Sexual Networks, Drugs, and HIV Risk among Men Who Have Sex With Men

男男性行为者的性网络、毒品和艾滋病毒风险

• 批准号: 8410572
• 负责人: Hong Van Nhu Tieu
• 金额: $ 17.57万
• 依托单位: NEW YORK BLOOD CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-15 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8410572
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Anus; Applications Grants; Behavioral; Biometry; Blood; Characteristics; Cities; Clinical Research; Collection; Commit; Communities; Crack Cocaine; Data; Data Collection; Development; Drug usage; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Ethnic Origin; Faculty; Funding; Goals; HIV; HIV Infections; HIV risk; Health; Hispanics; Individual; Intervention; Investigation; Lead; Left; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Neighborhoods; Network-based; New York; New York City; Outcome; Participant; Pathway Analysis; Persons; Pharmaceutical Preparations; Population; Prevalence; Prevention; Prevention Research; Qualitative Methods; Qualitative Research; Race; Recording of previous events; Records; Research; Research Methodology; Research Personnel; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Sexual Partners; Social Network; Structure; Testing; Training; United States; United States National Institutes of Health; beryl; cocaine use; contextual factors; density; design; experience; innovation; men; men who have sex with men; multidisciplinary; programs; public health relevance; sex; sex risk; skills; social; success; transmission process

DESCRIPTION (provided by applicant): This K01 award will provide Dr. Hong Van Tieu with the necessary training and mentorship to become an independent investigator in HIV epidemiology and prevention. Her short-term goals are to expand her experience in HIV epidemiology and prevention research among men who have sex with men (MSM), gain advanced skills in epidemiology, biostatistics, social network analysis, and qualitative research, and further the understanding of the influence of sexual networks on HIV and sexual risk behaviors among Black and White MSM. She will receive specialized training in the epidemiology of substance use and its relationship to HIV risk among MSM. Her multidisciplinary mentoring team has expertise in HIV and substance use epidemiology, prevention, and clinical research and strong track records of supporting junior faculty to become independently funded investigators. The New York Blood Center has a long history of conducting HIV epidemiology and behavioral and biomedical prevention research among MSM and is profoundly committed to the success of this K01 award. The dramatically disproportionate HIV infection rates among Black MSM in the U.S remain unexplained by differences in individual behavioral risk. One hypothesis is that the characteristics of sexual networks of Black MSM place them at increased risk of HIV compared to non-Black MSM. The purpose of this study is to directly compare the structural and compositional characteristics of sexual networks between Black and White MSM and to examine the relationship of their network characteristics to HIV infection and sexual risk behaviors using an innovative combination of qualitative and quantitative research methodologies. The proposed research will enroll a large sample of Black and White MSM (n=878) in New York City as a substudy of an NIH R01-funded study to evaluate the hypothesis that certain structural (e.g., network size, density, partner concurrency) and compositional (e.g., assortative and disassortative mixing, durability of relationships) characteristics of Black MSM sexual networks increase the men's risk of HIV infection. The specific aims of this study are the following: (1) to describe and compare the structural and compositional characteristics of sexual networks between Black and White MSM at the egocentric network level, (2) to compare the association of structural and compositional characteristics of sexual networks with HIV infection and sexual risk behaviors between Black and White MSM at the egocentric network level, and determine whether differences in sexual network characteristics explain the disparity in HIV prevalence between Black and White MSM, and (3) to explore in depth the contexts and meanings of sexual partnerships and networks by evaluating how Black and White MSM subjectively experience their sexual networks and perceive them to influence their sexual risk behaviors using qualitative research methods. A focus of the research is on drug and alcohol use within sexual networks and their relationship to HIV risk among MSM. This research will provide critically important information on the sexual networks of Black MSM to explain the alarming rates of HIV infection among this population and to inform development and testing of sexual network-based intervention strategies to reduce HIV acquisition and transmission risk. It will also serve as an excellent platform for the candidate to gain essential training in HIV epidemiology and prevention research and generate innovative ideas for her first R01 grant application.

描述（由申请人提供）：该 K01 奖项将为 Hong Van Tieu 博士提供必要的培训和指导，使其成为艾滋病毒流行病学和预防领域的独立研究者。她的短期目标是扩大她在男男性行为者 (MSM) 的艾滋病毒流行病学和预防研究方面的经验，获得流行病学、生物统计学、社交网络分析和定性研究方面的高级技能，并进一步了解性网络对黑人和白人 MSM 中艾滋病毒和性危险行为的影响。她将接受关于物质使用流行病学及其与 MSM 中艾滋病毒风险关系的专门培训。她的多学科指导团队拥有艾滋病毒和药物滥用流行病学、预防和临床研究方面的专业知识，并在支持初级教师成为独立资助的研究人员方面拥有良好的记录。纽约血液中心在 MSM 中开展 HIV 流行病学以及行为和生物医学预防研究方面有着悠久的历史，并坚定地致力于 K01 奖项的成功。美国黑人男男性接触者中艾滋病毒感染率极不成比例的现象仍然无法用个体行为风险的差异来解释。一种假设是，与非黑人男男性接触者相比，黑人男男性接触者的性网络特征使他们感染艾滋病毒的风险更高。本研究的目的是直接比较黑人和白人 MSM 之间性网络的结构和组成特征，并利用定性和定量研究方法的创新组合来研究其网络特征与 HIV 感染和性危险行为的关系。拟议的研究将在纽约市招募大量黑人和白人 MSM 样本（n = 878），作为 NIH R01 资助的一项研究的子研究，以评估黑人 MSM 性网络的某些结构（例如网络规模、密度、伴侣并发性）和组成（例如选型和不选型混合、关系的持久性）特征会增加男性感染 HIV 的风险这一假设。本研究的具体目的如下：（1）在自我中心网络水平上描述和比较黑人和白人 MSM 之间性网络的结构和组成特征，（2）在自我中心网络水平上比较黑人和白人 MSM 之间性网络的结构和组成特征与 HIV 感染和性危险行为的关联，并确定性网络特征的差异是否解释了黑人和白人 MSM 之间 HIV 感染率的差异。 黑人和白人 MSM，以及 (3) 通过使用定性研究方法评估黑人和白人 MSM 如何主观体验其性网络并感知它们如何影响其性风险行为，深入探索性伙伴关系和网络的背景和意义。该研究的重点是性网络中吸毒和酗酒及其与 MSM 中艾滋病毒风险的关系。这项研究将提供有关黑人男同性恋者性网络的极其重要的信息，以解释该人群中令人震惊的艾滋病毒感染率，并为制定和测试基于性网络的干预策略提供信息，以减少艾滋病毒感染和传播风险。它还将为候选人提供一个绝佳的平台，让他们获得艾滋病毒流行病学和预防研究方面的基本培训，并为她的第一个 R01 拨款申请产生创新想法。