Sexual Networks, Drugs, and HIV Risk among Men Who Have Sex With Men

男男性行为者的性网络、毒品和艾滋病毒风险

• 批准号: 8410572
• 负责人: Hong Van Nhu Tieu
• 金额: $ 17.57万
• 依托单位: NEW YORK BLOOD CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8410572
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Anus; Applications Grants; Behavioral; Biometry; Blood; Characteristics; Cities; Clinical Research; Collection; Commit; Communities; Crack Cocaine; Data; Data Collection; Development; Drug usage; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Ethnic Origin; Faculty; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Hispanics; Individual; Intervention; Investigation; Lead; Left; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Neighborhoods; Network-based; New York; New York City; Outcome; Participant; Pathway Analysis; Persons; Pharmaceutical Preparations; Population; Prevalence; Prevention; Prevention Research; Qualitative Methods; Qualitative Research; Race; Recording of previous events; Records; Research; Research Methodology; Research Personnel; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Sexual Partners; Social Network; Structure; Testing; Training; United States; United States National Institutes of Health; beryl; cocaine use; contextual factors; density; design; experience; innovation; men; men who have sex with men; multidisciplinary; programs; public health relevance; sex; sex risk; skills; social; success; transmission process

DESCRIPTION (provided by applicant): This K01 award will provide Dr. Hong Van Tieu with the necessary training and mentorship to become an independent investigator in HIV epidemiology and prevention. Her short-term goals are to expand her experience in HIV epidemiology and prevention research among men who have sex with men (MSM), gain advanced skills in epidemiology, biostatistics, social network analysis, and qualitative research, and further the understanding of the influence of sexual networks on HIV and sexual risk behaviors among Black and White MSM. She will receive specialized training in the epidemiology of substance use and its relationship to HIV risk among MSM. Her multidisciplinary mentoring team has expertise in HIV and substance use epidemiology, prevention, and clinical research and strong track records of supporting junior faculty to become independently funded investigators. The New York Blood Center has a long history of conducting HIV epidemiology and behavioral and biomedical prevention research among MSM and is profoundly committed to the success of this K01 award. The dramatically disproportionate HIV infection rates among Black MSM in the U.S remain unexplained by differences in individual behavioral risk. One hypothesis is that the characteristics of sexual networks of Black MSM place them at increased risk of HIV compared to non-Black MSM. The purpose of this study is to directly compare the structural and compositional characteristics of sexual networks between Black and White MSM and to examine the relationship of their network characteristics to HIV infection and sexual risk behaviors using an innovative combination of qualitative and quantitative research methodologies. The proposed research will enroll a large sample of Black and White MSM (n=878) in New York City as a substudy of an NIH R01-funded study to evaluate the hypothesis that certain structural (e.g., network size, density, partner concurrency) and compositional (e.g., assortative and disassortative mixing, durability of relationships) characteristics of Black MSM sexual networks increase the men's risk of HIV infection. The specific aims of this study are the following: (1) to describe and compare the structural and compositional characteristics of sexual networks between Black and White MSM at the egocentric network level, (2) to compare the association of structural and compositional characteristics of sexual networks with HIV infection and sexual risk behaviors between Black and White MSM at the egocentric network level, and determine whether differences in sexual network characteristics explain the disparity in HIV prevalence between Black and White MSM, and (3) to explore in depth the contexts and meanings of sexual partnerships and networks by evaluating how Black and White MSM subjectively experience their sexual networks and perceive them to influence their sexual risk behaviors using qualitative research methods. A focus of the research is on drug and alcohol use within sexual networks and their relationship to HIV risk among MSM. This research will provide critically important information on the sexual networks of Black MSM to explain the alarming rates of HIV infection among this population and to inform development and testing of sexual network-based intervention strategies to reduce HIV acquisition and transmission risk. It will also serve as an excellent platform for the candidate to gain essential training in HIV epidemiology and prevention research and generate innovative ideas for her first R01 grant application.

描述（由申请人提供）：该K01奖将为Hong Van Tieu博士提供必要的培训和指导，以成为HIV流行病学和预防的独立研究者。她的短期目标是在与男性发生性关系的男性中扩大她在艾滋病毒流行病学和预防研究方面的经验，在流行病学，生物统计学，社交网络分析和定性研究方面获得高级技能，并进一步了解性网络对艾滋病毒和黑人白人邮件中的性别网络对艾滋病毒和性风险行为的影响。她将接受有关药物使用流行病学的专门培训及其与MSM中艾滋病毒风险的关系。她的多学科指导团队在艾滋病毒和使用物质的流行病学，预防和临床研究以及支持初级教师成为独立资助的研究人员方面具有专业知识。纽约血液中心在MSM中进行了较长的历史，即进行HIV流行病学以及行为和生物医学预防研究，并深深致力于该K01奖的成功。美国黑人MSM中的艾滋病毒感染率极不成比例，无法通过个人行为风险差异来解释。一个假设是，与非黑色MSM相比，黑色MSM性网络的特征使他们面临HIV的风险增加。这项研究的目的是直接比较黑人和白色MSM之间性网络的结构和组成特征，并使用定性和定量研究方法的创新组合检查其网络特征与HIV感染和性风险行为的关系。拟议的研究将在纽约市注册大量的黑白MSM（n = 878）样本，作为NIH R01资助的研究的一种方法，以评估某些结构性（例如网络大小，密度，密度，伴侣并发）和组成的假设（例如，财产和拆卸性混合，关系的耐用性）heriv heriv heriv a smsm smm smm a versy的特征是herv hers thems smm s neversy of黑人的特征。这项研究的具体目的如下：（1）描述和比较在eG中心网络上黑人和白色MSM之间性网络的结构和组成特征（2），以比较性网络与HIV感染与网络中的黑人和白色MSM之间的性风险行为之间的结构和组成特征的关联，以及在EGoccentric中的特征之间的差异，是否在EGoccentric中的特征差异黑白MSM和（3）通过评估黑人和白色MSM如何主观体验他们的性网络并感知他们使用定性研究方法来影响他们的性风险行为，以深入探索性伙伴关系和网络的背景和含义。该研究的重点是性网络中的药物和饮酒及其与MSM中的艾滋病毒风险的关系。这项研究将提供有关黑色MSM性网络的至关重要的重要信息，以解释该人群中艾滋病毒感染的惊人率，并为基于性网络的干预策略的开发和测试提供信息，以减少艾滋病毒的获取和传播风险。它还将成为候选人获得艾滋病毒流行病学和预防研究基本培训的绝佳平台，并为她的第一个R01赠款应用程序创新思想。