Sexual Networks, Drugs, and HIV Risk among Men Who Have Sex With Men

男男性行为者的性网络、毒品和艾滋病毒风险

• 批准号: 8212052
• 负责人: Hong Van Nhu Tieu
• 金额: $ 17.57万
• 依托单位: NEW YORK BLOOD CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212052
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Anus; Applications Grants; Behavioral; Biometry; Blood; Characteristics; Cities; Clinical Research; Collection; Commit; Communities; Crack Cocaine; Data; Data Collection; Development; Drug usage; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Ethnic Origin; Faculty; Funding; Goals; HIV; HIV Infections; Health; Hispanics; Individual; Intervention; Investigation; Lead; Left; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Neighborhoods; Network-based; New York; New York City; Outcome; Participant; Pathway Analysis; Persons; Pharmaceutical Preparations; Population; Prevalence; Prevention; Prevention Research; Qualitative Methods; Qualitative Research; Race; Recording of previous events; Records; Research; Research Methodology; Research Personnel; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Sexual Partners; Social Network; Structure; Testing; Training; United States; United States National Institutes of Health; beryl; cocaine use; contextual factors; density; design; experience; innovation; men; men who have sex with men; multidisciplinary; programs; public health relevance; sex; sex risk; skills; social; success; transmission process

DESCRIPTION (provided by applicant): This K01 award will provide Dr. Hong Van Tieu with the necessary training and mentorship to become an independent investigator in HIV epidemiology and prevention. Her short-term goals are to expand her experience in HIV epidemiology and prevention research among men who have sex with men (MSM), gain advanced skills in epidemiology, biostatistics, social network analysis, and qualitative research, and further the understanding of the influence of sexual networks on HIV and sexual risk behaviors among Black and White MSM. She will receive specialized training in the epidemiology of substance use and its relationship to HIV risk among MSM. Her multidisciplinary mentoring team has expertise in HIV and substance use epidemiology, prevention, and clinical research and strong track records of supporting junior faculty to become independently funded investigators. The New York Blood Center has a long history of conducting HIV epidemiology and behavioral and biomedical prevention research among MSM and is profoundly committed to the success of this K01 award. The dramatically disproportionate HIV infection rates among Black MSM in the U.S remain unexplained by differences in individual behavioral risk. One hypothesis is that the characteristics of sexual networks of Black MSM place them at increased risk of HIV compared to non-Black MSM. The purpose of this study is to directly compare the structural and compositional characteristics of sexual networks between Black and White MSM and to examine the relationship of their network characteristics to HIV infection and sexual risk behaviors using an innovative combination of qualitative and quantitative research methodologies. The proposed research will enroll a large sample of Black and White MSM (n=878) in New York City as a substudy of an NIH R01-funded study to evaluate the hypothesis that certain structural (e.g., network size, density, partner concurrency) and compositional (e.g., assortative and disassortative mixing, durability of relationships) characteristics of Black MSM sexual networks increase the men's risk of HIV infection. The specific aims of this study are the following: (1) to describe and compare the structural and compositional characteristics of sexual networks between Black and White MSM at the egocentric network level, (2) to compare the association of structural and compositional characteristics of sexual networks with HIV infection and sexual risk behaviors between Black and White MSM at the egocentric network level, and determine whether differences in sexual network characteristics explain the disparity in HIV prevalence between Black and White MSM, and (3) to explore in depth the contexts and meanings of sexual partnerships and networks by evaluating how Black and White MSM subjectively experience their sexual networks and perceive them to influence their sexual risk behaviors using qualitative research methods. A focus of the research is on drug and alcohol use within sexual networks and their relationship to HIV risk among MSM. This research will provide critically important information on the sexual networks of Black MSM to explain the alarming rates of HIV infection among this population and to inform development and testing of sexual network-based intervention strategies to reduce HIV acquisition and transmission risk. It will also serve as an excellent platform for the candidate to gain essential training in HIV epidemiology and prevention research and generate innovative ideas for her first R01 grant application. PUBLIC HEALTH RELEVANCE: The purpose of this study is to examine and compare the structure and make-up of sexual networks (connections between sexual partners) among Black and White men who have sex with men in New York City and assess the relationship of these characteristics to HIV infection and sexual risk behaviors. This study will have direct impact on the design of programs to reduce HIV infection rates among men who have sex with men.

描述（由申请人提供）：这个K01奖将提供博士洪货车Tieu与必要的培训和指导，成为一个独立的调查人员在艾滋病毒流行病学和预防。她的短期目标是扩大她的经验，在艾滋病毒流行病学和预防研究中的男性与男性发生性关系（MSM），获得先进的流行病学，生物统计学，社会网络分析和定性研究的技能，并进一步了解性网络对艾滋病毒和性风险行为的影响在黑人和白色男男性接触者。她将接受药物使用流行病学及其与男男性行为者艾滋病毒风险关系方面的专门培训。她的多学科指导团队在艾滋病毒和药物使用流行病学，预防和临床研究方面具有专业知识，并支持初级教师成为独立资助的研究人员。纽约血液中心在MSM人群中开展艾滋病流行病学、行为学和生物医学预防研究方面有着悠久的历史，并致力于K01奖的成功。美国黑人男男性行为者中艾滋病毒感染率的显著不成比例仍然无法用个体行为风险的差异来解释。一种假设是，与非黑人男男性接触者相比，黑人男男性接触者的性网络特征使他们感染艾滋病毒的风险增加。本研究的目的是直接比较黑人和白色男男性接触者性网络的结构和组成特征，并采用定性和定量相结合的研究方法，探讨他们的网络特征与艾滋病感染和性风险行为的关系。拟议的研究将在纽约市招募大量黑人和白色MSM样本（n=878），作为NIH R01资助研究的子研究，以评估某些结构（例如，网络大小、密度、伙伴并发性）和组成（例如，黑人男男性接触者性网络的特点增加了男性感染艾滋病毒的风险。这项研究的具体目标如下：（1）在自我中心网络水平上描述和比较黑人和白色MSM性网络的结构和组成特征。（2）在自我中心网络水平上比较黑人和白色MSM性网络的结构和组成特征与HIV感染和性风险行为的关联。并确定性网络特征的差异是否解释了黑人和白色MSM之间艾滋病毒流行率的差异，以及（3）通过评估黑人和白色MSM如何主观体验他们的性网络，并感知他们如何影响他们的性风险行为，深入探索性伙伴关系和网络的背景和意义。质的研究方法。研究的重点是性网络中的毒品和酒精使用及其与男男性行为者艾滋病毒风险的关系。这项研究将提供关于黑人男男性行为者性网络的重要信息，以解释这一人群中艾滋病毒感染率惊人的原因，并为基于性网络的干预策略的开发和测试提供信息，以减少艾滋病毒的获得和传播风险。它也将作为一个很好的平台，为候选人获得艾滋病毒流行病学和预防研究的基本培训，并为她的第一个R01赠款申请产生创新的想法。 公共卫生相关性：本研究的目的是检查和比较的结构和组成的性网络（性伙伴之间的连接）之间的黑人和白色男子与男性发生性关系的男性在纽约市和评估这些特征的关系，艾滋病毒感染和性风险行为。这项研究将对降低男男性行为者艾滋病毒感染率的方案设计产生直接影响。