationWithdrawalWithdrawal SymptomWorld Health Organizationaddictiondorsal raphe nucleusdrug abstinencedrug cravingdrug relapsedrug withdrawalextracellularneuroadaptationneuromechanismneuronal cell bodyneurotransmissionnovelpreventprotein functionpsychologicpsychostimulantreceptorreceptor expressionrelating to nervous systemresearch studyresponseserotonin transporterstressortherapy designtransmission processurocortin II
项目摘要
DESCRIPTION (provided by applicant): The World Health Organization identifies methamphetamine as the second most widely abused illicit drug after marijuana, and abuse of prescription amphetamines in the US is increasing. Drug addiction is a chronic and relapsing disorder, and relapse is thought to arise, in part, from the need to alleviate negative withdrawal symptoms such as anxiety and depression. Amphetamine abuse is associated with a withdrawal syndrome that includes increased anxiety states during drug abstinence. We have developed a rat model of heightened anxiety during amphetamine withdrawal and have identified changes in serotonergic neurotransmission within several key limbic brain areas that are important for fear, anxiety and stress states. The goal of the current proposal is to elucidate the mechanisms by which amphetamine withdrawal results in altered serotonergic neurotransmission, and directly relate these to heightened anxiety states and stress sensitivity during withdrawal. Furthermore this proposal will test traditional and novel pharmacotherapies in this rat model of amphetamine withdrawal, to determine whether normalizing serotonergic function in the brain reverses heightened anxiety states that are observed during abstinence from amphetamine.
描述(由申请人提供):世界卫生组织将甲基苯丙胺确定为大麻之后第二大滥用非法药物,美国处方安非他明的滥用正在增加。药物成瘾是一种慢性和复发性疾病,复发被认为部分是由于需要减轻消极的戒断症状,如焦虑和抑郁。安非他明滥用与戒断综合征有关,戒断综合征包括戒毒期间焦虑状态增加。我们已经开发了一种大鼠模型,在苯丙胺戒断过程中焦虑加剧,并确定了几个关键的边缘脑区域内的多巴胺能神经传递的变化,这些区域对恐惧,焦虑和压力状态很重要。目前的建议的目标是阐明安非他明戒断导致改变的多巴胺能神经传递的机制,并直接将这些与戒断过程中的焦虑状态和应激敏感性升高联系起来。此外,该提案将在安非他明戒断的大鼠模型中测试传统和新型药物疗法,以确定大脑中的多巴胺能功能正常化是否逆转在安非他明戒断期间观察到的高度焦虑状态。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gina L Forster其他文献
Gina L Forster的其他文献
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{{ truncateString('Gina L Forster', 18)}}的其他基金
NEURAL MECHANISMS UNDERLYING ADAPTIVE COPING SOCIALLY INDUCED ANXIETY
适应性应对社会引起的焦虑的神经机制
- 批准号:
7959608 - 财政年份:2009
- 资助金额:
$ 1.34万 - 项目类别:
NEURAL MECHANISMS UNDERLYING ADAPTIVE COPING SOCIALLY INDUCED ANXIETY
适应性应对社会引起的焦虑的神经机制
- 批准号:
7720352 - 财政年份:2008
- 资助金额:
$ 1.34万 - 项目类别:
NEURAL MECHANISMS UNDERLYING ADAPTIVE COPING SOCIALLY INDUCED ANXIETY
适应性应对社会引起的焦虑的神经机制
- 批准号:
7627578 - 财政年份:2007
- 资助金额:
$ 1.34万 - 项目类别:
NEURAL MECHANISMS UNDERLYING ADAPTIVE COPING SOCIALLY INDUCED ANXIETY
适应性应对社会引起的焦虑的神经机制
- 批准号:
7381105 - 财政年份:2006
- 资助金额:
$ 1.34万 - 项目类别:
Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
- 批准号:
8289490 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
- 批准号:
7242503 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
- 批准号:
8464039 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
- 批准号:
7080493 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
Neural Sensitivity to Stress During Drug Withdrawal
停药期间神经对压力的敏感性
- 批准号:
8183906 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
USD MED: AMYGDALA-CORTICAL CIRCUITRY--STRESS RESPONSE
USD MED:杏仁核-皮质环路--应激反应
- 批准号:
7170271 - 财政年份:2005
- 资助金额:
$ 1.34万 - 项目类别:
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